DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vcp and TER94

DIOPT Version :9

Sequence 1:	NP_033529.3	Gene:	Vcp / 269523	MGIID:	99919	Length:	806	Species:	Mus musculus
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	664/800 - (83%)
Similarity:	736/800 - (92%)	Gaps:	6/800 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 KGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVL 72
            |.:||:|||||:|:|||||||:||.|:|||||||||.|||||||||||||:||||:|:|.|||||
  Fly    30 KREDLATAILKRKDRPNRLIVEEAQNDDNSVVSLSQAKMDELQLFRGDTVILKGKRRKETVCIVL 94

Mouse    73 SDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKP 137
            |||||.||||||||||||||.|.|.||:|:|.|||||||||:.:||||::.||:||||||:||||
  Fly    95 SDDTCPDEKIRMNRVVRNNLCVHLSDVVSVQSCPDVKYGKRVRILPIDESTEGVTGNLFEIYLKP 159

Mouse   138 YFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVG 202
            |||||||||..||.|:||..||.:|||||.|||.|||||||:|||.|:|:|||||:||||||.||
  Fly   160 YFLEAYRPIHMGDNFIVRAAMRPIEFKVVLTDPEPYCIVAPETVIFCDGDPIKREEEEESLNAVG 224

Mouse   203 YDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFF 267
            |||||||||||||||||||||||||:||||||||||||||:||||||||||||||||||||||||
  Fly   225 YDDIGGCRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGTGKTLIARAVANETGAFFF 289

Mouse   268 LINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLM 332
            |||||||||||||||||||||||||||||:||||||||:|||||||:||||||||||||||||||
  Fly   290 LINGPEIMSKLAGESESNLRKAFEEAEKNSPAIIFIDEIDAIAPKRDKTHGEVERRIVSQLLTLM 354

Mouse   333 DGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLE 397
            ||:|:.:|:|||||||||||||||||||||||||:||||||||||||:|:||||||||.||||||
  Fly   355 DGMKKSSHLIVMAATNRPNSIDPALRRFGRFDREIDIGIPDATGRLEVLRIHTKNMKLHDDVDLE 419

Mouse   398 QVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPS 462
            |:|.|:|||||||||:||||||||.||:|||||||||:.|||||:.||||||::||:|:::|:||
  Fly   420 QIAAESHGHVGADLASLCSEAALQQIREKMDLIDLEDDKIDAEVLASLAVTMENFRYAMTKSSPS 484

Mouse   463 ALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLL 527
            ||||||||||..||.||||||.||:|||||||||||||||||||||.||:|||||||||||||||
  Fly   485 ALRETVVEVPNTTWTDIGGLESVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLL 549

Mouse   528 AKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGD 592
            ||||||||||||||:||||||||||||||||||:||||||.|||||||||||||||||||||:||
  Fly   550 AKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARSAAPCVLFFDELDSIAKARGGNVGD 614

Mouse   593 GGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAIL 657
            .||||||||||||||||||..||||||||||||||||||||||||||||||||||||:|||.|||
  Fly   615 AGGAADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDDKSREAIL 679

Mouse   658 KANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNP-SAME 721
            ||||||||:||:|||.::||:|.||||||||||||||||||||::||:|||||:||..|. |||:
  Fly   680 KANLRKSPLAKEVDLTYIAKVTQGFSGADLTEICQRACKLAIRQAIEAEIRREKERAENQNSAMD 744

Mouse   722 VEEDDPVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFG-SFRFPSGNQGGAGPSQ 785
            ::||||||||...||||||:|||||||||||||||||||||||||||| :||||    |..|.:.
  Fly   745 MDEDDPVPEITSAHFEEAMKFARRSVSDNDIRKYEMFAQTLQQSRGFGQNFRFP----GQTGNTS 805

Mouse   786 GSGGGTGGSVYTEDNDDDLY 805
            |||.....:...::.|||||
  Fly   806 GSGNNLPVNSPGDNGDDDLY 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vcp	NP_033529.3	CDC48	25..764	CDD:273521	631/739 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727		11/19 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806		15/38 (39%)
		Interaction with UBXN6. /evidence=ECO:0000250	797..806		4/8 (50%)
		PIM motif. /evidence=ECO:0000250\|UniProtKB:P55072	802..806		3/3 (100%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	631/739 (85%)
		CDC48_N	47..129	CDD:280513	66/81 (81%)
		CDC48_2	153..213	CDD:215011	44/59 (75%)
		AAA	263..392	CDD:278434	118/128 (92%)
		AAA	536..669	CDD:278434	125/132 (95%)
		Vps4_C	<741..783	CDD:286426	34/41 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850195
Domainoid	1	1.000	263	1.000	Domainoid score	I1921
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5168
Inparanoid	1	1.050	1334	1.000	Inparanoid score	I145
Isobase	1	0.950	-	0	Normalized mean entropy	S74
OMA	1	1.010	-	-		QHG60945
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	1	1.000	-	-		oto94426
orthoMCL	1	0.900	-	-		OOG6_100525
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R182
SonicParanoid	1	1.000	-	-		X1760
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750