Protein Alignment GFAP and prph

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_001001235.1
• Gene: prph / 407916
• XenbaseID: XB-GENE-493857
• Length: 456
• Species: Xenopus tropicalis
• Alignment Length: 487
• Identity: 236/487 - (48%)
• Similarity: 331/487 - (67%)
• Gaps: 68/487 - (13%)

Human     5 RITSAARR-----------SYVSSGEMMV----GGLAPGRRLGPGTRLSLA----RMPPPLPT-- 48
            |.||.:.|           ||.||..:..    |..:|    ||.:|.|.:    |...|:..
 Frog     7 RSTSTSYRRTFGGPLLSPVSYSSSSRLSTSRHFGSPSP----GPSSRSSSSAFRVRSSTPVRVSL 67

Human    49 -RVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKL 112
             |||||:|.|:|..|..||::|:||:.||||||||:|||||:|||||..|..|:||.|:||||:.
 Frog    68 DRVDFSVAEAVNQEFLTTRSNEKAELQELNDRFASFIEKVRYLEQQNAVLVTEINQARSKEPTRA 132

Human   113 ADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEAD 177
            :|:.|.||||||.:|:.|..:..|::|||||||:|||.::|:|.:|.:.|.:|||||..:|::.|
 Frog   133 SDLCQQELRELRRQLELLGKDRDRIQVERDNLAEDLAFLKQRLDEEVHKREDAENNLVLFRKDVD 197

Human   178 EATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAK-PDLTAALKEIRTQ 241
            :|||:||:||||||||.:||.||:|:||||:.::|..:..|.:|:|::.|| ||||:||::||:|
 Frog   198 DATLSRLELERKIESLMDEIEFLKKLHEEELNDVQVTVQAQPIHMEIEAAKQPDLTSALRDIRSQ 262

Human   242 YEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESL 306
            ||.:|:.|:.|:||||:||||||:|||.||:|.|||||.:.|:.|||:|||||:::.|:||||:|
 Frog   263 YETIAAKNLQESEEWYKSKFADLSDAATRNSEALRQAKQDMNESRRQIQSLTCEIDGLKGTNEAL 327

Human   307 ERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLE 371
            .|||::.||:...||::||:.:.|||:|.|.:|:||:|||:|||||||||:||||||||||||||
 Frog   328 LRQMKDMEEQFGVEASNYQDTIGRLEQEVQHMKEEMSRHLREYQDLLNVKMALDIEIATYRKLLE 392

Human   372 GEENRITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDT 436
            |||:||.:|:.:.::|.|:.                                    ||.|....|
 Frog   393 GEESRIAVPIHSLTSLSIKS------------------------------------PAPEVDRST 421

Human   437 KSVSEGHLKRNIVVKTVEMRDGE-VIKESKQE 467
                |.|.::.:|:||:|.|||| |:.||::|
 Frog   422 ----EAHTRKTVVIKTIETRDGEQVVTESRKE 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	25/82 (30%)
		Filament	68..376	CDD:459643	186/308 (60%)
prph	NP_001001235.1	Filament_head	10..87	CDD:461414	24/80 (30%)
		Filament	88..397	CDD:459643	186/308 (60%)