DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NBEA and lvs1

DIOPT Version :10

Sequence 1:	NP_001371941.1	Gene:	NBEA / 26960	HGNCID:	7648	Length:	2967	Species:	Homo sapiens
Sequence 2:	NP_595759.2	Gene:	lvs1 / 2540571	PomBaseID:	SPBC28E12.06C	Length:	2609	Species:	Schizosaccharomyces pombe

Alignment Length:	2788	Identity:	607/2788 - (21%)
Similarity:	1012/2788 - (36%)	Gaps:	891/2788 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   672 PSQK----EIISLRAFM-----LLFLKQLILKDRG-------VKEDELQSILNYLLTMHEDENIH 720
            ||:|    |:..||.|:     ..|..||.:.|.|       |.:...||:|:.
pombe    22 PSEKVLLEELRKLRGFIRNDIPSNFFPQLFITDNGFAAIKKAVTKLNFQSLLSL----------- 75

Human   721 DVLQLLVALMSEHPASMIPAFDQRNGIRVIYKLLAS-----KSESIWVQ-ALKVLGY-------- 771
            |:.:..:.::               ||...|.:|.|     |....|:: |::.:.|
pombe    76 DIFECCLQIL---------------GIATSYTILRSWLLSRKHIEAWIELAIRRMFYSFCAIQDD 125

Human   772 ---FLKHLGHKRKVE-----IMHTHSLFTLLGERLMLHTNTVTVTT---YN-TLYEILTEQVCTQ 824
               .:..:|...|.:     ......|.:...:.:...:.||::::   |: ...::...::|:.
pombe   126 SNISIYAIGTSSKTDSSIQAASPNEDLKSEGAQEIDSQSETVSISSDVDYDEDRKDLKKAKICSA 190

Human   825 VVHKPH--------PEPDSTVKIQNPMILKVVATLLKNSTPSAELMEVRRLFLSDMIKL------ 875
            ...|..        .:.|||..     :||:|.:|..|:  :|.|:|:.|:..:.:.||
pombe   191 YYLKTRLLLAVLSFAQNDSTFS-----LLKLVPSLQDNT--NASLVELSRVVEAAIQKLSIKPLA 248

Human   876 FSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFRILLYHAIKYEWGGWRVWV- 939
            |.|...  :.||.|              |..|           ||.::|.|.        |..:
pombe   249 FPNVLP--QVLLLC--------------PSIS-----------IFNLILLHL--------RALIR 278

Human   940 ----DTLSIAHSK-----VTY-----------EAHKEYL-----------------AKMYEEYQR 967
                :.:.|.:||     :||           :..|:.|                 ||:...|.:
pombe   279 SSPENAIKIGYSKTMHFLLTYLFEPPTSFPLSDVSKDLLNEITLHCATFGVSNASTAKVLRTYLK 343

Human   968 QEEENIK----KGKKGNVSTISGLSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDL- 1027
            .:.|.::    |.....|:.....:..|.|                   .|..|:.:|:....:
pombe   344 TKSEFLRTWLLKALSHLVAPSFYFNPSTKG-------------------YSSIDFTLSSPVMPIN 389

Human  1028 --LMSTKVSDDILGNSDRPGSGVHVEVHDLLVDIKAEKVEATEVKLDDMDLSPETLV----GGEN 1086
              .:|..::.:.|.|.|    |.:......|:   ::.:::|..:| .:|.|.:|:|    ..::
pombe   390 GYSVSLWLNIESLMNDD----GNYAPTTLFLI---SDFLKSTLFRL-LLDASKKTVVVHIGSSKD 446

Human  1087 GALVEVESLLDNVYSAAVEKLQNNVHGSVGIIKKNEEKDNGP---LITLA--DEKEDLPNSST-- 1144
            ..:|...:.:.|.:|.               |.|:....|.|   ||||.  :||..|||...
pombe   447 TCVVNFSTPITNFFSK---------------IYKDNPSLNPPSWHLITLVHRNEKSSLPNLELYI 496

Human  1145 ------------SFLFDKIPKQEEKLLPELSSNH------IIPNIQDTQVHLGVSDDLGLLAHMT 1191
                        .||...:......|.|.:.|.:      :.||:.:|...  ||::.|..:..|
pombe   497 DGSAVERAACPYPFLSSTLQPLYVSLGPSIGSRNQSTPSTLAPNVAETDAL--VSENTGAASQKT 559

Human  1192 GSVDLTCTS---------SIIEEKEFKIHTTSDGMSSISERDLASSTKG---------LEYAEMT 1238
            .....|..|         .|...:.|.:...|..::.||  .|..|..|         :.|...|
pombe   560 SKSYKTNDSLKVPPLVPLLIGTTRFFPVPLVSSQIAIIS--SLGPSYSGCFQGPINDYMTYKAST 622

Human  1239 ATTLETESSSSK---IVPNIDAGS--------------IISDTERSDDGKESGKE-IRKIQTTTT 1285
            |.|||.:.|.|.   ::.:|.|.|              .|.|.:.||....|..| ::|::....
pombe   623 ALTLEIQDSKSNTEDLLHSIQAFSRSPIAFMSCARDYVDIMDLQLSDFCSFSVLETLKKLENQYY 687

Human  1286 TQAVQGRSITQQDRDLRVDLGFRGMPMTEEQRRQFSPGPRT--TMFRIPEFKWSPMHQRLLTDLL 1348
            :.....|:::..|:....:....|:          |.|..|  .|..|.:..::.....:|.:|:
pombe   688 SHVYINRAVSSYDKAFSAEQPSFGV----------SSGSVTPIIMQSISDAIYNIGGSSILLELV 742

Human  1349 FALETDVHV--------------WR-------SHSTKSVMDFVNSNENIIFVHNTIHLISQM--- 1389
            ...||:..:              ||       :||.:.:...::|..:::....|:.:|:.|
pombe   743 GTAETEAELNFGLQVFFSSIEDNWRFSENVEQTHSFEILAQILHSKSHLLVSEETLKIIALMSGV 807

Human  1390 ---------VDNIIIACGGILPLLSAATSPTGSKTELENIEVTQGMSAETAVTFLSRLMAMVDVL 1445
                     |.|.::....||..      ...||....|:.|.|          |..:::::
pombe   808 HHTRFKHPLVMNPLLFRYLILDF------DLWSKAPNSNLFVQQ----------LGYIVSLI--- 853

Human  1446 VFASSLNFSEIEAEKNMSSG----GLMRQCLRLVCCVAVRNCLECRQ------------------ 1488
                         |.|..:|    .||:..:......|:||||..:.
pombe   854 -------------ENNDYAGFNVKRLMKMQILKKLLTAMRNCLFHKDLLPILRLLFKVLMTSAFV 905

Human  1489 RQRDRG-------NKSSHGSSKPQEVPQSVTATAASKTPLENVPGNLSPIKDP---------DRL 1537
            .:..|.       ...:.|.|||  :.:|..:.|..::     ..|...||:.         |.|
pombe   906 SENIRSVATYIIYASQATGKSKP--IRRSSVSIAVDRS-----DSNYISIKESGYAICEEFIDLL 963

Human  1538 LQDVD----INRLRAVV--------FRDVDD----------------------SKQAQ-FLALAV 1567
            ::...    :.|..:::        .|..|.                      ||.:| |....:
pombe   964 IKSNGEPSFLRRFSSMITPAWLLFLLRQQDIHYFICGIRLLNQSICSLGSSFLSKFSQKFHGFLI 1028

Human  1568 VY------------FISVLMVSKYRDILEPQRETTRTGSQP-GRNIRQEINS--PTSTVVVIPSI 1617
            ::            ::::|.:|....|...|..|..|..|. ...::.|:::  |.|.|
pombe  1029 LHDNLKDHIHLEELWLNLLFLSLGLGIRSVQFRTDLTYKQKLDFVLKNELDNILPLSEV------ 1087

Human  1618 PHPSLNHGFLAKLIPEQSFGHSFYKETPAAF---PDTIKEKETPTPGEDIQV----ESSIPHTDS 1675
             .|||.|...|.|....:.......|..||.   .||:....|      :|.    |.::.:..|
pombe  1088 -FPSLFHAIQATLEKVSNVNGKLNSENVAALRYADDTMSFLVT------LQTTYSFELTLNYDFS 1145

Human  1676 GIGEEQVASILNGAELETSTGPDAMSELLSTLSSEVKKSQESLT--ENPSETLKP---ATSISSI 1735
            .:..:.|...|  :.::|.|....|.:||..:...:.:|..|.|  |...::::.   :.|...:
pombe  1146 ELLTKVVFPFL--SPVDTITAEQEMRDLLHNIRQPLPRSSSSKTFGEGIKKSVRKFSMSGSFKRV 1208

Human  1736 SQTKGINV-KEILKSLVAAPVEIAECGPEPIPYPDPALKRETQAILPMQFHSFDRSVV--VPVKK 1797
            ....|..: |:||...: ..:|.........|..|.||:            .||...|  ...|.
pombe  1209 VTPLGTQLRKDILNDSI-TDMENTSSFTASFPQSDQALQ------------YFDNFTVQYAEAKD 1260

Human  1798 PPPG---SLAVTTVGATTAGSGLPTGSTSNIFAATGATPKSMINTTGAVDSGSSSSSSSS----- 1854
            ...|   |:........|:|.|.   |.|.:..   ..|.|.|.......||...|:.|.
pombe  1261 VIKGLLFSILTCIYNRITSGQGF---SYSRLLV---YLPPSQIEKKSTFFSGILRSTMSKLIEAV 1319

Human  1855 -----------------------------SFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLER 1890
                                         .::.|:.   |..|..:..:.|:........|||.:
pombe  1320 KNDKLLLAEPSILANISYIFTKFIRMHLLGYLKGSW---LEIVDDLGSLLEEIISRPDFLAKLPK 1381

Human  1891 ALEKVAPLLREIFVDFAPFL--------------SRTLLGS--HGQELLIEG------------- 1926
            .....|..:...|:|.  ||              |..::.|  :.|.||...
pombe  1382 NGRNAAMNMYSCFLDL--FLLEVSDLKQTECNAQSDKIIKSITYWQSLLFNSKTYQKDLFSLLWY 1444

Human  1927 --LVCMKSSTSVVEL-------VMLLCSQEWQNSIQKNAGLAFIELINEGRL---LCHAM---KD 1976
              .:.::::|.||.|       ::.|.|..:.:.|.|...       |:.|.   :|..:   .|
pombe  1445 AVYIMVETTTGVVRLQAVDAWRLLFLHSPGYLSDIAKTCN-------NDPRFAYEICKTLDNDSD 1502

Human  1977 HIVR-----VANEAEFILN--RQRAEDV----HKHAEFESQCAQYAADRREEEKMCDHLI----- 2025
            ..||     .|...:|:|:  ..|.||.    ||.|:.|:...|::......:::..:..
pombe  1503 KFVRWLDDNAAEVNQFMLSCFFCRWEDFLKQQHKLADEEASLLQFSRLEHLRKQLAQNTFNENIL 1567

Human  2026 ---SAAKH------------------------RDHVTANQLKQKILNILTNKHGAWGAVSHSQLH 2063
               ||:.|                        .:.|.|..|.||  |.|::::...|:.:.|
pombe  1568 NESSASYHVWISSLFALECNRFKKMSQDQSDQENFVAAALLSQK--NELSHENSILGSKTTS--- 1627

Human  2064 DFWRLDYWEDDLRRRRRFVRNAFGSTHAEALLKA---------AIEYGTEEDVVKSKKTFRSQAI 2119
              |.||..|...|.|:|.:.....|:..::.|:|         :.:...|..|..:.:..::..:
pombe  1628 --WELDSTEGSERMRKRLMPCLLQSSELDSKLEARSSGARRNRSFDTSVEAPVSLTNEEKQAATL 1690

Human  2120 VNQNAETEL----------MLEGDDDAVSLLQEKEIDNLAGPVVLSTPA----------QLIAPV 2164
            :..:.|..|          .:|.::|.|. .::||..|..  |:.|..:          ..|..:
pombe  1691 ILPSQEETLHDAARSDSNNSMEDEEDDVD-EEDKEDKNRT--VMRSIESGDSIQDVYNVSRIFGL 1752

Human  2165 VVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVL------------AYTEGLH-------GK---- 2206
            ...:|.|.:....:|..    |:.|.:.|.:::            .|.:.||       ||
pombe  1753 EATEGILLLGKQYLYLM----DNFFLRSDNEIVDVNDNSIIDERDPYLQLLHLQSLSSSGKVRRH 1813

Human  2207 --------WMFSEIRAVFSRRYLLQNTALEVFMANRTS---VMFNFPDQATV-KKVVYSLPRVGV 2259
                    |.|.::..|..|.|||::..||:|..:..|   ::.|..::.:: :|:|...|...|
pombe  1814 ISKENNWHWDFIDLSLVLKRFYLLRDVGLELFFKDGRSFLTILSNTKNRDSLYQKLVARAPGADV 1878

Human  2260 -GTS-YGLPQARRISLATPRQLYKSSNM------------TQRWQRREISNFEYLMFLNTIAGRT 2310
             .|| :....:|.:..|..:..:.||.:            |:||:|||||||.||..:||:||||
pombe  1879 LSTSHFATSMSRDLGKANGKSNFLSSKLANALSFSTTHPATKRWERREISNFNYLQIVNTLAGRT 1943

Human  2311 YNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERYET---WEDDQSPP 2372
            ||||.||||||||:.:|.|:||||..|..:|:..||:||.:|:|...:.|||:.   ..|.|..|
pombe  1944 YNDLTQYPVFPWVIADYTSKELDLNNPKTYRNFCKPMGAQHPERESQFNERYDLLLGLNDSQQQP 2008

Human  2373 YHYNTHYSTATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDT-SDVKELIP 2436
            :||.||||:|....|:|:|:.||...:|....|:|||.||.|.|:.::||:|.::. :||:||||
pombe  2009 FHYGTHYSSAMIVCSYLIRLRPFVDSYLALQGGQFDHADRLFYSIEQAWRSSSKENMADVRELIP 2073

Human  2437 EFYYLPEMFVNSNGYNLGVREDE-VVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQWID 2499
            ||:||.|||:|.||::.|.|:.| ..:|||.|||||| .|..||:.||.||||::||..||:|||
pombe  2074 EFFYLSEMFINGNGFDFGSRQKESTPINDVILPPWAKGDPAIFVQKNREALESKYVSAHLHEWID 2138

Human  2500 LIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEA 2564
            |:||.||||.|||.|.||||:|:|:|:::|::|.:..  |:..|..|
pombe  2139 LVFGCKQRGDEAVAATNVFHHLSYQGAIDLENIENEF--ELAAAVGI------------------ 2183

Human  2565 QIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPLM---FKDQMQQDVIMVLKFPSNSPVTHVAAN 2626
             |.||||||.|:..:|||.|..  .....|..|.:   |:|.:.      |.|.|.||:..:
pombe  2184 -IHNFGQTPKQVFKKPHPQRGP--DFTDTPLGPYLFGRFEDSIH------LLFQSCSPIIRI--- 2236

Human  2627 TLPHLTIPAVVTVTCSRLFAVNRWHNTVGLRGAPGYSLDQAHHLPIEMDPLIANNSGVNKRQITD 2691
                          |.::                      ||   |:.||        :|.::..
pombe  2237 --------------CKKV----------------------AH---IQYDP--------SKDEVGA 2254

Human  2692 LVDQSIQINAHCFVV--TADNRYILICGFWDKS---FRVYSTETGKLTQIVFGHWDVVTCLARSE 2751
            .......:..:.|:.  ..||...||....||.   |....:|  |:|.       ||.|..|:
pombe  2255 FAADYTPLGPNTFLAWGRVDNTVQLISDQLDKQPVMFEELHSE--KITH-------VVACDERT- 2309

Human  2752 SYIGGDCYIVSGSRDATLLLWYWSGRHHIIGDNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLV 2816
                    .::.|.|.||.||..|         .|.....:.:.||.||.:.:.||:||....::
pombe  2310 --------FLTASLDLTLRLWTLS---------TNKPIKASLKRVLYGHRYRITCVTVCKAFSII 2357

Human  2817 ISGAKEGPCLVHTITGDLLRALEGPENCLFPRL-------------ISVSSEGHCIIYYERGRFS 2868
            :||...|    :.|..||.|| |...:....:|             |:.|:..:|.:
pombe  2358 VSGDAGG----NLIIWDLNRA-EFVSSLSVYKLPIQTIAVNARNAEIAFSTGFYCCV-------- 2409

Human  2869 NFSINGKLLAQMEIN-----DSTRAILLSS--DGQN--------LVTGGDNGVVEVWQ 2911
             .::|||:|.:.:::     :|...||.|.  .|.|        .:||..:|::.:|:
pombe  2410 -VNVNGKILVKDKLSRIYNENSDENILCSCFYTGANSEWLHKNLFITGHPDGIIRIWE 2466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NBEA	NP_001371941.1	Laminin_G_3	255..402	CDD:463865
		DUF4704	467..947	CDD:464870	61/335 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..995		5/27 (19%)
		WD 1. /evidence=ECO:0000305	1326..1368		11/64 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1531		8/47 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1651..1675		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1711..1731		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1841..1860		4/52 (8%)
		DUF1088	1966..2132	CDD:461925	42/233 (18%)
		PH_BEACH	2158..2255	CDD:434260	26/141 (18%)
		Beach	2287..2584	CDD:460459	151/302 (50%)
		NBCH_WD40	2684..2956	CDD:466575	59/261 (23%)
		WD 2. /evidence=ECO:0000305	2739..2782		11/42 (26%)
		WD40 repeat	2745..2799	CDD:293791	12/53 (23%)
		WD 3. /evidence=ECO:0000305	2799..2839		14/39 (36%)
		WD40 repeat	2804..2839	CDD:293791	12/34 (35%)
		WD40 repeat	2844..2873	CDD:293791	4/41 (10%)
		WD 4. /evidence=ECO:0000305	2881..2920		10/46 (22%)
		WD40 repeat	2882..2920	CDD:293791	10/45 (22%)
		WD 5. /evidence=ECO:0000305	2923..2962
		WD40 repeat	2928..2954	CDD:293791
lvs1	NP_595759.2	Laminin_G_3	380..534	CDD:463865	34/176 (19%)
		DUF4704	715..>882	CDD:464870	33/198 (17%)
		PH_BEACH	1738..1871	CDD:275391	25/136 (18%)
		Beach	1919..2202	CDD:214982	152/303 (50%)
		WD40	2255..>2466	CDD:475233	57/251 (23%)
		WD40 repeat	2255..2294	CDD:293791	8/38 (21%)
		WD40 repeat	2300..2340	CDD:293791	15/64 (23%)
		WD40 repeat	2345..2398	CDD:293791	14/57 (25%)
		WD40 repeat	2406..2435	CDD:293791	6/37 (16%)
		FYVE_like_SF	2556..2600	CDD:277249
Blue background indicates that the domain is not in the aligned region.

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NBEA and lvs1

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.