Protein Alignment GFAP and des

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_989134.1
• Gene: des / 394739
• XenbaseID: XB-GENE-494931
• Length: 458
• Species: Xenopus tropicalis
• Alignment Length: 473
• Identity: 240/473 - (50%)
• Similarity: 326/473 - (68%)
• Gaps: 54/473 - (11%)

Human     7 TSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTR-------VDFSLAGALNAGFKE 64
            :..|..|.|||....|.      |......||..|.....|.|       :|||||.|:|..|.:
 Frog    33 SKGASSSSVSSRVYQVS------RSSAAPSLSSFRATRVAPVRSSYGADVLDFSLADAMNQEFLQ 91

Human    65 TRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQ 129
            ||.:|:.|:.||||||.:||||||:|||||:.|.||:|:|:.||||::.::|:.|:||||.::|.
 Frog    92 TRTNEKVELQELNDRFVNYIEKVRYLEQQNQILVAEVNKLKGKEPTRVNELYEEEMRELRRQVDL 156

Human   130 LTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194
            .|...:|:|||||||..||..::.:||:|..|:.:|||||||:|.:.|.|||||:||||:||||:
 Frog   157 ATNQRSRVEVERDNLVDDLQKLKLRLQEEIQLKEDAENNLAAFRADVDAATLARIDLERRIESLQ 221

Human   195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRS 259
            |||.||:||||||:||||.|:..||:.||:||:||||||||::||.|||.:|:.|:.||||||:|
 Frog   222 EEIAFLKKIHEEEIRELQAQMQEQQLQVEIDVSKPDLTAALRDIRAQYENIAAKNVSEAEEWYKS 286

Human   260 KFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASY 324
            |.:||..||.:|.:.|||||.|..:||.|:||.||::::|:|||:||.||||:.|||...|||.|
 Frog   287 KVSDLNQAAQKNNDSLRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRDLEERFSGEAAGY 351

Human   325 QEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQI 389
            |:::.|||||.:::||||||||:|||||||||:|||:|||||||||||||:|||:|:||:|.|..
 Frog   352 QDSIGRLEEEIRNMKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESRITLPIQTYSALSF 416

Human   390 RGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVSEGHLKRNIVVKTVE 454
                                                    ||||.:.:: ||.|.|:.:::||:|
 Frog   417 ----------------------------------------RETSPEQRA-SEVHTKKTVMIKTIE 440

Human   455 MRDGEVIKESKQEHKDVM 472
            .|||||:.|:.|:|::::
 Frog   441 TRDGEVVSEASQQHQEIL 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	20/65 (31%)
		Filament	68..376	CDD:459643	191/307 (62%)
des	NP_989134.1	Filament_head	9..94	CDD:461414	21/66 (32%)
		Filament	95..403	CDD:459643	191/307 (62%)