Protein Alignment Mprip and osp

DIOPT Version :9

• Sequence 1: NP_001355860.1
• Gene: Mprip / 26936
• MGIID: 1349438
• Length: 2423
• Species: Mus musculus
• Sequence 2: NP_001162975.1
• Gene: osp / 34850
• FlyBaseID: FBgn0003016
• Length: 1566
• Species: Drosophila melanogaster
• Alignment Length: 1691
• Identity: 364/1691 - (21%)
• Similarity: 659/1691 - (38%)
• Gaps: 450/1691 - (26%)

Mouse     4 AKENPCRKFQANIFNKSKCQNCFKPRESHLL-----------NDEDLTQAKPIYGGWLLLAPDGT 57
            |:...||||..||||||||.:||:.||.|..           |..:....|....|:|.:||| .
  Fly    34 ARTADCRKFTPNIFNKSKCSHCFRQREEHSAAALECNRRTSSNLAEPASRKVSKCGYLFVAPD-W 97

Mouse    58 DFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQCTDVVDGEARTGQKFSLCIL 122
            ||.||::|:::||||:|:||:.|.|.|::|:.|.|:||..::|.:..:|......||...|:.|.
  Fly    98 DFSNPLYRTKRWQRRWFVLYDDGELTYSVDDYPETIPQACVDMTKVLEVTSAVEVTGHPNSIAIT 162

Mouse   123 TPDKEHFIRAETKEIISGWLEMLMVYPRTNKQNQKKKRKVEPPTPQEPGPAKMAVTSSSGGSSGS 187
            .|::..|::..:.|....||.:|..:|   |...:.||....|..|..|    ::..:|.|....
  Fly   163 APERVTFVKGTSSEESQWWLNILAAFP---KSKGRHKRSATLPGGQVVG----SLRPTSNGDLTL 220

Mouse   188 SSSIPSAEKVPTTKSTLWQEEMRAKDQPDGTSLSPAQ-SPSQSQPPAACTPREPGLESKEDESTI 251
            |:.:.:       :.:.:.::.....|..|..||... .||.:        :..|......:|.:
  Fly   221 STKLGN-------RHSSYHKDTLTSSQSAGNLLSSLDLGPSST--------KTAGSPLTTTQSAL 270

Mouse   252 SGDRVDGGRKVRVESGYFSLEKAKQDLRAEEQLPPLLSPPSPSTPHSRYGCPGSPSQELSHPLHS 316
            :.|..|.|    ||:|    |...:|...|..:|......|...........|:   |:::.:..
  Fly   271 ADDEEDDG----VETG----EDVDEDEEDETSVPRKSKTVSMGGQDENNRNAGN---EITNRVSQ 324

Mouse   317 PGLPAPSRMVYSIC---------PASLGEASRSPNHMDSSSAGGWGTEI---LGSTFAFKASRQY 369
            |          :.|         ..::.:.:.:..::.......|.|.:   |.:...|....||
  Fly   325 P----------TTCLLIEDIRRDEKTIKDIANTITNLSQQQNKRWSTAVNNALNNQHHFGHHSQY 379

Mouse   370 AALADVPKAIRISHREAFQVERRRLEHRTRARSPG--REEVARLFGNERRR--SQVIEKFEALDI 430
                      :::.|:....:.......|::::|.  |.:...|..|....  |.:::|...: :
  Fly   380 ----------QVTSRDETDFQMSSNSSSTKSQNPASERPKSLPLASNSTPAIVSAIVKKIPTV-M 433

Mouse   431 EKAEHMETN---MLILTTPSSDTRQGRSERRAIPRKRDFASEAPTAPLSDACP--LSPHRRAKSL 490
            |:.:..:..   .|.|.:|    :..:.||         ........|.:.|.  ::.....:|:
  Fly   434 EQGDKTKPTARLQLHLKSP----KHYQHER---------GDPDGGCNLDELCVNYMAKTDELRSV 485

Mouse   491 DRRSTESS-------MTPDLLNFKKGWLTKQYEDG---QWKKHWFVLADQSLRYYRDSVAEEAAD 545
            .:.:::||       :..:.||.|||||.||  |.   :|.||||.|:..:|.||||.:.||...
  Fly   486 GKANSKSSSGQGKPPVKEESLNAKKGWLMKQ--DNRTCEWSKHWFTLSGAALFYYRDPLCEERGV 548

Mouse   546 LDGEINLSTCYDVTEYP-VQRNYGFQIHTKEGE-FTLSAMTSGIRRNWI---------------- 592
            |||.:::::...|...| ..:.:.||:.|.:.: ..|::::...|.:|:
  Fly   549 LDGVLDVNSLTSVIPEPAASKQHAFQLTTWDKQRLVLASLSPSSRNSWLAVLRSAAGLPQLDTPP 613

Mouse   593 ------QTIMKHVL--PASAPDVTSSLPEGKNKSTSFETCSRSTEKQEAEPGEPDPEQKKSRARE 649
                  |..:|..|  |:|:| ||...|.|.:.|:       ..|.:.|..|
  Fly   614 KQTDIEQDFIKAQLQQPSSSP-VTPGTPAGPHFSS-------DEEYRTASEG------------- 657

Mouse   650 RRREGRSKTFDWAEFRPIQQALAQERASAVGSSDSGDP----GCLEAEPGELERERARRREERRK 710
                ||..:.||                  ||..|..|    .||.........:|:|......:
  Fly   658 ----GRRDSLDW------------------GSPLSPSPPVLRSCLRNRSLASLHKRSRSSPPSSR 700

Mouse   711 RFGMLDTIDGPGMEDTALRMDIDRSPGLLGTPDLKTQNVHVEIEQRWHQVETTPLREE---KQVP 772
            |    .|:|....::..          ||..|:........|::|   |.||  ||.|   ::..
  Fly   701 R----STVDSVASDELP----------LLVVPEEMQPTESRELKQ---QCET--LRAEASLREAR 746

Mouse   773 IAPLHLSLEDRSERLST--HELTSLLEKELEQSQKEASDLLE-----------QNRLLQDQLRVA 824
            ::.|..:|:...::|:.  .|....|..||.|:::.||||:.           |.:.|:|  |:|
  Fly   747 MSELLATLQRTEQQLTARLQEQQQQLNSELTQAKQSASDLMHNLGMQLTESQCQIKQLED--RLA 809

Mouse   825 LGREQSAREGYV--LQTEVATSPSGA-----WQRLHRVNQ-----DLQ--SELEAQCRRQELITQ 875
            .|.|::  ||..  |:...|...||.     .|| |::.:     ||.  |:::..|.:::.:.:
  Fly   810 QGIEEN--EGLYKRLRELQAQDHSGGAALSNLQR-HKIKRMDSLSDLTTISDIDPYCLQRDSLAE 871

Mouse   876 QIQTLKHSYGEAKDAIRHHEAEIQTLQTRLGNAAAELAIKEQALAKLKGE----LKMEQGKVREQ 936
            :...|:..:.:|.:.||..:.|::..|.:........|..:|.|.:.:.|    |::...::::.
  Fly   872 EYNELRSRFEKAVNEIRAMKRELKQSQNQYDALELAQAALQQKLERRQHEDGAQLQLMAARIQDL 936

Mouse   937 LEEWQHSKAMLSGQLRASEQKLRSTEAR--LLEKTQELRDLETQQALQRD--RQKE--------- 988
            ..::..|:.    |:||.:|||..:|.|  |..|.:|..:|:..: |||:  .:||
  Fly   937 TLKYSSSER----QVRALKQKLAKSERRRSLSLKGKEQLELKLSE-LQRETVERKEGTPPESSSS 996

Mouse   989 --------------------------VQRLQECIAELSQQLGTSEQAQR----LMEKK--LKRNY 1021
                                      .:||::.:.:| ||:...::.:|    :.::|  |::..
  Fly   997 ESSSQSPLNAHLLQRLHSLEHVLLGSKERLEQSLTQL-QQIRAGQRTRRSVSPMNDRKDGLRQLE 1060

Mouse  1022 TLLLESC----EQEKQALLQNLKEVEDKASAYE-DQLQGHVQQVEALQKEKLSETCKGSEQVHKL 1081
            ..|.|:|    ||.:...||:        |.:: ..|:..|:::.|||::  :||     .:.:.
  Fly  1061 RALAETCVMVSEQMELTCLQD--------SCHKCCDLRQRVEKLSALQQQ--TET-----DLQRS 1110

Mouse  1082 EEELEAREASIRQLAQHVQSLHDERDLIKHQFQELMERVATSDGDVAELQEKL------RGKEVD 1140
            |:.||.||..:.|..:...|...|::|:..|.|||.|.:.........|:::|      .||:::
  Fly  1111 EQLLEQRETDLAQALEKCASQEQEQELLLQQRQELSEELGRQQERCRRLEKRLELLEREHGKQLE 1175

Mouse  1141 -YQNLEHSHH-----------RVSVQLQSVRTLLREKEEELKHIKETHERV---LEKKDQDLNEA 1190
             .:.:.|:.|           |...:::.:|||.   |:.|..::.:|:|:   ||:|.:...|.
  Fly  1176 CLREVYHTEHANAADEQSFRKRYQTEIEQLRTLC---EKGLSAMETSHKRLTMDLEQKHKMEIER 1237

Mouse  1191 LV--KMIALGSSLEETEIKLQEKEECLRRFVSDSPKDA----KEPLSTTEPTEE--GSGILPLGS 1247
            |:  |..||.   |||:..|...:...:...|:..::.    :|.|...:..|:  |.|
  Fly  1238 LLAEKETALA---EETQATLAALDAMRKAHQSEVQREVARFKQEFLRQVQRGEQMRGDG------ 1293

Mouse  1248 VTRVFPGFPHSQPEDEDPSAGLGE-------EGSSGSLSREENTILPK----------------- 1288
                      ::.::||    |||       .....|:...||..|.:
  Fly  1294 ----------AKLKEED----LGELRMEILAFSEKYSIKCVENAALEEKLHMANSKLRHFQQMQQ 1344

Mouse  1289 ------------SADMPEREGH----LQSTSKSDPGAPIKRPRIRFSTIQCQRYIHPEGCAKAWT 1337
                        ::|.|..:.|    |.|.::.|.......|..:.......|       ..|.|
  Fly  1345 LELRNKQFRAHLASDDPSNDVHFVQGLTSDAREDADCEDSEPAPQILGATATR-------TTATT 1402

Mouse  1338 SSTSSDTSQDQSPSEDSVSSEATPNTLPAAADAETYISIIHSLETKLYV-TEEKLKDVTVRLESQ 1401
            ::|::.|:...:|||    :|:.|::....||:..  :....:|..|:| ....|....|...:.
  Fly  1403 TTTATATTTSAAPSE----TESNPDSDRETADSSR--APPEKMEQSLFVIPSHMLNSSLVPAANA 1461

Mouse  1402 QGQSQEA---------------------LLALHQ-----QWAGTEAQLREQLRASLLQASALASQ 1440
            ..|||.:                     :.|::|     |.....:...:.||.|..|.|..:|:
  Fly  1462 SDQSQRSQLYRDLDGPEDGYEPCYRPFDIFAIYQNRLSYQGLKGSSTFGKSLRKSAAQTSPASSE 1526

Mouse  1441 L 1441
            :
  Fly  1527 I 1527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mprip	NP_001355860.1	PH_RIP	16..151	CDD:269942	52/145 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	152..262		20/110 (18%)
		PH_M-RIP	507..608	CDD:270094	38/129 (29%)
		SMC_prok_A	<751..>996	CDD:274009	71/317 (22%)
		sbcc	<895..>1576	CDD:129705	139/697 (20%)
		Smc	<895..1214	CDD:224117	88/395 (22%)
		SMC_prok_A	1886..>2240	CDD:274009
		PRK03918	2133..>2400	CDD:235175
osp	NP_001162975.1	PH_RIP	48..191	CDD:269942	50/146 (34%)
		PH	85..185	CDD:278594	36/100 (36%)
		PH_M-RIP	509..613	CDD:270094	32/105 (30%)
		PH	509..603	CDD:278594	32/95 (34%)
		SbcC	726..1353	CDD:223496	147/683 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834683
Domainoid	1	1.000	83	1.000	Domainoid score	I8362
eggNOG	1	0.900	-	-		E1_KOG4807
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3394
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002350
OrthoInspector	1	1.000	-	-		otm44067
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR17271
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3300
SonicParanoid	1	1.000	-	-		X3426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.970