DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Islr and kek6

DIOPT Version :9

Sequence 1:	XP_006511267.1	Gene:	Islr / 26968	MGIID:	1349645	Length:	436	Species:	Mus musculus
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	87/383 - (22%)
Similarity:	156/383 - (40%)	Gaps:	75/383 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 LCLLCWAVLLNLVRACPEPCDCGEKYGFQIADCAYRDLEGVPPGFPANVTTLSLSANRLPGLPEG 76
            |||:.|.|..:...:|...|.|....|.:.|.|:...|..:|......:..|.|:.|.:|.|...
  Fly    23 LCLVAWTVADDWSLSCASNCTCKWTNGKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNRE 87

Mouse    77 AFREVPL--LQSLWLAHNEIRSVAIGALAPLSHLKSLDLSHNLL-----SEFAWSD--------- 125
            .|..:.|  ||.::|..:|::.:...:...|..|..:|||.|.|     ..|..:|
  Fly    88 EFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNG 152

Mouse   126 --LHNLSALQ------LLKMDSNE--LAFIPRDAFSSLSALRSLQLNHNRLHALAEGTFAPLTAL 180
              |..|:|.|      |..:|.::  :::|...:.::|:.|..|.|.:|.|.:|:|..|..:..|
  Fly   153 NPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHMANL 217

Mouse   181 SHLQINDNPFDCTCGIVWFKTWALASAVSIPEQDNIACTTPHVLK------------GIPLGRLP 233
            ..|.:.:||:.|.|.:..|:.|.:.|.:|   ..::.|..|...|            |.|
  Fly   218 KTLSLEENPWQCNCKLRKFRGWYVNSRLS---SVSLVCKGPPAQKDRTWDSVDDELFGCP----- 274

Mouse   234 PLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPVPQLHWHIH---TPGGTVEIASPNVGT 295
                  |.|::.........::  |......|.|.|.|:|::.|.::   .....|...|.::.:
  Fly   275 ------PRVEIFNNEEVQNIDI--GSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESESIAS 331

Mouse   296 DGRALPGALATSGQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELGSAESSVNVALA 353
            |                :.::|  |.:.:...|:.|||:|..:|.:||...::::.|:
  Fly   332 D----------------KLWSN--LTVFNVTSLDAGTYACTGSNSIGSMTQNISIYLS 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Islr	XP_006511267.1	leucine-rich repeat	40..59	CDD:275380	4/18 (22%)
		LRR_8	59..118	CDD:338972	17/60 (28%)
		leucine-rich repeat	60..83	CDD:275380	6/22 (27%)
		leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		LRR_8	107..166	CDD:338972	20/82 (24%)
		leucine-rich repeat	108..131	CDD:275380	10/38 (26%)
		leucine-rich repeat	132..155	CDD:275380	5/30 (17%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		PCC	161..>235	CDD:188093	21/85 (25%)
		Ig	263..349	CDD:319273	19/88 (22%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:290566	13/58 (22%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR_4	144..186	CDD:289563	7/41 (17%)
		leucine-rich repeat	145..168	CDD:275380	4/22 (18%)
		leucine-rich repeat	169..216	CDD:275380	12/46 (26%)
		LRRCT	225..274	CDD:214507	12/51 (24%)
		Ig	295..367	CDD:143165	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910