Protein Alignment AMHR2 and daf-4

DIOPT Version :9

• Sequence 1: XP_011536475.1
• Gene: AMHR2 / 269
• HGNCID: 465
• Length: 593
• Species: Homo sapiens
• Sequence 2: NP_498211.1
• Gene: daf-4 / 175781
• WormBaseID: WBGene00000900
• Length: 744
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 150/640 - (23%)
• Similarity: 243/640 - (37%)
• Gaps: 189/640 - (29%)

Human    51 RAIRCLYSRCCFGI----WNLTQ-----DRAQVEMQGC---RDSDEPGCESLHCDPSPRAHPSPG 103
            :|:.||   ..||:    .|.|:     |:.|.:..||   :.:|...||:   :.|.|...|..
 Worm   118 KAVGCL---AVFGLPTQEINSTEPYLKVDKPQYKSLGCMPYQHADSMNCEN---ESSCRQGRSFR 176

Human   104 STLFTCSCGTDFCN-------ANYSHLPPPGSPGTPGSQGPQAAPGESI------WMALVLLGLF 155
            ..:..|.|.|:.||       .|.|......:.....:..|.....||:      |:.::.|.:.
 Worm   177 GGIGMCCCSTNNCNMPDLIEMVNPSLKKDSDNSALLWASTPSNMDLESLDKFPFYWIIIIALSVI 241

Human   156 L-LLLLLLGSIILALLQRKNYRVRGE------------------PVPEPRPDSGRDWSVELQELP 201
            | :.||:|..:.....|.|...::.:                  |:.||..:     .:|:.|.|
 Worm   242 LCIALLILAYVGWKFQQNKKEEIKKQQKIKFDMEKTDALEAGNVPLVEPEEE-----MIEMVETP 301

Human   202 -ELCFSQ-QVIREGGHAVVWAGQL-----QGKLVAIKAFPPRSVAQFQAERALY----ELPGLQH 255
             ||..:. |:|.:|....|:..|.     :.:|||:|.......|.|.||:.::    |.| ..:
 Worm   302 KELPITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYP-KWY 365

Human   256 DHIVRFITASRGGPGRLLSGPLLVLELHPKDCVCLCPRGRAPHNSLCPIGSLCHYLTQYTSDWGS 320
            ..||.|:.|.:.|     ....:|.|.|.:                   .||...|........|
 Worm   366 KSIVEFVCAEKIG-----DEYWIVTEFHER-------------------LSLYELLKNNVISITS 406

Human   321 SLRMALSLAQGLAFLHEER-WQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQP 384
            :.|:.:|:..||.|||::| :..|..|..|.|||:.|:|:|::.|.:..|.|.|||.:.
 Worm   407 ANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIY------ 465

Human   385 PAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRP 449
             ::...|..   .:.:.||:|||:||:|:...:...  .|.:..|:||:.|::||::|| ..|..
 Worm   466 -SYDIEQSD---LLGQVGTKRYMSPEMLEGATEFTP--TAFKAMDVYSMGLVMWEVISR-TKLHQ 523

Human   450 DSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDG---------LRELLE 505
            ...||.:|:.::. :|..||...:....|.::.||    .||      |.         |:::.|
 Worm   524 TDEPPNYQMPFQV-IGFDPTIGLMRNYVVSKKERP----QWR------DEIIKHEYMSLLKKVTE 577

Human   506 DCWDADPEARLTAECV-------------------------------------------QQRLAA 527
            :.||.:..||:||.|.                                           .|...|
 Worm   578 EMWDPEACARITAGCAFARVWNHIMSSPDSSEGYHSGSSMKNRGVDDVEQSEKPEGIEEMQHYHA 642

Human   528 LAHPQESHPFP----ESCPRGCPP------------LCPEDCTSIPAPTILPCRP 566
            .:..:..||.|    :|||   ||            |.|::..  |.|..||..|
 Worm   643 SSPSKRQHPSPNPFFDSCP---PPPPIPVILENGGILQPDNAE--PEPEELPDLP 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMHR2	XP_011536475.1	Pkinase	208..531	CDD:278497	92/384 (24%)
		PKc_like	208..528	CDD:304357	91/381 (24%)
daf-4	NP_498211.1	ET	<146..192	CDD:279950	14/48 (29%)
		PKc_like	310..603	CDD:304357	90/341 (26%)
		S_TKc	310..590	CDD:214567	87/328 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020