Protein Alignment ABL2 and Abl2

DIOPT Version :10

• Sequence 1: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Sequence 2: NP_033725.2
• Gene: Abl2 / 11352
• MGIID: 87860
• Length: 1182
• Species: Mus musculus
• Alignment Length: 1184
• Identity: 1120/1184 - (94%)
• Similarity: 1136/1184 - (95%)
• Gaps: 4/1184 - (0%)

Human     1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEG 65
            |||||||||||||||||||||||||||||||||||||||||.:.|||:|||||||||||||||||
Mouse     1 MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTADAGFNVFTQHDHFASCVEDGFEG 65

Human    66 DKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITK 130
            |||||||||.||||:|||.|.||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 DKTGGSSPEVLHRPFGCDAESQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITK 130

Human   131 GEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 GEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSF 195

Human   196 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260
            ||||||||||||||||||||||||||||||.|.||||||||||||||||||||||||||||||||
Mouse   196 LVRESESSPGQLSISLRYEGRVYHYRINTTTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260

Human   261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTME 325

Human   326 VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMA 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Mouse   326 VEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMA 390

Human   391 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 455

Human   456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520

Human   521 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQ 585
            ||||||||||||||||||||||||||||||||||||||.||||||||||||||:||||||||:||
Mouse   521 CWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLRKQ 585

Human   586 VENKENIEGAQDATENSASSLAP-GFIRGAQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRK 649
            .|||||::|..||.|:.|||.|| ||||..|||||||||||||||||||||||||||||||||||
Mouse   586 GENKENLDGGLDAAESLASSSAPAGFIRSTQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDRK 650

Human   650 GGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSSVASLQHADGFSFTPAQQEANLVP 714
            |||||||||||||||||||||||||||||||||||||||||.|||||||||||..|:|||.||||
Mouse   651 GGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTGNFSPVASLQHADGFSVAPSQQEPNLVP 715

Human   715 PKCYGGSFAQRNLC-NDDGGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPF 778
            .||||||||||||| :||.||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 AKCYGGSFAQRNLCADDDSGGGGGSGTAGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPF 780

Human   779 PRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAP 843
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse   781 PRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEEGAAP 845

Human   844 SRERPKAKLLPRGATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDG 908
            :|||||||||||||||||||.|  |.||||.|.||||||||||||||||:|||.|||:|||||||
Mouse   846 ARERPKAKLLPRGATALPLRAP--DPAITESDSPGVGVAGVAAAPKGKERNGGTRLGVAGVPEDG 908

Human   909 EQPGWPSPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 973
            ||.||.|||||..||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   909 EQLGWSSPAKAVAVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDKD 973

Human   974 RPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGR 1038
            ||||||||||||||||||||||||.||||.|||||..|||.|.||||||||||.|.:|.|||.||
Mouse   974 RPRRVKPKCAPPPPPVMRLLQHPSTCSDPEEEPTAPPAGQHTPETQEGGKKAAPGPMPSSGKPGR 1038

Human  1039 PVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEP 1103
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse  1039 PVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSAITEP 1103

Human  1104 VPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNN 1168
            ||||||||||||||||||||||.||||||||||||||||||||||||||||.|||||||||||||
Mouse  1104 VPNSQLVDTGHQLLDYCSGYVDSIPQTRNKFAFREAVSKLELSLQELQVSSTAAGVPGTNPVLNN 1168

Human  1169 LLSCVQEISDVVQR 1182
            ||||||||||||||
Mouse  1169 LLSCVQEISDVVQR 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		42/45 (93%)
		CAP	2..106		95/103 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80		18/19 (95%)
		SH3_Abl	111..164	CDD:212784	52/52 (100%)
		SH2_ABL	169..262	CDD:198189	90/92 (98%)
		PTKc_Abl	281..543	CDD:270645	260/261 (100%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		23/23 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641		27/29 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674		19/19 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		1/1 (100%)
		F-actin-binding. /evidence=ECO:0000250	694..930		213/236 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794		30/30 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851		41/43 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024		53/59 (90%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		153/161 (95%)
		FABD	1063..1182	CDD:197885	115/118 (97%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		40/40 (100%)
		CAP	2..106		95/103 (92%)
		SH3_Abl	111..164	CDD:212784	52/52 (100%)
		SH2_ABL	169..262	CDD:198189	90/92 (98%)
		PTKc_Abl	281..543	CDD:270645	260/261 (100%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		23/23 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..642		27/29 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..674		18/18 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	659..661		1/1 (100%)
		F-actin-binding	695..930		213/236 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	765..796		30/30 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	809..858		46/48 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1059		83/94 (88%)
		F-actin-binding	1020..1182		153/161 (95%)
		FABD	1063..1182	CDD:197885	115/118 (97%)