DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdhr2 and ds

DIOPT Version :9

Sequence 1:NP_001028536.2 Gene:Cdhr2 / 268663 MGIID:2687323 Length:1308 Species:Mus musculus
Sequence 2:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster


Alignment Length:1334 Identity:345/1334 - (25%)
Similarity:568/1334 - (42%) Gaps:232/1334 - (17%)


- Green bases have known domain annotations that are detailed below.


Mouse    11 LPAFM-VSVTA----NSPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSDNDH---LTYGIS---G 64
            |..|| |::|.    ::.|.|..:....|:||:..||.....:.|:|:|.|.   :.|.|:   .
  Fly   266 LRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQS 330

Mouse    65 PNASYFSVNANTGEVKLASPLDFETVPFFKITISTSD----GLNIRTAEMQVIVEDRNDNIP--- 122
            .....|.::..||.:.:...|||||....::.:...|    .|. .||.:.:.|.|.|||.|   
  Fly   331 DKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLE-TTAFVSIRVTDVNDNQPTIN 394

Mouse   123 -VFLNTEFSTSINETLPVGSVVFSVLAEDKDTGTAGLVQYFIEKV--------IPSTANSNNLFR 178
             :||:.:.|..|:|:...|..|..:...|.|:.|    :|....|        ...|...|:::.
  Fly   395 VIFLSDDASPKISESAQPGEFVARISVHDPDSKT----EYANVNVTLNGGDGHFALTTRDNSIYL 455

Mouse   179 ILENGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLDPRFIR 243
            ::.:  :.|:..:..|     |.|.:.|.|.|     .|....|:.:|:.|:  |..|..|.|.:
  Fly   456 VIVH--LPLDREIVSN-----YTLSVVATDKG-----TPPLHASKSIFLRIT--DVNDNPPEFEQ 506

Mouse   244 EFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNS--TRPGWFDI-REDGVIFVNGSLDR 305
            :.|.|:|.|.|..|||||.|.|.|.|:|:|..:|||::.:  |...||.| .:.|:|.....:| 
  Fly   507 DLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHID- 570

Mouse   306 EQLLLENEEVQIQVTATEKNLNIYGQEAKASMWVTIRVTDVNDHKP----EFYNCSLPGCSFSPQ 366
                .|.|.|. |:|...::..:....:.|::.|||.  ||||::|    .|||.|         
  Fly   571 ----CETEPVP-QLTVVARDGGVPPLSSTATVLVTIH--DVNDNEPIFDQSFYNVS--------- 619

Mouse   367 EAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAEAFNVSPERAAGSVSVQV 431
                     |.|:......|  |.:.|.|||.|.|.    .:|....|.|....|....|.|.::
  Fly   620 ---------VAENEPVGRCI--LKVSASDPDCGVNA----MVNYTIGEGFKHLTEFEVRSASGEI 669

Mouse   432 VVRNSEMVDYEKETVMVVEVVATDSVSNNYSVATVTIHLRNINDHRPVFSQSLYELTVPEHCPTG 496
            .:...  :|:|:.:.....|:|||. ....:.|.:.:.|.::||:||||....|::::.|.....
  Fly   670 CIAGE--LDFERRSSYEFPVLATDR-GGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKAS 731

Mouse   497 YLVTD----KIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSGNLTVKNGTLLDREKQAVYYLT 557
            ...:.    .:.|||.|...:|.::|.::.||.|.:|.::.::|.:.|....:|....|.::.|.
  Fly   732 SQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLN 796

Mouse   558 LQATDGGN--QSTTTALEITLLDINDNPPVV-RGSYNVFVPEE--NGNVSVTIQAYDDDQPDTNN 617
            :.||||||  .:....:.::::|....||:. :..||.:|.|:  .|.|..::.|...|.  .:.
  Fly   797 ISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDV--AHR 859

Mouse   618 SLLVFSLLPGPYSSNFSLDPNTGLLRNLGPLDREAIDPALEGRIVLTVIVADCGEPSLSTNVNVT 682
            |.:.:|:..|.....||::.|:|.:|...|||.||     :.:::|. |.|..|||.:..:..|.
  Fly   860 SPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEA-----KSQVLLN-IQATLGEPPVYGHTQVN 918

Mouse   683 ITVEDINDNLPVFNQS-YEFSVWERVP-GAWVGTVKAWDADQTAANNRISFSL---SGTGANNFI 742
            |.|||:|||.|.|..| ...||.|... ||.:....|.|.| :.::.::::||   ||.|.  |.
  Fly   919 IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKD-SGSSGQVTYSLVKESGKGL--FA 980

Mouse   743 LQGNVLEQGWAEGSLWLLPDVRLDYETQKFFHLTVSAENPGPQGLDSTANVTVTVMDVNDEPPTL 807
            :...         |..|:....||||:.:...|.|:|.:.|...|.:...:.|.|.||||.||..
  Fly   981 IDAR---------SGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVF 1036

Mouse   808 DAASLQAISVTENGSEHGQVTRVIAQDVDTAALLRI--ELVDVICTKAGVDVGSVCHGWFSVD-- 868
            :... .:::|:|:.|.:.|:.:|.|.|:||....||  .:||     ||||  :|.:...|.|  
  Fly  1037 EKDE-YSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD-----AGVD--NVTNSISSSDVS 1093

Mouse   869 -------GNGSVYINQSEAIDYEACHLVTLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPY 926
                   .:|.:|:.  ..:|.|......|.|    |.||.|..|..:...:::.:.|.|||.|.
  Fly  1094 QHFGIFPNSGWIYLR--APLDRETRDRYQLTV----LATDNGTPAAHAKTRVIVRVLDANDNDPK 1152

Mouse   927 FLPNNQTFVIIPELVLPNQQVASVQARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQVFRITRSV 991
            |..:...| .|.|.:.....|..|.|.|.|..:|..|.:|:|.                 |..|.
  Fly  1153 FQKSKYEF-RIEENLRRGSVVGVVTASDLDLGENAAIRYSLLP-----------------INSSF 1199

Mouse   992 EAGLFTGSIELVTNLDSTIQGTYQVTVQAQDQPTLGPALETQTTLNLFTVDQSYRVRLQFSTSKE 1056
            :....||.|.....||..::..|.:.|:|:||.|  |.             :|.||.::...|  
  Fly  1200 QVHPVTGEISTREPLDRELRELYDLVVEARDQGT--PV-------------RSARVPVRIHVS-- 1247

Mouse  1057 DVGANMEEIKE------ALIQATRTSVYVVTIQNID-----------STARARASSYMDAYFVFS 1104
            ||..|..||.:      ::.:.......||.::.:|           |..:.|.|   |.:.:||
  Fly  1248 DVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDS---DGHGLFS 1309

Mouse  1105 NGTALTLTELNMMIRKDQDALRQLLQLGLVVVSSQESQEPDQQKLLTSVIIGLVVSLVLVLVILI 1169
            ......:....:::..::   |.:.:||   |::.:...|.::             .|.:|.:.:
  Fly  1310 IDPTSGVIRTRVVLDHEE---RSIYRLG---VAASDGGNPPRE-------------TVRMLRVEV 1355

Mouse  1170 TALVCLRKSYHRKLRAMKAGKEARK-------TPIETTAPTAAIPGTNMYNTDRANPVLDLPTKD 1227
            ..|...|.::.......:..::|..       :|||..|..........:...|....|:..|||
  Fly  1356 LDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKD 1420

Mouse  1228 LGLECHSSSDLDYDSLNSLDENSVDLDMDSKEFK 1261
            |   ..::.|:|..|.|.:....:|.::.| ||:
  Fly  1421 L---IEAAFDIDRHSGNLVVARLLDREVQS-EFR 1450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdhr2NP_001028536.2 Cadherin_repeat 33..120 CDD:206637 26/96 (27%)
Cadherin_repeat 128..236 CDD:206637 24/115 (21%)
Cadherin_repeat 246..349 CDD:206637 38/105 (36%)
Cadherin_repeat 372..476 CDD:206637 25/103 (24%)
Cadherin_repeat 485..582 CDD:206637 24/102 (24%)
Cadherin_repeat 589..691 CDD:206637 33/103 (32%)
Cadherin_repeat 698..802 CDD:206637 30/108 (28%)
Cadherin_repeat 815..923 CDD:206637 33/118 (28%)
Cadherin_repeat 934..1042 CDD:206637 26/107 (24%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9BYE9 1178..1308 19/91 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1251..1308 4/11 (36%)
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637 5/15 (33%)
Cadherin_repeat 291..389 CDD:206637 26/98 (27%)
Cadherin_repeat 406..500 CDD:206637 23/111 (21%)
Cadherin_repeat 509..607 CDD:206637 38/105 (36%)
Cadherin_repeat 616..711 CDD:206637 28/121 (23%)
Cadherin_repeat 719..820 CDD:206637 23/100 (23%)
Cadherin_repeat 832..927 CDD:206637 33/102 (32%)
Cadherin_repeat 937..1032 CDD:206637 30/106 (28%)
Cadherin_repeat 1040..1149 CDD:206637 33/122 (27%)
Cadherin_repeat 1158..1252 CDD:206637 32/128 (25%)
Cadherin_repeat 1263..1361 CDD:206637 17/119 (14%)
Cadherin_repeat 1369..1481 CDD:206637 19/86 (22%)
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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