DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NBEA and sel-2

DIOPT Version :10

Sequence 1:NP_001371941.1 Gene:NBEA / 26960 HGNCID:7648 Length:2967 Species:Homo sapiens
Sequence 2:NP_001379017.1 Gene:sel-2 / 175606 WormBaseID:WBGene00004760 Length:2563 Species:Caenorhabditis elegans


Alignment Length:2917 Identity:1085/2917 - (37%)
Similarity:1545/2917 - (52%) Gaps:629/2917 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    91 IVETVLNLLVGGEFDLEMNFIIQDAESITCMTELLEHCDVTCQAEIWSMFTAILRKSVRNLQTST 155
            :|:.:.||||||.||.|..|:|:||.::..|..||.|||...|.||||:|.|:::||.|||:..|
 Worm   220 VVDNLFNLLVGGHFDQESKFVIEDAANVDHMLTLLSHCDYDLQNEIWSLFLAVMKKSNRNLEACT 284

Human   156 EVGLIEQVLLKMSAVDDMIADLLVDMLGVLASYSITVKELKLLFSMLRGESGIWPRHAVKLLSVL 220
            .||||.:||..:.....::|||||.::..|.:|||.||:.|.|...|:.....||.:::|||.||
 Worm   285 RVGLISKVLDILPEAPPLLADLLVQIIAALVAYSINVKQTKHLLRALKSTKEQWPPNSLKLLHVL 349

Human   221 NQMPQRHGPDTFFNFPGCSAAAIALPPIAKWPYQNGFTLNTWFRMDPLNNINVDKDKPYLYCFRT 285
            .:|||....|.||:|||...:.|.||||...|||.|:|..||.||:|||::..:|::|.||.|||
 Worm   350 KEMPQHDSADVFFSFPGKDQSGIILPPIKTMPYQQGWTFATWLRMEPLNSVTFEKEQPVLYSFRT 414

Human   286 SKGVGYSAHFVGNCLIVTSLKSKGKGFQHCVKYDFQPRKWYMISIVHIYNRWRNSEIRCYVNGQL 350
            |||||||.||.||||:|...|:|||....||:.:...|||:.|:|.|.|:||..|:|:|:::|||
 Worm   415 SKGVGYSCHFTGNCLVVNVEKTKGKEQSRCVRAELGARKWHHIAIAHCYSRWGRSDIKCFIDGQL 479

Human   351 VSYGDMAWHVNTNDSYDKCFLGSSETADANRVFCGQLGAVYVFSEALNPAQIFAIHQLGPGYKST 415
            ....:::|.|.:..::|:|.:|.|....||..||||:||:|:|:|||...|..::..|||.|:||
 Worm   480 AETIELSWVVTSATNWDRCSIGVSADGTANSAFCGQMGAMYLFAEALTLQQANSLFCLGPVYQST 544

Human   416 FKFKSESDIHLAEHHKQVLYDGKLASSIAFTYNAKATDAQLCLESSPKENAS-IFVHSPHALMLQ 479
            ||..||:.  |.|.:|:.|:||.|.||:.|.|..|....||||.:.||..|| .||..|||:|.:
 Worm   545 FKHDSETS--LPEGYKKHLFDGHLHSSLVFAYCPKNCHGQLCLYTPPKTAASTYFVQIPHAVMKE 607

Human   480 DVKAIVTHSIHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVELLKSSVAMQEQ 544
            .|:.|.|||||.::.|:||||:|.|||||:|....||:.::..||.|||:.:..||.||.:.|:|
 Worm   608 GVEVITTHSIHKSLQSVGGIQILLPLFAQIDLPSSNDNSIDGEVCQTLLSLIALLLSSSQSSQQQ 672

Human   545 MLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLDGLSHGAPLLKQLCDHILFNPAIWIHTP 609
            :...||||:|...|:|:|..|::..||||.:..||:|.....|.||||.|.|:|||||.:||...
 Worm   673 LFHSKGFLIISSCLQKASPSHLSMKVLEQLIHIAKFLLRCPAGGPLLKHLFDYILFNPKLWIRAR 737

Human   610 AKVQLSLYTYLSAEFIGTATIYTTIRRVGTVLQLMHTLKYYYWVINPADSSGITPKGLDGPRP-- 672
            .:||:.||.||:.:|:........:|||.||:::.||||::||:..|...|..|.:    .||  
 Worm   738 PEVQVHLYQYLATDFLANNNFSQMLRRVPTVIEMCHTLKHFYWLALPQTVSDYTIE----ERPEN 798

Human   673 -SQKEIISLRAFMLLFLKQLILKDRG------VKEDELQSILNYLLTMHEDENIHDVLQLLVALM 730
             :..:|:::|:.:|.|:.::|:...|      |::.|:.::||.|.|:.||:|::|||.|:..|:
 Worm   799 FATADIVAIRSSILTFINRIIIASAGPEEEERVRDQEVHTLLNLLATVREDDNLYDVLALVTRLL 863

Human   731 SEHPASMIPAFDQRNGIRVIYKLLASKSESIWVQALKVLGYFLKHLGHKRKVEIMHTHSLFTLLG 795
            :||||.||||.|:...:.:|:.|||:.:|.|.:.|||:||:||.....|||.|.|...:||:|:|
 Worm   864 AEHPAIMIPAIDKNKALGIIFNLLAAPNELIRIPALKILGFFLSRSTLKRKTESMGNQNLFSLIG 928

Human   796 ERLMLHTNTVTVTTYNTLYEILTEQVC---TQVVHKP-HPEPDSTVKIQNPMILKVVATLLKNST 856
            |||:.|...:::.|||.|.|||.||:.   |...|:| .||    .|.:||.:|||:|.::....
 Worm   929 ERLLSHKKVLSLPTYNVLLEILVEQMTPTFTYACHQPAQPE----WKFENPHLLKVIAHVISQCE 989

Human   857 PSAELMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGYINPKNSEEQKITEMVYNIFR 921
            .|..::::::.||.|:|.|...|:||||.:||.||||||:..|.|:......:.:::|:|:..|.
 Worm   990 ESENIVQIKKCFLIDIINLCRESKENRRTILQMSVWQDWLIGLAYVFHTTESQNEVSELVWEAFS 1054

Human   922 ILLYHAIKYEWGGWRVWVDTLSIAHSKVTYEAHKEYLAKMYEEYQRQEEENIKKGKKGNVSTISG 986
            |||:||::.|:||||||||||:||||||::|..|..||:                          
 Worm  1055 ILLHHALRNEYGGWRVWVDTLAIAHSKVSFEKFKRKLAE-------------------------- 1093

Human   987 LSSQTTGAKGGMEIREIEDLSQSQSPESETDYPVSTDTRDLLMSTKVSDDILGNSDRPGSGVHVE 1051
                   ||                                                        
 Worm  1094 -------AK-------------------------------------------------------- 1095

Human  1052 VHDLLVDIKAEKVEATEVKLDDMDLSPETLVGGENGALVEVESLLDNVYSAAVEKLQNNVHGSVG 1116
                   ||||:.|:                |||                               
 Worm  1096 -------IKAERSES----------------GGE------------------------------- 1106

Human  1117 IIKKNEEKDNGPLITLADEKEDLPNSSTSFLFDKIPKQEEKLLPELSSNHIIPNIQDTQVHLGVS 1181
                                                  |.|:.|                     
 Worm  1107 --------------------------------------EAKMEP--------------------- 1112

Human  1182 DDLGLLAHMTGSVDLTCTSSIIEEKEFKIHTTSDGMSSISERDLASSTKGLEYAEMTATTLETES 1246
                                                                             
 Worm  1113 ----------------------------------------------------------------- 1112

Human  1247 SSSKIVPNIDAGSIISDTERSDDGKESGKEIRKIQTTTTTQAVQGRSITQQDRDLRVDLGFRGMP 1311
                                                                             
 Worm  1113 ----------------------------------------------------------------- 1112

Human  1312 MTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALETDVHVWRSHSTKSVMDFVNSNENI 1376
                          |.::|.|||.||.:|.|||.|||..:|..|..|:. :...:.|..|::||.
 Worm  1113 --------------TPIYRAPEFAWSDVHVRLLADLLSGIERVVDEWKV-AECGISDQCNASENQ 1162

Human  1377 IFVHNTIHLISQMVDNIIIACGGILPLLSAATSPTGSKTELENIE-VTQGMSAETAVTFLSRLMA 1440
            :||.|.:|::||:.|::|:||||:||||::||:|   ..::|.:: ..|.:....:..||.|...
 Worm  1163 VFVGNVVHVVSQLSDSLIMACGGLLPLLASATAP---NNDMEIVDPCQQQLPISVSAGFLMRFAR 1224

Human  1441 MVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLECRQRQRDRGNKSSHGSSKPQ 1505
            :||..|.||.::|||:|.||||.:||::||.||:...|.||:.|..|.:|.|.....::.:.|.|
 Worm  1225 LVDTFVLASGVSFSELEQEKNMPAGGVLRQSLRISATVTVRHILASRIQQPDTPRYETNSTKKNQ 1289

Human  1506 EVPQSVTATAASKTP--LENVPGNLSPIKDPDRLLQDVDINRLRAVVFRD-VDDSKQAQFLALAV 1567
            .:.:.|......::|  ||||          :||:||.||.|::.||:|| |::::|||||||:|
 Worm  1290 CIMEFVREALEKRSPDGLENV----------ERLVQDSDITRIKGVVYRDMVEENRQAQFLALSV 1344

Human  1568 VYFISVLMVSKYRDILEPQRETTRTGSQPGRNIRQEINSPTSTVVVIPSIPHPSLNHGFLAKLIP 1632
            :|.:||||||:|||||||                             ||.|.|            
 Worm  1345 IYLVSVLMVSRYRDILEP-----------------------------PSSPSP------------ 1368

Human  1633 EQSFGHSFYKETPAAFPDTIKEKETPTPGEDIQVESSIPHTDSG---IGEEQVASILNGAELETS 1694
                          .|..|.:::|.   .|::..|:|..:..:|   .|.:.: ||.||.|   |
 Worm  1369 --------------FFDSTTQKQEN---SENVNSETSPENGSNGKLANGGDNL-SIKNGIE---S 1412

Human  1695 TGPDAMSELLSTLSSEVKKSQESLTENPSETLKPATSISSISQTKGINVKEILKSLVAAPVEIAE 1759
            .|.|...|                 ||..|             .:|.:...|      |.:::|.
 Worm  1413 NGNDGEEE-----------------ENGEE-------------GQGDDGGRI------AAIKVAN 1441

Human  1760 CGPEPIPYPDPALKRETQAILPMQFHSFDRSVVVPVKKPPPGSLAVTTVGATTAGSGLPTGSTSN 1824
            ..          :||..                                     |:.......|.
 Worm  1442 AD----------MKRGD-------------------------------------GNEYDEEELSK 1459

Human  1825 IFAATGATPKSMINTTGAVDSGSSSSSSSSSFVNGATSKNLPAVQTVAPMPEDSAENMSITAKLE 1889
            :..:.|..|.:|:                                   |:.:.:.....:|.||:
 Worm  1460 MHQSNGRRPSTMM-----------------------------------PVQQTAERRAYLTTKLQ 1489

Human  1890 RALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLV---CMKSSTSVVELVMLLCSQEWQNS 1951
            .|||..||||||:..||..:|.:||||:||||::.:..|   ....:.||:||||||||||||.|
 Worm  1490 TALETCAPLLREMMSDFRGYLQKTLLGTHGQEIMNDTKVLETLRNRNASVIELVMLLCSQEWQTS 1554

Human  1952 IQKNAGLAFIELINEGRLLCHAMKDHIVRVANEAEFILNRQRAEDVHKHAEFESQCAQYAADRRE 2016
            :||:||||||||:|||||:.||.:||::||||||:|||||.|||||.|||:||::..:..|.|.|
 Worm  1555 LQKHAGLAFIELVNEGRLMAHATRDHVLRVANEADFILNRLRAEDVSKHAQFEAESREQLAARHE 1619

Human  2017 EEKMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGAVSHSQLHDFWRLDYWEDDLRRRRRF 2081
            |...||.||::.:.||.:.|.:|.:|:..||:::..:....      .||:||.||||.|||:||
 Worm  1620 EYGRCDLLIASGRLRDSINATRLLEKMSAILSDQDDSKSGT------QFWKLDVWEDDSRRRKRF 1678

Human  2082 VRNAFGSTHAEALLKAAIEYGTEEDV---VKSKKTFRSQAIVNQNAETELMLEGDDDAVSLLQEK 2143
            |.||:||.|.||.|... |...|.::   .|.:|..:......||:.....|..:.|.....||.
 Worm  1679 VPNAYGSRHEEANLPEG-EKNEEPEISEQEKIRKVLKGLFSKRQNSSGSHELVDESDIDKWAQEV 1742

Human  2144 EIDNLAGPVVLSTPAQLIAPVVVAKGTLSITTTEIYFEVDEDDSAFKKIDTKVLAYTEGLHGKWM 2208
            :....:.....||.|:||||.||..||||:|..:::|:.:|.|..:||...:||.|.|.||.:|.
 Worm  1743 DPTPSSQSACFSTTAKLIAPGVVVPGTLSVTANDLFFDANESDPNYKKQCAQVLRYCEALHARWN 1807

Human  2209 FSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVVYSLPRVGVGTSYGLPQARRISL 2273
            ..||||:|.|||||||||||:|:|:||::||.|..:..||||||.|||||||..|||||:|:.||
 Worm  1808 LQEIRAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVKKVVYQLPRVGVGVKYGLPQSRKTSL 1872

Human  2274 ATPRQLYKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPG 2338
            .|||||:|.|:|..:||:||||||:|||||||:||||:|||:|||||||:||||.|:.|||::..
 Worm  1873 MTPRQLFKHSDMCAKWQKREISNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVAS 1937

Human  2339 NFRDLSKPIGALNPKRAVFYAERYETWEDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLNAN 2403
            ||||||||||||:..|..|:.:||.:|:|||.|.:||.|||||...||:||:|:|||.:.|:|.:
 Worm  1938 NFRDLSKPIGALSEARRKFFNDRYTSWDDDQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLH 2002

Human  2404 DGKFDHPDRTFSSVARSWRTSQRDTSDVKELIPEFYYLPEMFVNSNGYNLGVREDEVVVNDVDLP 2468
            |||||||||...|:..||...|||:.||||||||.:||||||.||:.:|||.|.|...|:||.||
 Worm  2003 DGKFDHPDRITHSIKDSWDRCQRDSHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLP 2067

Human  2469 PWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSIT 2533
            |||:.||.||.::|.||||:.|||||:|||||||||||||.|||||.|||::|||||:|.     
 Worm  2068 PWAESPEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVT----- 2127

Human  2534 DPVLREIPEAYFIRDPHTFLLTKDFIKAMEAQIQNFGQTPSQLLIEPHPPRSSAMHLCFLPQSPL 2598
             |.:.|.|..               :.|:|.||.:|||||||||.|.||||.|.|.:     :|.
 Worm  2128 -PKMAETPGQ---------------VAAIEQQILSFGQTPSQLLTEAHPPRHSIMSM-----APT 2171

Human  2599 MFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVTVTCSRLFAVNRWHN--TVGLRGAPG 2661
            ||: :..:|:.|::|:.|||||.::||||...|..|.||.|..:.:|::|:|.|  :.|......
 Worm  2172 MFR-RHDEDLCMMMKYISNSPVVYLAANTFHQLPQPTVVGVAQNLVFSLNKWDNSYSYGASQRSA 2235

Human  2662 YSLDQAH-----HLPIEMDPLI---ANNSGVNKRQITDLVDQSIQINAHCFVVTADNRYILICGF 2718
            .|:|.::     .||:..|..:   |:.:.|.:|.:.|..||.:.:....||.|.|:::|..||:
 Worm  2236 LSMDPSNAEGQVSLPLTADAQLASAASTTPVARRHLGDAFDQRLTVQCSNFVTTTDSKFIFACGY 2300

Human  2719 WDKSFRVYSTETGKLTQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLWYWSG-RHHIIG 2782
            .|.|||:..|::|::.|.|:||.|||||:||||:.:..|||:|:||.|.|::||:|:| ...|.|
 Worm  2301 PDYSFRIVDTDSGRVRQAVYGHGDVVTCIARSETSLFSDCYVVTGSMDCTVVLWHWNGTTGFIAG 2365

Human  2783 DNPNSSDYPAPRAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFP 2847
            :.....:.|:||::||||:..:..:.|.||.|||:||.::|..|:||.:.||||.:.|  :.:..
 Worm  2366 EYNQPGEVPSPRSILTGHEASISALCVSAEHGLVVSGCEDGVILIHTTSSDLLRRIRG--HGIVT 2428

Human  2848 RLISVSSEGHCII--YYERGRFSNFSINGKLLAQMEINDSTRAILLSSDGQNLVTGGDNGVVEVW 2910
            :| |:|.|  ||:  .::..|...:|...|.|.::.::|....:.::.||:..|||..||.:.:|
 Worm  2429 QL-SMSRE--CILLSLFDSKRMVTYSATAKKLDEVLVDDKIECVTVTRDGEFAVTGAVNGRINIW 2490

Human  2911 QACDFKQLYIYPGCDAGIRAMDLSHDQRTLITGMASGSIVAFNIDFNRWHYEHQNRY 2967
            :.....:||.|...::.:|::.:....|.::.|:.||:||.||.||||||||:::||
 Worm  2491 RMFPLTKLYTYQPLNSAVRSVAVVASHRFILGGLDSGAIVVFNADFNRWHYEYKHRY 2547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NBEANP_001371941.1 Laminin_G_3 255..402 CDD:463865 70/146 (48%)
DUF4704 467..947 CDD:464870 210/493 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..995 0/23 (0%)
WD 1. /evidence=ECO:0000305 1326..1368 17/41 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1490..1531 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1651..1675 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1711..1731 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1841..1860 0/18 (0%)
DUF1088 1966..2132 CDD:461925 73/168 (43%)
PH_BEACH 2158..2255 CDD:434260 53/96 (55%)
Beach 2287..2584 CDD:460459 179/296 (60%)
NBCH_WD40 2684..2956 CDD:466575 100/274 (36%)
WD 2. /evidence=ECO:0000305 2739..2782 24/43 (56%)
WD40 repeat 2745..2799 CDD:293791 24/54 (44%)
WD 3. /evidence=ECO:0000305 2799..2839 18/39 (46%)
WD40 repeat 2804..2839 CDD:293791 16/34 (47%)
WD40 repeat 2844..2873 CDD:293791 8/30 (27%)
WD 4. /evidence=ECO:0000305 2881..2920 10/38 (26%)
WD40 repeat 2882..2920 CDD:293791 10/37 (27%)
WD 5. /evidence=ECO:0000305 2923..2962 15/38 (39%)
WD40 repeat 2928..2954 CDD:293791 8/25 (32%)
sel-2NP_001379017.1 Laminin_G_3 384..530 CDD:463865 70/145 (48%)
DUF4704 595..1080 CDD:464870 209/492 (42%)
DUF1088 1569..1733 CDD:461925 73/170 (43%)
PH_BEACH 1757..1854 CDD:434260 53/96 (55%)
Beach 1887..2162 CDD:460459 179/295 (61%)
NBCH_WD40 2187..2532 CDD:466575 123/349 (35%)
WD40 repeat 2283..2321 CDD:293791 15/37 (41%)
WD40 repeat 2327..2382 CDD:293791 24/54 (44%)
WD40 repeat 2387..2422 CDD:293791 16/34 (47%)
WD40 repeat 2430..2462 CDD:293791 10/34 (29%)
WD40 repeat 2466..2502 CDD:293791 10/35 (29%)

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