Protein Alignment GFAP and gfap

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_571448.2
• Gene: gfap / 30646
• ZFINID: ZDB-GENE-990914-3
• Length: 444
• Species: Danio rerio
• Alignment Length: 486
• Identity: 292/486 - (60%)
• Similarity: 344/486 - (70%)
• Gaps: 58/486 - (11%)

Human     1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPT---------------RV 50
            ||.:|..|:.|:.:.:.|.....|:......|   ||||...|..|.:               |:
Zfish     1 MESQRSFSSYRKRFGTPGGSPSVGVTSRHSTG---RLSLHSSPRHLTSSPLTLSTSRLSLGGERL 62

Human    51 DFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADV 115
            |||....|.|.::|||.:|:.|||.||||||||||||||||||||.|.|||||||.|||::|.|:
Zfish    63 DFSADSLLKAQYRETRTNEKVEMMGLNDRFASYIEKVRFLEQQNKMLVAELNQLRGKEPSRLGDI 127

Human   116 YQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEAT 180
            ||.||||||.::|.|.|..||||:||||||.||.|::|:|||||.||.||||||..:||:.|||.
Zfish   128 YQEELRELRRQVDGLNAGKARLEIERDNLASDLGTLKQRLQDETALRQEAENNLNTFRQDVDEAA 192

Human   181 LARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAM 245
            |.|:.||||||:|::||.||:|:||||:|||.|||..|||||:|||:||||||||||||.|:|||
Zfish   193 LNRVQLERKIEALQDEINFLKKVHEEEMRELHEQLMAQQVHVDLDVSKPDLTAALKEIRAQFEAM 257

Human   246 ASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQM 310
            |:|||.|.|||||||||||||||.||.|.|||||.||||||||:|.||||||||||:|||||||:
Zfish   258 ANSNMQETEEWYRSKFADLTDAANRNGEALRQAKQEANDYRRQIQGLTCDLESLRGSNESLERQL 322

Human   311 REQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEEN 375
            :|.|||...|.|.||:.:||||:|.|.||:||||||||||||||||||||||||||||||||||:
Zfish   323 KEMEERFAIETAGYQDTVARLEDEIQMLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEES 387

Human   376 RITIPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVS 440
            |||:|||.|:|||.                                        |:||:|||...
Zfish   388 RITVPVQNFTNLQF----------------------------------------RDTSMDTKLTP 412

Human   441 EGHLKRNIVVKTVEMRDGEVIKESKQEHKDV 471
            |.|:||:|||:|||.||||:||||..|.||:
Zfish   413 EAHVKRSIVVRTVETRDGEIIKESTTERKDL 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	19/76 (25%)
		Filament	68..376	CDD:459643	232/307 (76%)
gfap	NP_571448.2	Head	1..84		24/85 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		14/48 (29%)
		Filament_head	5..79	CDD:461414	20/76 (26%)
		Filament	80..388	CDD:459643	232/307 (76%)
		Coil 1A	85..116		27/30 (90%)
		Linker 1	117..127		5/9 (56%)
		Coil 1B	128..226		64/97 (66%)
		Linker 12	227..242		10/14 (71%)
		Coil 2A	243..264		17/20 (85%)
		Linker 2	265..268		1/2 (50%)
		Coil 2B	269..389		96/119 (81%)
		Tail	390..444		35/94 (37%)