Protein Alignment PABPC1 and pAbp

DIOPT Version :10

• Sequence 1: NP_002559.2
• Gene: PABPC1 / 26986
• HGNCID: 8554
• Length: 636
• Species: Homo sapiens
• Sequence 2: NP_476667.1
• Gene: pAbp / 37070
• FlyBaseID: FBgn0265297
• Length: 634
• Species: Drosophila melanogaster
• Alignment Length: 648
• Identity: 384/648 - (59%)
• Similarity: 459/648 - (70%)
• Gaps: 49/648 - (7%)

Human    10 MASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNF 74
            |||||||||..||.|:.|::|||.|||:||||||||:||||||||||||||||||||||||||||
  Fly     1 MASLYVGDLPQDVNESGLFDKFSSAGPVLSIRVCRDVITRRSLGYAYVNFQQPADAERALDTMNF 65

Human    75 DVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENG-SK 138
            |:::.||:||||||||||||:|||||:||||||::|||||:|||||||||||||||..||.| ||
  Fly    66 DLVRNKPIRIMWSQRDPSLRRSGVGNVFIKNLDRAIDNKAIYDTFSAFGNILSCKVATDEKGNSK 130

Human   139 GYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMD 203
            |||||||||:|||..:|:|:||||||.:||:||:|..|||||.|||.:||.|||||:|||.||.|
  Fly   131 GYGFVHFETEEAANTSIDKVNGMLLNGKKVYVGKFIPRKEREKELGEKAKLFTNVYVKNFTEDFD 195

Human   204 DERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKEL-NGKQIYVGRAQ 267
            ||:||:.|..:|...|.|||:.|.|||||||||:||..|.|:.||..:|||:: .||.:||.|||
  Fly   196 DEKLKEFFEPYGKITSYKVMSKEDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYVARAQ 260

Human   268 KKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMM-EGGR 331
            ||.|||.|||||||::||.|.....|||||||||||.|||:|||..|||:|.|||||||. |.||
  Fly   261 KKAERQQELKRKFEELKQKRHESVFGVNLYVKNLDDTIDDDRLRIAFSPYGNITSAKVMTDEEGR 325

Human   332 SKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPV 396
            |||||||||::..|||.||||:|||:|.:||||||||||||||:|||.:|||:.|..:|......
  Fly   326 SKGFGFVCFNAASEATCAVTELNGRVVGSKPLYVALAQRKEERKAHLASQYMRHMTGMRMQQLGQ 390

Human   397 INPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIA-QLRPSPRWTAQGARPHP-------------- 446
            |  |||...||:|:..:|..|.    :..||:| |:|.:|||..| .||..
  Fly   391 I--YQPNAASGFFVPTLPSNQR----FFGSQVATQMRNTPRWVPQ-VRPPAAIQGVQAGAAAAGG 448

Human   447 FQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVAN----------TSTQTMGPR---PAAAA 498
            ||...||: |...|...:..|.|..||....:....||          |..||..|.   |.|..
  Fly   449 FQGTAGAV-PTQFRSAAAGARGAQPQVQGTHAAAAAANNMRNTGARAITGQQTAAPNMQIPGAQI 512

Human   499 AAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQP-AVHVQGQ--EPLTASMLASAPPQEQKQ 560
            |..  |.:....|||.:.:|||     ..||:...|| ...:||:  |.|.||:||:|.||||||
  Fly   513 AGG--AQQRTSNYKYTSNMRNP-----PVPQLHQTQPIPQQLQGKNSEKLIASLLANAKPQEQKQ 570

Human   561 MLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAA 623
            :|||||:|:|:.||..||||||||||||:|||||||:|..|:|::||:|||||||.|:..|.|
  Fly   571 ILGERLYPMIEHMHANLAGKITGMLLEIENSELLHMIEDQEALKAKVEEAVAVLQVHRVTEPA 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PABPC1	NP_002559.2	PABP-1234	11..615	CDD:130689	378/637 (59%)
		CSDE1-binding	166..289		77/123 (63%)
		(Microbial infection) Binding to HRSV M2-1 protein. /evidence=ECO:0000269|PubMed:31649314	541..636		57/85 (67%)
pAbp	NP_476667.1	PABP-1234	2..625	CDD:130689	378/637 (59%)