Protein Alignment ABL2 and lsb1

DIOPT Version :10

• Sequence 1: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Sequence 2: NP_595286.1
• Gene: lsb1 / 2539945
• PomBaseID: SPBC119.05C
• Length: 296
• Species: Schizosaccharomyces pombe
• Alignment Length: 298
• Identity: 62/298 - (20%)
• Similarity: 87/298 - (29%)
• Gaps: 110/298 - (36%)

Human   765 AGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRA 829
            |.:|..| ....|.|:..|:....:|.......||:|.:|...     :||      |||
pombe    53 AAQPVES-SVPLPLPKRKSSVEKRAGSVASAVAAMSLSQNSGE-----KRT------PEE----- 100

Human   830 NDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKN 894
                |:|.....||.::...:.:                .:.|||.||.....|    |....||
pombe   101 ----PRKLPGVPAPQKQSEASSV----------------NSSTEKLPPPPSYPG----PNTAHKN 141

Human   895 GGARLGMAGVP-EDGEQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPAD---VQLIGTDS-- 953
            ....|.|...| .|....|:               |...|:|  .|:|...|   .:|.|.:.
pombe   142 VERVLAMYDFPGPDAGDLGF---------------HAGEVII--VLEHVNNDWWRGELNGKEGIF 189

Human   954 QGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEE-PTALTAGQSTSE 1017
            ..|..:||.:..|              |..|||||             |.:. |.|.::.....:
pombe   190 PSNYVRLLEDSAV--------------KAQPPPPP-------------PQQNYPPAASSSAPPMQ 227

Human  1018 TQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTSSISP 1055
            .|:                  ...||.|.|.|.....|
pombe   228 YQQ------------------TAYPPQQAPYPPVQAYP 247

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784
		SH2_ABL	169..262	CDD:198189
		PTKc_Abl	281..543	CDD:270645
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930		34/165 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794		7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851		9/43 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024		11/60 (18%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		6/36 (17%)
		FABD	1063..1182	CDD:197885
lsb1	NP_595286.1	SH3	142..195	CDD:214620	14/69 (20%)