Protein Alignment GHSR and PK2-R2

DIOPT Version :10

• Sequence 1: NP_940799.1
• Gene: GHSR / 2693
• HGNCID: 4267
• Length: 366
• Species: Homo sapiens
• Sequence 2: NP_731788.1
• Gene: PK2-R2 / 41638
• FlyBaseID: FBgn0038139
• Length: 599
• Species: Drosophila melanogaster
• Alignment Length: 369
• Identity: 134/369 - (36%)
• Similarity: 175/369 - (47%)
• Gaps: 54/369 - (14%)

Human    32 DELL----QLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLI 92
            :|||    .:.|..|||.::.....:|:.|:.|||:|.:|:||...:.|.||.||.::|.|| :|
  Fly    51 EELLPTVTPMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISD-MI 114

Human    93 FLC--MPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVV 155
            .||  ||.||..||....:.|.|.:|.|...:||:...||||||||.:||||.|||.|.|...:.
  Fly   115 LLCSGMPQDLYNLWHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMS 179

Human   156 TKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHEN-GTDPWDTNECRPTEFAVRSGLLTVMVWVSSI 219
            ...|....||.||..|...|.|..:...|..:. ||.....|:.....||| ||.|
  Fly   180 KLSRAVKFIFAIWIAALLLALPQAIQFSVVMQGMGTSCTMKNDFFAHVFAV-SGFL--------- 234

Human   220 FFFLPVFCLTVLYSLIGRKLWR--------RRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCW 276
            ||..|:..:.|||.|||.||.|        ||..|...|.|.:    .:.::||..|..||.:||
  Fly   235 FFGGPMTAICVLYVLIGVKLKRSRLLQALPRRCYDVNRGISAQ----TRVIRMLVAVAVAFFICW 295

Human   277 LPFHVGRYLFSKSFEPGSLEIAQISQYCNLV-------SFVLFYLSAAINPILYNIMSKKYR--- 331
            .|||..| |.:.......:|    ||:.|.|       |.||::||..|||:||||||.|:|
  Fly   296 APFHAQR-LMAVYGSTSGIE----SQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAF 355

Human   332 -VAVFRLLGFE--------PFSQRKLSTLKDESSRAWTESSINT 366
             |.:.|..|..        |.:...|...:..|.|..|..|:.|
  Fly   356 KVTLARHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRT 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GHSR	NP_940799.1	7tmA_GHSR	44..334	CDD:320259	119/311 (38%)
		TM helix 1	44..71	CDD:320259	9/26 (35%)
		TM helix 2	78..103	CDD:320259	14/26 (54%)
		TM helix 3	116..146	CDD:320259	17/29 (59%)
		TM helix 4	158..180	CDD:320259	8/21 (38%)
		TM helix 5	209..238	CDD:320259	10/28 (36%)
		TM helix 6	256..286	CDD:320259	11/29 (38%)
		TM helix 7	302..327	CDD:320259	15/31 (48%)
PK2-R2	NP_731788.1	7tmA_capaR	69..355	CDD:320262	117/305 (38%)
		TM helix 1	69..94	CDD:320262	8/24 (33%)
		TM helix 2	101..127	CDD:320262	14/26 (54%)
		TM helix 3	140..170	CDD:320262	17/29 (59%)
		TM helix 4	182..204	CDD:320262	8/21 (38%)
		TM helix 5	225..253	CDD:320262	15/37 (41%)
		TM helix 6	275..305	CDD:320262	13/34 (38%)
		TM helix 7	323..348	CDD:320262	12/24 (50%)