DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GFAP and LamC

DIOPT Version :9

Sequence 1:	XP_024306458.1	Gene:	GFAP / 2670	HGNCID:	4235	Length:	540	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	161/539 - (29%)
Similarity:	244/539 - (45%)	Gaps:	89/539 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKET 65
            |..||:|...|.|..|: ...|||.:...|:|..:        |..|||.              :
  Fly     1 MSARRVTLNTRVSRAST-STPVGGASTSSRVGATS--------PTSPTRT--------------S 42

Human    66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLR---AKEPTKLADVYQAELRELRLRL 127
            |..|:.|:..||||.|.||:::|.||.:|..|..|||..:   .:|.:.|..||:.||...|..|
  Fly    43 RQQEKEELQHLNDRLACYIDRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLL 107

Human   128 DQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAY-RQVREVEGRGRGGRKGLMA 191
            |:.....|:||::...|.::...::.:|..:|.....||||...| .:..||.|:
  Fly   108 DETAKEKAKLEIDIKRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGK---------- 162

Human   192 THPNTAPKLSPPEQCAAPHCPRRRGKARLRNGEKEPGAPVALYSSPLLPLQEADEATLARLDLER 256
            .:.:.|.:....:|.........|.:.:|.:..|:               .||:  ||||:|||.
  Fly   163 YNQSLADRKKFEDQAKELALENERLRRQLDDLRKQ---------------LEAE--TLARVDLEN 210

Human   257 KIESLEEEIRFLRKIHEEEVRELQEQLARQQVHV-ELD-------VAKPDLTAALKEIRTQYEAM 313
            :.:||.||:.|..::|   .:||.|..:|:|:.: |:|       .||  |..:|:|:|.|||..
  Fly   211 QNQSLREELAFKDQVH---TQELTETRSRRQIEISEIDGRLSRQYEAK--LQQSLQELRDQYEGQ 270

Human   314 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQM 378
            ...|..|.|..|.::..:|..||.|.|:....|..|....|.::..|...|::|..||..|..::
  Fly   271 MRINREEIELLYDNEIQNLKAAANRAAQGSALATEEVRLMRTKIDGLNAKLQNLEDTNAGLNARI 335

Human   379 REQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEEN 443
            ||.|.....|...:.:.:|.||.|.|.::||||..|||||.|:::|::||:|||.|.|||.|||.
  Fly   336 RELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQGLMDIKVSLDLEIAAYDKLLCGEER 400

Human   444 RITIPVQTFSNLQIRGGKSTKDG---ENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTK 505
            |:        |::..|..:|..|   ....:|....|.:.||           ||..|.::....
  Fly   401 RL--------NIESPGRPTTDSGISSNGSHLTASASSRSGRV-----------TPSGRRSATPGI 446

Human   506 SVSEGHLKRNIVVKTVEMR 524
            |.|....:|..|:...|.|
  Fly   447 SGSSAVKRRRTVIDESEDR 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	XP_024306458.1	Filament_head	4..66	CDD:309741	15/61 (25%)
GFAP	XP_024306458.1	Filament	68..444	CDD:306535	126/387 (33%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	126/387 (33%)
		ATP-synt_B	<67..>142	CDD:304375	22/74 (30%)
		MreC	<178..>224	CDD:302802	17/62 (27%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910