Protein Alignment GFAP and Gfap

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_058705.2
• Gene: Gfap / 24387
• RGDID: 2679
• Length: 430
• Species: Rattus norvegicus
• Alignment Length: 472
• Identity: 396/472 - (83%)
• Similarity: 410/472 - (86%)
• Gaps: 42/472 - (8%)

Human     1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKET 65
            |||||||| |||||.|| |.||.|..|.|.||...||||:||.||||.|||||||||||||||||
  Rat     1 MERRRITS-ARRSYASS-ETMVRGHGPTRHLGTIPRLSLSRMTPPLPARVDFSLAGALNAGFKET 63

Human    66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    64 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQL 128

Human   131 TANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEE 195
            |.||||||||||||.|||.|:|||||||||||||||||||.||||||||||||:|||||:|||||
  Rat   129 TTNSARLEVERDNLTQDLGTLRQKLQDETNLRLEAENNLAVYRQEADEATLARVDLERKVESLEE 193

Human   196 EIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSK 260
            ||:||||||||||||||||||:||||||:|||||||||||:||||||||:|:|||.|.|||||||
  Rat   194 EIQFLRKIHEEEVRELQEQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSK 258

Human   261 FADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQ 325
            ||||||.|:|||||||||||||||||||||:||||||||||||||||||||||||||.||:||||
  Rat   259 FADLTDVASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQ 323

Human   326 EALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIR 390
            ||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   324 EALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQI- 387

Human   391 GGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVSEGHLKRNIVVKTVEM 455
                                                   ||||||||||||||||||||||||||
  Rat   388 ---------------------------------------RETSLDTKSVSEGHLKRNIVVKTVEM 413

Human   456 RDGEVIKESKQEHKDVM 472
            |||||||||||||||||
  Rat   414 RDGEVIKESKQEHKDVM 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	46/61 (75%)
		Filament	68..376	CDD:459643	286/307 (93%)
Gfap	NP_058705.2	Head	1..70		55/70 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		22/31 (71%)
		Filament_head	4..64	CDD:461414	46/61 (75%)
		Filament	66..374	CDD:459643	286/307 (93%)
		Coil 1A	71..102		30/30 (100%)
		Linker 1	103..113		9/9 (100%)
		Coil 1B	114..212		89/97 (92%)
		Linker 12	213..228		12/14 (86%)
		Coil 2A	229..250		17/20 (85%)
		Linker 2	251..254		1/2 (50%)
		Coil 2B	255..375		113/119 (95%)
		Tail	376..430		53/93 (57%)