DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMHR2 and acvr2ba

DIOPT Version :9

Sequence 1:	XP_011536475.1	Gene:	AMHR2 / 269	HGNCID:	465	Length:	593	Species:	Homo sapiens
Sequence 2:	NP_571285.1	Gene:	acvr2ba / 30457	ZFINID:	ZDB-GENE-980526-549	Length:	509	Species:	Danio rerio

Alignment Length:	577	Identity:	171/577 - (29%)
Similarity:	250/577 - (43%)	Gaps:	135/577 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLGSLGLWALLPTAVEAPPNR-----RTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRC 60
            |..||...|||.....|.|:.     |.|:::                :...|:.:..|....||
Zfish     1 MFASLLTLALLLATFAADPSHGEVETRECLYY----------------NVNWEVEKTNRSGVERC 49

Human    61 ---------CFGIWNLTQDRAQVEMQGCRDSDEPGC----ESLHCDPSPRAHPSPGSTLFTCSCG 112
                     |:..|.......|:..:||. .|:..|    |.:..:.:|:        :|.|.|.
Zfish    50 EGEKDKRSHCYASWRNNSGSIQLVKKGCW-LDDFNCYDRQECVATEENPQ--------VFFCCCE 105

Human   113 TDFCNANYSHL---------PPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILA 168
            .:|||..::||         |||.||.                    ||.:.:..||.|..:.:|
Zfish   106 GNFCNERFTHLPDISGPVISPPPVSPS--------------------LLNVLVYSLLPLSMLSMA 150

Human   169 -LLQRKNYRVRGEPV--------PEPRPDSGRDWSVELQELPELCFSQQVIREGGHAVVWAGQLQ 224
             ||....||.|..|.        |.|.|.|.   .|.|:.|..|    :|...|....||..|:.
Zfish   151 VLLAFWMYRHRKPPYGHVDVNEDPGPSPPSP---LVGLKPLQLL----EVKARGRFGCVWKAQMI 208

Human   225 GKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKDCVC 289
            .:.||:|.||.:....:|.||.::..||::||:::|||.|.:.| ..|.....|:.|.|.:
Zfish   209 NEYVAVKIFPIQDKLSWQNEREMFSTPGMKHDNLLRFIAAEKRG-SNLEMEFWLITEFHER---- 268

Human   290 LCPRGRAPHNSLCPIGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEE--RWQNGQYKPGIAHR 352
                           |||..||......|.....:|.|:|.|||:|||:  |.:....||.||||
Zfish   269 ---------------GSLTDYLKGNAVSWADLCVIAESMACGLAYLHEDVPRSKGEGPKPAIAHR 318

Human   353 DLSSQNVLIREDGSCAIGDLGLALVL-PGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTL 416
            |..|:||:::.|.:..|||.|||:.. ||  :||..|..|         .||:||||||:|:..:
Zfish   319 DFKSKNVMLKMDLTAVIGDFGLAVRFEPG--KPPGDTHGQ---------VGTRRYMAPEVLEGAI 372

Human   417 DLQ-DWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQE 480
            :.| |   :..|.|:|::.|:|||::|||.  ..|.....:.|.:|.|:|..|:.::|....|.:
Zfish   373 NFQRD---SFLRIDMYAMGLVLWELVSRCK--AADGPVDEYMLPFEEEIGQHPSLEDLQDAVVHK 432

Human   481 RRRPYIPSTWRCFATDPDGL---RELLEDCWDADPEARLTAECVQQRLAALAHPQES 534
            :.||.....|    ....||   .|.:|:|||.|.||||:|.|||:|::.:.....|
Zfish   433 KLRPAFKDCW----LKHSGLCQMCETMEECWDHDAEARLSAGCVQERISQIRRVSSS 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMHR2	XP_011536475.1	Pkinase	208..531	CDD:278497	114/329 (35%)
AMHR2	XP_011536475.1	PKc_like	208..528	CDD:304357	114/326 (35%)
acvr2ba	NP_571285.1	Activin_recp	49..117	CDD:279413	17/76 (22%)
		S_TKc	189..469	CDD:214567	110/323 (34%)
		STKc_ACVR2b	192..482	CDD:271042	114/329 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920