DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMHR2 and Amhr2

DIOPT Version :9

Sequence 1:	XP_011536475.1	Gene:	AMHR2 / 269	HGNCID:	465	Length:	593	Species:	Homo sapiens
Sequence 2:	NP_112260.1	Gene:	Amhr2 / 29530	RGDID:	70964	Length:	557	Species:	Rattus norvegicus

Alignment Length:	583	Identity:	443/583 - (75%)
Similarity:	485/583 - (83%)	Gaps:	26/583 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIW 65
            |||:||||.|||.|.:..|||||||||||||||||||||||::|.|...|:.||||||.||||||
  Rat     1 MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEVVDAGPGPPKGIRCLYSHCCFGIW 65

Human    66 NLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPG 130
            |||..|||||||||.||||||||||||||.|||||||.||||||||||||||||||||||.|:.|
  Rat    66 NLTHGRAQVEMQGCLDSDEPGCESLHCDPVPRAHPSPSSTLFTCSCGTDFCNANYSHLPPSGNRG 130

Human   131 TPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSV 195
            .||.|.|||.||..||||.:|||:||:|||.:  |||||||||..||:|...|||.|.||.|.|.
  Rat   131 APGPQEPQATPGGPIWMAQLLLGVFLVLLLSI--IILALLQRKACRVQGGSDPEPEPGSGGDCSE 193

Human   196 ELQELPELCFSQQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVR 260
            ||.||.||.|| |||:||||||||||:|||::|||||||||:||||:||||:|:|.||||:||||
  Rat   194 ELPELAELRFS-QVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVR 257

Human   261 FITASRGGPGRLLSGPLLVLELHPKDCVCLCPRGRAPHNSLCPIGSLCHYLTQYTSDWGSSLRMA 325
            ||||.:||||.|.|||||||||:||                   |||||||||||||||||||||
  Rat   258 FITAGQGGPGPLPSGPLLVLELYPK-------------------GSLCHYLTQYTSDWGSSLRMA 303

Human   326 LSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPT 390
            ||||:||||||.||||:||||||||||||||||||||||.||||||||||||||||.||||..||
  Rat   304 LSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPT 368

Human   391 QPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPP 455
            ||:|||||:|||||||||||||||||||||||.||:|||:||||||||||||||.|||||..|||
  Rat   369 QPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPP 433

Human   456 FQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAEC 520
            ||||||||||:.|::.|||||||.||:||.|||:|.|.||||.||||||||||||||||||||||
  Rat   434 FQLAYEAELGSNPSACELWALAVAERKRPNIPSSWSCSATDPRGLRELLEDCWDADPEARLTAEC 498

Human   521 VQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRN 583
            |||||||||:||.:..||||||:|    |||:|.:.||....|||||:|:|..|||||..|::
  Rat   499 VQQRLAALAYPQVASSFPESCPQG----CPENCPAAPASAAFPCRPQQSSCLLSVQQGSGSKS 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMHR2	XP_011536475.1	Pkinase	208..531	CDD:278497	261/322 (81%)
AMHR2	XP_011536475.1	PKc_like	208..528	CDD:304357	258/319 (81%)
Amhr2	NP_112260.1	Activin_recp	<61..119	CDD:395845	52/57 (91%)
Amhr2	NP_112260.1	PKc_like	205..506	CDD:419665	258/319 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I6534
eggNOG	1	0.900	-	-		E2759_KOG3653
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10746
Inparanoid	1	1.050	910	1.000	Inparanoid score	I6289
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42011
OrthoDB	1	1.010	-	-		D147322at7742
OrthoFinder	1	1.000	-	-		FOG0013991
OrthoInspector	1	1.000	-	-		oto133649
orthoMCL	1	0.900	-	-		OOG6_131417
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X12986
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.340