Protein Alignment NBEA and BPH1

DIOPT Version :10

• Sequence 1: NP_001371941.1
• Gene: NBEA / 26960
• HGNCID: 7648
• Length: 2967
• Species: Homo sapiens
• Sequence 2: NP_009961.2
• Gene: BPH1 / 850398
• SGDID: S000000628
• Length: 2167
• Species: Saccharomyces cerevisiae
• Alignment Length: 2579
• Identity: 503/2579 - (19%)
• Similarity: 908/2579 - (35%)
• Gaps: 839/2579 - (32%)

Human   691 LILKDRGVKEDELQSILNYLLTMHEDENIHDVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLA 755
            :|...:|..||:|..:.||               ...||..    |.....|.||     :.:..
Yeast    64 IINSKKGTVEDDLCELNNY---------------TCFALSK----SFDLCHDSRN-----FNIAQ 104

Human   756 SKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLGERLMLHTNTVTVTTYNTLYEILTEQ 820
            .|.   |:|.|:.|   ...:.....|:|:.|.|..:|:.::.:.....:.:    .::|||:.
Yeast   105 PKR---WIQLLETL---TDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRI----RIFEILSN- 158

Human   821 VCTQVVHKPHPEPDS--TVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKLFSNSRENR 883
                       :.||  :..:|..:|...:..|..:.||    :|::.|:|...:| |.|...|.
Yeast   159 -----------KNDSWKSTLLQKNLIEWYIFMLSVDCTP----LELQNLYLHKELK-FCNGILNS 207

Human   884 RCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWVDTLSIAHSK 948
            ..|              .::...|:.....|..|.:|:|.....|.   ..:..:::..|:..::
Yeast   208 LTL--------------QVSDPRSQNYLQFENTYKLFQIQKSSRIN---NSFLFYIEFNSVTSNR 255

Human   949 V-TYEAH-----KE---------YLAKMYEEYQRQEEENIKKGKKGNVSTISGLSSQTTGAKGGM 998
            : |.|.|     ||         |:..::|.::      .:.|....:..:...:::.|....|.
Yeast   256 IMTIERHIYLEIKEGQFCISNDNYIIGLFENFE------FEAGTLYFIGVLIDHNNRITLYVDGS 314

Human   999 EIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVS-----DDILG------------------N 1040
            .|.::.....|....|      :.:...::.|.||.     |.:|.                  :
Yeast   315 MINQLTLFENSICQLS------TCELGSMICSIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFS 373

Human  1041 SDRPGSGVHVEVHDLLVDIKAEKV--EATEVK----LDDMDLSPETLVGGENGALVEVESLLDNV 1099
            ..:.|..|.....|.|: .||..:  ..||:.    :|:::             |:|:|:::.:|
Yeast   374 KKKEGPEVLSLCQDFLI-AKAHLMARPTTEISSTKYIDEIE-------------LLEMENIIIDV 424

Human  1100 YSAAVEKLQNNVHGSVGIIKKNEEKDNGPLITLADEKEDLPNSSTSFLFDKIPKQEEKLLPELSS 1164
            ....:  ||:....| ....|.||..|         .:::|.....:.:             .||
Yeast   425 NPNDI--LQDFTESS-NFTVKFEESTN---------SKNIPEVGKCYFY-------------RSS 464

Human  1165 NHIIPNIQDTQVHL--------GVSDDLGLLAHMTGSVDLTCTSSIIE--EKEFKIHTTSDGMSS 1219
            |.:...:....:.|        |..||  |..|::..::|.....|:.  :|:|.....:..:..
Yeast   465 NLVSKFVSIDSIRLAFLNMTESGSIDD--LFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQ 527

Human  1220 ISERDLASSTK-----------GLEYAEMTATTLETESSSSKIVPNIDAGSIISDTERSDDGKES 1273
            ...:||:....           |.::.:::.:.:....:...||.|:|...:..|......|
Yeast   528 KITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDAYENIVLNLDLWYMNEDQSSLASG--- 589

Human  1274 GKEIRK---IQTTTTTQA-VQGRSITQQDRDL----RVDLGFRGMPMTEEQRRQFSPGPRTTMFR 1330
            |.||.:   .|.::..:| :..:..:.:..|:    ::.|.::.:...|.|..:|:
Yeast   590 GLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFN--------- 645

Human  1331 IPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENIIFVH-----------NTIH 1384
                       .|.:||:....|   :.:|::.|..:.:        |:|           .:..
Yeast   646 -----------ELSSDLISVFVT---LLKSNTDKRHLQW--------FLHLSYYFIKRKDVRSTE 688

Human  1385 LISQMVDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVLVFAS 1449
            :|.|.||                        :|.:..:.|| |.|.| ..||.::.:..:|:...
Yeast   689 IILQAVD------------------------QLFSFYLDQG-SDENA-KILSEIIPLKLILMIMD 727

Human  1450 SLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNK------SSHGSSKPQEVP 1508
            .:      .|.|.|:   ...||.::..|.:.|....:|..::.|.|      ...|.|..:|:.
Yeast   728 QI------VENNESN---PITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEII 783

Human  1509 QSVTA------TAASK--TPLENVPGNLSPIKDPDRLLQDVDINRLR-AVVFRDVDDSKQAQFLA 1564
            ..:..      |.|::  :..|::.|.:|..|...:.:..:.:|.:. .|:..:..||.....|.
Yeast   784 SLLLTYSIGNYTTANEIFSGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLN 848

Human  1565 LAVVYFI----SVLMVSKYRDILEPQRE---TTRTGSQPGRNIRQEINSPTSTVVVIPSIPHPSL 1622
            ..::.|:    |:..|.....:.:|::.   .:........|..::|:...|:..||..:    :
Yeast   849 NHILRFVEDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISEL----I 909

Human  1623 NHGFLAKLIPEQSFGHSFYKET--------PAAFPDTIKEKETPTPGEDIQVESSIPHTDSGIGE 1679
            ....:..|....::....|..|        ...:|.|:..
Yeast   910 KGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMN------------------------- 949

Human  1680 EQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVK 1744
                   |.:.||.|.....:.|:|:.|                           :.....:|:.
Yeast   950 -------NSSYLELSFIVTLLPEILNDL---------------------------VDSNNNLNLM 980

Human  1745 EILKSLVAAPVEIAECGPEPIPY-------------PDPALKRETQAILPMQFH----------- 1785
             :||.                ||             ||     .:|.::|..|:
Yeast   981 -MLKH----------------PYTMSNLLYFLRKFRPD-----TSQIVMPKDFYFSSYTCLLHCV 1023

Human  1786 -SFDRSVVVPVKKPPPGSL-------AVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGA 1842
             ..|:|.....|......|       .:..:.:.|....:.......:|:.:....:.::...||
Yeast  1024 IQIDKSSFYHFKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESLMAHQEVLFAHGA 1088

Human  1843 VDSGSSSSSSSSSFVNGATSKNLPAVQTV-------APMPEDSAENMSITAKLERALEKVAPLLR 1900
            .|:                       :||       |....|...|.::...::..::.....|:
Yeast  1089 CDN-----------------------ETVGLLLIFFANRLRDCGYNKAVFNCMKVIIKNKERKLK 1130

Human  1901 EIFVDFAPFLSRTLLGSHGQELLIEG----LVCMKSSTSVVELVMLLCSQEWQNSIQKNAGLAFI 1961
            |:...|.|        ::..|:| ||    |.|..|.|      |.|.::::.........:.||
Yeast  1131 EVACFFDP--------ANKSEVL-EGLSNILSCNNSET------MNLITEQYPFFFNNTQQVRFI 1180

Human  1962 ELI--------NEGRLLCHAMKDHIVRVAN-EAEFILNRQ-------RAEDVHKHAEFESQCAQY 2010
            .::        |...:....:|:.:....| .:|::....       |.::.....:.:...::|
Yeast  1181 NIVTNILFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDFKIKKSISRY 1245

Human  2011 A----ADRREE----EKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWR 2067
            .    .||.|.    ....:.||...||            .|.|.:|.:.:..          |.
Yeast  1246 TYNLKTDREENAVFYRNNLNLLIFHLKH------------TLEIQSNPNSSCK----------WS 1288

Human  2068 LDYWEDDLRRRRRFVRNAFGSTHAEALLKAAIEYGTEEDV-----------------------VK 2109
            .|:.||....:||.: .|:...: |.|:       .|||.                       ::
Yeast  1289 SDFAEDFDGMKRRLL-PAWEPKY-EPLI-------NEEDANQDTITGGNRQRRESGSILSYEFIE 1344

Human  2110 SKKTFRSQAI--VNQNAETELMLEGDDDAVSLLQEKEIDNLAGPVVLSTPAQLIAPVVVAKGTLS 2172
            ..:|..|:.:  :|:|.:. |.|..|:|:::.:..               ..||..:.:.:|.|.
Yeast  1345 HMETLESEPVGDLNENRKI-LRLLKDNDSIATIWN---------------CSLIIGLEIKEGILI 1393

Human  2173 ITTTEIYFEVDEDDSAFKKIDTKVLAYTEG-----------LHGK---------------WMFSE 2211
            ..:..:||   ..|..|...|.|:|..:|.           ::|.               |...:
Yeast  1394 HGSNYLYF---VSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLD 1455

Human  2212 IRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQAT---VKKVVYSLP------------------ 2255
            |..|..|.:||::.|:|:....|.|..|:|.::..   |.:|:..:|
Yeast  1456 ITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEIND 1520

Human  2256 -------RVGVGTSYGLPQARRISLATP-RQLYKSSN-------MTQRWQRREISNFEYLMFLNT 2305
                   |.|:|         :.|:|:. ..::.::|       ::::|.|.|||||.||:.:|.
Yeast  1521 RGNSIVARNGIG---------KASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINI 1576

Human  2306 IAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYE---TWED 2367
            :|||::|||.||||||||:.:|||..|||..|..:||||||:||.:.||.:.:.||||   :.|:
Yeast  1577 LAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLEN 1641

Human  2368 DQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRT-SQRDTSDV 2431
            ..|.|:||.||||:|....|:|:|::||...||....|.|...||.|||:.|:|.: |..:|:||
Yeast  1642 ADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDV 1706

Human  2432 KELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLH 2495
            :||.|||::|||..:|.|.|:.|..:....|:||.|||||. .|:.|::.||.||||.:||..||
Yeast  1707 RELTPEFFFLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLH 1771

Human  2496 QWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIK 2560
            :||||||||||:|..||:::|||:.|:|.|:||||:|.|...|                     :
Yeast  1772 EWIDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENER---------------------R 1815

Human  2561 AMEAQIQNFGQTPSQLLIEPHPPRSSAMHLC-----------FLPQSPLMFK-----DQMQQDVI 2609
            |:...|.||||||.|:..||||.:.:    |           .:|..|:..|     ::..:.|.
Yeast  1816 AITGIIHNFGQTPLQIFQEPHPEKIA----CNVQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVD 1876

Human  2610 MVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEM 2674
            .|:..||.....:......|:|......::...|:...| |                   |.|.:
Yeast  1877 YVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKN-W-------------------LKIGL 1921

Human  2675 DPLIANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGFWDKSFRVYSTETGKLTQIVFG 2739
            |                     |....|...:|:                             |.
Yeast  1922 D---------------------IFKKTHMAQITS-----------------------------FA 1936

Human  2740 HWDVVTCLARSESYIGGDCYIVSGSRDATLLLW-YWSGRHHIIGDNPNSSDYPAPRAVLTG---- 2799
            :|.:            |:  .::|.::..:.:| |...:|.:.|:..|       :..:.|
Yeast  1937 YWKL------------GE--FITGDKNGLIKVWKYRKDKHSVSGNLEN-------KKTMFGHLCE 1980

Human  2800 -------HDHEVVCVSVCAELGLVISGAKEGPCLVHT---ITGDLLRALEGPENCLFPRLISVSS 2854
                   ||:..:       |.|.|||      ||:.   |..:|:|.:...     .:.:::|.
Yeast  1981 LKEMRCYHDYNTL-------LTLDISG------LVYVWDMINFELVRQITND-----AQKVAISQ 2027

Human  2855 E-GHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVWQACDFKQL 2918
            . |..::..:....|.|::||::....:...:.                   :|......||.:|
Yeast  2028 HAGSIMVLTKNNAISIFNLNGQIYTSKKFEPAK-------------------IVSSIDFFDFTKL 2073

Human  2919 YIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYE 2962
                  |||.|......:...|:.|...|:|..:.: |..:|.|
Yeast  2074 ------DAGYRKHIYWKEMEILLVGFEDGTIEIYEL-FLNFHNE 2110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NBEA	NP_001371941.1	Laminin_G_3	255..402	CDD:463865
		DUF4704	467..947	CDD:464870	48/257 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..995		2/23 (9%)
		WD 1. /evidence=ECO:0000305	1326..1368		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1531		10/54 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1651..1675		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1711..1731		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1841..1860		3/18 (17%)
		DUF1088	1966..2132	CDD:461925	33/206 (16%)
		PH_BEACH	2158..2255	CDD:434260	27/125 (22%)
		Beach	2287..2584	CDD:460459	146/301 (49%)
		NBCH_WD40	2684..2956	CDD:466575	43/287 (15%)
		WD 2. /evidence=ECO:0000305	2739..2782		6/43 (14%)
		WD40 repeat	2745..2799	CDD:293791	7/54 (13%)
		WD 3. /evidence=ECO:0000305	2799..2839		13/53 (25%)
		WD40 repeat	2804..2839	CDD:293791	10/37 (27%)
		WD40 repeat	2844..2873	CDD:293791	4/29 (14%)
		WD 4. /evidence=ECO:0000305	2881..2920		4/38 (11%)
		WD40 repeat	2882..2920	CDD:293791	4/37 (11%)
		WD 5. /evidence=ECO:0000305	2923..2962		10/38 (26%)
		WD40 repeat	2928..2954	CDD:293791	5/25 (20%)
BPH1	NP_009961.2	PH_BEACH	1371..1500	CDD:275391	28/146 (19%)
		Beach	1558..1839	CDD:214982	146/301 (49%)
		WD40 repeat	1933..1976	CDD:293791	10/92 (11%)
		WD40 repeat	1981..2017	CDD:293791	12/48 (25%)
		WD40 repeat	2021..2055	CDD:293791	6/33 (18%)