DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABL2 and abl-1

DIOPT Version :10

Sequence 1:NP_009298.1 Gene:ABL2 / 27 HGNCID:77 Length:1182 Species:Homo sapiens
Sequence 2:NP_509778.2 Gene:abl-1 / 181261 WormBaseID:WBGene00000018 Length:1224 Species:Caenorhabditis elegans


Alignment Length:1377 Identity:432/1377 - (31%)
Similarity:614/1377 - (44%) Gaps:380/1377 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    10 EAPGLQQP--QPRGIRGSSAARPSGRRRDP-----AGRTTET------GFNIFTQHDHFASCVED 61
            |.|...||  .|:....|..|....|.:.|     :.||.::      .|:.|...:..:|... 
 Worm    20 EDPVFDQPVASPKSEISSKLAEEIERSKSPLILEVSPRTPDSVQMFRPTFDTFRPPNSDSSTFR- 83

Human    62 GFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTL 126
                   |..|.|.|       |...::|..........:..::.|...||||||||...|:..|
 Worm    84 -------GSQSREDL-------VACSSMNSVNNVHDMNTVSSSSSSSAPLFVALYDFHGVGEEQL 134

Human   127 SITKGEKLRVLGYNQNGEWSEVR----SKN--------GQ-GWVPSNYITPVNSLEKHSWYHGPV 178
            |:.||:::|:||||:|.||.|.|    .||        |: ||||||:|.|.|||:|::||||.:
 Worm   135 SLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKI 199

Human   179 SRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAE 243
            |||.:|.:|.|.|.|||||||||:|.||.:||:|::|||:|||||.....|:::|.|.:|.||.|
 Worm   200 SRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGE 264

Human   244 LVHHHSTVADGLVTTLHYPAPKCNKPT-VYGVSP-IHDKWEMERTDITMKHKLGGGQYGEVYVGV 306
            ||||||..||||:..|.|||.|.:|.. ::.:|| ..|:||::|::|.|.:||||||||:||.|.
 Worm   265 LVHHHSVHADGLICLLMYPASKKDKGRGLFSLSPNAPDEWELDRSEIIMHNKLGGGQYGDVYEGY 329

Human   307 WKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLD 371
            ||::..|:|||.||||.|.:.|||.|||:||::.|.|||:||||||.|.||||:||:|..||||:
 Worm   330 WKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLE 394

Human   372 YLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 436
            |||..::..:..::|:.||:||:|.|.|||.::|||||||||||||.|:::||:|||||:|.|..
 Worm   395 YLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKIADFGLARFMKE 459

Human   437 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKG 501
            |||||||||||||||||||.||:||||.|||||||||||||||||||:||||::||.||.|||.|
 Worm   460 DTYTAHAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENG 524

Human   502 YRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVV 566
            :||:.|:||||.||.||..||.|||:|||.|.:.|...|.:...:|:::||.::|.:.....   
 Worm   525 FRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLISSNSLNDEVQKQLKKNNDKK--- 586

Human   567 PYLPRLPILPSKTR--TLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALPRKQRD 629
                    |.|..|  .::::.::|.......|...:..|         ..:.:.:|.:|.:...
 Worm   587 --------LESDKRRSNVRERSDSKSRHSSHHDRDRDRES---------LHSRNSNPEIPNRSFI 634

Human   630 KSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVAS 694
            ::..|:               .||:        |:...:.:|||                     
 Worm   635 RTDDSV---------------SFFN--------PSTTSKVTSFR--------------------- 655

Human   695 LQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSGITGFFTPRLIKK 759
               |.|..|.|        ||        |:|.                         .|:|:|.
 Worm   656 ---AQGPPFPP--------PP--------QQNT-------------------------KPKLLKS 676

Human   760 TLGLRAGKPTASDDTSK-------PFPRSNSTSSMSSGLPEQDRMAMTLPRNCQR---------- 807
            .|...|..  ||::..:       |....|...:::       |:..|:|:. ||          
 Worm   677 VLNSNARH--ASEEFERNEQDDVVPLAEKNVRKAVT-------RLGGTMPKG-QRIDAYLDSMRR 731

Human   808 ---------------SKLQLERTVSTSSQPEENVDRANDMLP-KKSEESAAPSRERP-------- 848
                           ....|.||||..|.         |.|| ..|..|:...:..|        
 Worm   732 VDSWKESTDADNEGAGSSSLSRTVSNDSL---------DTLPLPDSMNSSTYVKMHPASGENVFL 787

Human   849 ---KAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQ 910
               ::||..|..|.......|.....|.|.         ..:|.|.......:..:...||..|.
 Worm   788 RQIRSKLKKRSETPELDHIDSDTADETTKS---------EKSPFGSLNKSSIKYPIKNAPEFSEN 843

Human   911 PGWPSPAKAAPVLPTTHNHKVPVLISPTLK------HTPADV-------------QLIGTDSQGN 956
            ....||   .||.|   :....|.:.|..|      .|..||             :::..||..|
 Worm   844 HSRVSP---VPVPP---SRNASVSVRPDSKAEDSSDETTKDVGMWGPKHAVTRKIEIVKNDSYPN 902

Human   957 -----KFKL-----LSEHQVTSSGDKDRP-----------------------RRVKPKCAPPPPP 988
                 |.|:     :.:.:..:|..:|.|                       :.|..|.:|    
 Worm   903 VEGELKAKIRNLRHVPKEESNTSSQEDLPLDATDNTNDSIIVIPRDEKAKVRQLVTQKVSP---- 963

Human   989 VMRLLQH--PSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQ------ 1045
                |||  |.....|.   .:.::..|.||..:..:.::|..|  ..:..:|.:|..:      
 Worm   964 ----LQHHRPFSLQCPN---NSTSSAISHSEHADSSETSSLSGV--YEERMKPELPRKRSNGDTK 1019

Human  1046 -VPLPTSSISPAKMANGTAGTK------------------------------------------- 1066
             ||: |..|:..|..||.|.||                                           
 Worm  1020 VVPV-TWIINGEKEPNGMARTKSLRDITSKFEQLGTASTIESKIEEAVPYREHALEKKGTSKRFS 1083

Human  1067 -----------VALRKTKQAAEKISADK--ISKEALLECA-----------DLLSSALTEPVPNS 1107
                       |..||.:...|..|.|:  :||:.::...           :|.||.:|:.....
 Worm  1084 MLEGSNELKHVVPPRKNRNQDESGSIDEEPVSKDMIVSLLKVIQKEFVNLFNLASSEITDEKLQQ 1148

Human  1108 QLV--DTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNNLL 1170
            .::  |...:|...||.|.:.| ...:||.|:|.:|:||:..::::.|..    |...||.:.|.
 Worm  1149 FVIMADNVQKLHSTCSVYAEQI-SPHSKFRFKELLSQLEIYNRQIKFSHN----PRAKPVDDKLK 1208

Human  1171 SCVQEISDVVQR 1182
            ...|:..|.:.|
 Worm  1209 MAFQDCFDQIMR 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABL2NP_009298.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47 11/49 (22%)
CAP 2..106 20/108 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..80 4/19 (21%)
SH3_Abl 111..164 CDD:212784 33/65 (51%)
SH2_ABL 169..262 CDD:198189 53/92 (58%)
PTKc_Abl 281..543 CDD:270645 171/261 (66%)
Kinase activation loop. /evidence=ECO:0000250 427..451 19/23 (83%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..641 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..674 3/19 (16%)
Nuclear localization signal. /evidence=ECO:0000255 658..660 0/1 (0%)
F-actin-binding. /evidence=ECO:0000250 694..930 51/279 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 763..794 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 807..851 13/80 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1024 14/84 (17%)
F-actin-binding. /evidence=ECO:0000250 1020..1182 46/237 (19%)
FABD 1063..1182 CDD:197885 35/187 (19%)
abl-1NP_509778.2 SH3_Abl 119..185 CDD:212784 33/65 (51%)
SH2_ABL 190..283 CDD:198189 53/92 (58%)
PTKc_Abl 304..566 CDD:270645 171/261 (66%)
FABD 1091..1224 CDD:197885 33/135 (24%)

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