Protein Alignment Zw10 and Zw10

DIOPT Version :9

• Sequence 1: NP_036169.1
• Gene: Zw10 / 26951
• MGIID: 1349478
• Length: 779
• Species: Mus musculus
• Sequence 2: NP_524901.2
• Gene: Zw10 / 47874
• FlyBaseID: FBgn0004643
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 825
• Identity: 184/825 - (22%)
• Similarity: 325/825 - (39%)
• Gaps: 182/825 - (22%)

Mouse    12 SGSLEKEDLGTRISRLTRRVEEIKGEVCNMISKKYSEFLPTMQSAQALVTQVDTLSNDIDQLKSR 76
            :|....|...:.|.::..||...:..|...|...|:||||...|....:.:..:|:.:|..:...
  Fly    20 NGCANVEATQSAILKVLTRVNRFQMRVRKHIEDNYTEFLPNNTSPDIFLEESGSLNREIHDMLEN 84

Mouse    77 IETEVCRDLHISTVEFTNLKQQLERDSVVLTL-----LKQLQEFSSAIEEYNSALAEKKYI---- 132
            :.:|....|..:.|:.....:||.  .::|.|     :.::.|....:||   |.|.|.|:
  Fly    85 LGSEGLDALDEANVKMAGNGRQLR--EILLGLGVSEHVLRIDELFQCVEE---AKATKDYLVLLD 144

Mouse   133 -----------------------PAARHLEEAQECLKLLKSRKCFDLKMLKSLSMELTVQKQNIL 174
                                   |..|.:.:|.||.:.:|              ::..||...:.
  Fly   145 LVGRLRAFIYGDDSVDGDAQVATPEVRRIFKALECYETIK--------------VKYHVQAYMLQ 195

Mouse   175 YHLGEDWQKLVVWK---FPPAKDTSSLESCLQTELHLCTEQPEKEDMTPLPSISSVLLAFSILGE 236
            ..|.|.:.:||..:   ||.::               |.......|.|.|..|...|.      :
  Fly   196 QSLQERFDRLVQLQCKSFPTSR---------------CVTLQVSRDQTQLQDIVQALF------Q 239

Mouse   237 LPTKLKSFGQMLLKYILKPLVTCPSLHAVIE----------------RQPSSVSICFESLTTDLE 285
            .|.......:.||...::|::..|.:....|                ::|||..:
  Fly   240 EPYNPARLCEFLLDNCIEPVIMRPVMADYSEEADGGTYVRLSLSYATKEPSSAQL---------- 294

Mouse   286 HPSPPEAFAKIRLVLEVLQKQLLDLPLDADLEIGKVPGIVLAEMLGEGIWEDLSECLIRNCLVYS 350
            .|:..:....:||:|..|..  ::..:..|..   |.||:     |:.:.:.:.:.|:..||:.:
  Fly   295 RPNYKQVLENLRLLLHTLAG--INCSVSRDQH---VFGII-----GDHVKDKMLKLLVDECLIPA 349

Mouse   351 IPTNSSKLQEYE--EIIQSTEEFEKFLKEMRFLKGDTTDLL-KYARNINSHFANKKCQDVIVAAR 412
            :|.::   :||:  .:.:...:.|:.|.:...:..:....| ::.....:::.|:..:.|:..||
  Fly   350 VPEST---EEYQTSTLCEDVAQLEQLLVDSFIINPEQDRALGQFVEKYETYYRNRMYRRVLETAR 411

Mouse   413 NLMTSEIHNTVKIGPDCKEALPDLPSPDADHKLQVQTVCKAQFTDAGNLEPETSLDPQSFSLPTC 477
            .::..::.:.|.:.|:                               |...|.:.||  |..|.|
  Fly   412 EIIQRDLQDMVLVAPN-------------------------------NHSAEVANDP--FLFPRC 443

Mouse   478 RISEAVKKLMELAYQTLLEATTS-SDQCAVQLFYSVRNIFHLFHDVVPTYHKENLRKLPQLAAIH 541
            .||::.:..::|..:.|.:.|.. .||.|..:...:..:.|.:.:.||..|::.|..:||.|.:.
  Fly   444 MISKSAQDFVKLMDRILRQPTDKLGDQEADPIAGVISIMLHTYINEVPKVHRKLLESIPQQAVLF 508

Mouse   542 HNNCMYIAHHLLTLGHQFRLRLAPILCDGTTTFVDLVPGFRRLGTECFLAQMQAQKGELLERLSS 606
            |||||:..|.:....::           |..:...|....:..|.:.|..|:..|...|:..:.
  Fly   509 HNNCMFFTHWVAQHANK-----------GIESLAALAKTLQATGQQHFRVQVDYQSSILMGIMQ- 561

Mouse   607 ARSFANMDDEENYSAAS---KAVRQVLHQLRRLGIVWQDVLPVNIYCKAMGTLLNTAIAEMMSRI 668
                 ..:.|..::..|   |.|||.|.||..|..||.:|||..:|......|:||.:||::.|:
  Fly   562 -----EFEFESTHTLGSGPLKLVRQCLRQLELLKNVWANVLPETVYNATFCELINTFVAELIRRV 621

Mouse   669 TALEDISTEDGDRLYSLCKTVMDEGPQVFAPLSDENKNKKYQEEVPVYVSKWMPFKELMIMLQAS 733
            ..|.|||.:....|..|...|:...|.:|          :...|| |.|..|:..::|..||.||
  Fly   622 FTLRDISAQMACELSDLIDVVLQRAPTLF----------REPNEV-VQVLSWLKLQQLKAMLNAS 675

Mouse   734 LQEIGDRWADGKGPLATAFPSSEVKALIRALFQNTERRAAALAKI 778
            |.||.:.|.||.|||..::.|.|:|.|||||||:|:.||.|:.:|
  Fly   676 LMEITELWGDGVGPLTASYKSDEIKHLIRALFQDTDWRAKAITQI 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zw10	NP_036169.1	Interaction with RINT1. /evidence=ECO:0000250|UniProtKB:O43264	2..317		64/355 (18%)
		Interaction with ZWINT. /evidence=ECO:0000250|UniProtKB:O43264	2..81		15/68 (22%)
		Zw10	9..621	CDD:283827	120/663 (18%)
		PKc_like	<598..>768	CDD:304357	61/172 (35%)
Zw10	NP_524901.2	Zw10	20..574	CDD:283827	112/608 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841926
Domainoid	1	1.000	108	1.000	Domainoid score	I6469
eggNOG	1	0.900	-	-		E1_KOG2163
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4102
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55465
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006350
OrthoInspector	1	1.000	-	-		oto94930
orthoMCL	1	0.900	-	-		OOG6_104989
Panther	1	1.100	-	-	LDO	PTHR12205
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3777
SonicParanoid	1	1.000	-	-		X6070
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790