Protein Alignment GFAP and vim

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001128275.1
• Gene: vim / 496727
• XenbaseID: XB-GENE-493024
• Length: 461
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 246/480 - (51%)
• Similarity: 334/480 - (69%)
• Gaps: 55/480 - (11%)

Human     4 RRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLA-----------RMPPP-LPTRVDFSLAG 56
            |.:||:.|.|..|:  |..|..:...|:...|..|.|           .:||. |...|||:||.
 Frog    24 RYVTSSTRYSLGSA--MRPGAGSSSSRVVYSTSASPAVFKSSSVRLRSSLPPARLADTVDFTLAD 86

Human    57 ALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELR 121
            |:|..:|..|.:|:|||.|||||||::|:||||||||||.|.|||.||:.|..:::.|:|:.|:|
 Frog    87 AVNLEYKANRTNEKAEMQELNDRFANFIDKVRFLEQQNKILVAELEQLKGKGTSRIGDLYEEEMR 151

Human   122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDL 186
            |||.:|||:|....|:||:|||||.||..:|:|||||...:.|||.||.::||:.|.|:|||:||
 Frog   152 ELRRQLDQVTNAKDRVEVDRDNLADDLQRLREKLQDEMIQKEEAEGNLQSFRQDVDNASLARIDL 216

Human   187 ERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMH 251
            |||:|||:|||.||:|:|:||:||||.|:....:.|::||:||||||||:::|.|||.:|:.|:.
 Frog   217 ERKVESLQEEIVFLKKLHDEEIRELQLQIQESHIQVDMDVSKPDLTAALRDVRQQYENVAAKNLS 281

Human   252 EAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEER 316
            :||:||:||||||::||.||.:.|||||.:|||||||:|:|||::::::|:|||.||||||.||.
 Frog   282 DAEDWYKSKFADLSEAANRNNDALRQAKQDANDYRRQIQTLTCEIDAMKGSNESYERQMREMEEN 346

Human   317 HVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPV 381
            ...|||:||:.:.||:||..::|:||||||:|||||||||:|||||||||||||||||:|||:||
 Frog   347 FAGEAANYQDTIQRLQEEIHNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRITVPV 411

Human   382 QTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVSEGHLKR 446
            .:||::.:                                        |||:||:..| |.|.||
 Frog   412 HSFSSMSL----------------------------------------RETNLDSHPV-ESHSKR 435

Human   447 NIVVKTVEMRDGEVIKESKQEHKDV 471
            .:::||||.|||:||.||.|.|.|:
 Frog   436 TLLIKTVETRDGQVINESSQHHDDL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	23/73 (32%)
		Filament	68..376	CDD:459643	191/307 (62%)
vim	NP_001128275.1	Filament_head	6..97	CDD:461414	23/74 (31%)
		Filament	98..406	CDD:459643	191/307 (62%)