Protein Alignment GFAP and ifa-3

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_510649.3
• Gene: ifa-3 / 181699
• WormBaseID: WBGene00002051
• Length: 581
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 139/522 - (26%)
• Similarity: 229/522 - (43%)
• Gaps: 122/522 - (23%)

Human     5 RITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASE 69
            |:......::.||   :..||:|   .|.|...::                       ::.|..|
 Worm    36 RVLKIVTETHTSS---VASGLSP---YGQGAASTI-----------------------RDDRERE 71

Human    70 RAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRA---------------------------- 106
            :.|:.|||||.||||.|||||..||:.|.|:||.|::
 Worm    72 KKEITELNDRLASYIGKVRFLAAQNRKLEADLNVLQSRFGKSTGSVKIMYEMEITTATNVVKETG 136

Human   107 -------KEPTKLADVYQAELR-----------ELRLRLDQLTANSARLEVERDNLAQDLATVRQ 153
                   ||..|:.|... |||           |.||::|:|....:.||.|.:.|.:.:|.:.:
 Worm   137 KDHEEAEKEIGKIKDQLD-ELRKKFEEAQKGRAEDRLKIDELLVTLSNLEAEINLLKRRIALLEE 200

Human   154 ---KLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQL 215
               :|:.| |.||.:|  |...|.|.|:.||.|:|.:.|:.::.|||.|:::..|.|:::||.|.
 Worm   201 EVARLKKE-NFRLTSE--LQRVRSELDQETLLRIDNQNKVTTILEEIDFMKRGFETELKDLQAQA 262

Human   216 ARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADL-TDAAARNAELLRQAK 279
            ||.......:..|.:|..::::||.:|:...:.|.::.|.|.:.:..:: |....:|||:    .
 Worm   263 ARDTTSENREYFKNELMNSIRDIRAEYDRFMAGNRNDLESWSQIRVQEINTQTNRQNAEI----N 323

Human   280 HEANDYRRQLQSLTCDLES----LRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKD 340
            |:.::.:| |.|...:|:|    |...|..||:|:.:...:...:..||:.||...:.:.:.|::
 Worm   324 HKRDEVKR-LHSQVSELKSKHAELAARNGLLEKQLEDLNYQLEDDQRSYEAALNDKDAQVRKLRE 387

Human   341 EMARHLQEYQDLLNVKLALDIEIATYRKLLEG--EENRITIPVQTFSNLQIRGGKSTKDGENHKV 403
            |....|.|.|.||:.|..||.|:..||::|||  |||.:...|:                   ||
 Worm   388 ECQALLVELQMLLDTKQTLDGELKVYRRMLEGNSEENGLRQLVE-------------------KV 433

Human   404 TRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEH 468
            .|  .|.....:..:..::|.|...:| ||....:      |.|:.:|.|......||.|:....
 Worm   434 VR--TSAINEEVDTETMRVVKGEHSSR-TSYQRSA------KGNVSIKEVSPEGKFVILENTHRD 489

Human   469 KD 470
            |:
 Worm   490 KE 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	8/60 (13%)
		Filament	68..376	CDD:459643	111/363 (31%)
ifa-3	NP_510649.3	solA	<15..>86	CDD:236887	18/78 (23%)
		Filament	71..419	CDD:459643	107/356 (30%)
		LTD	464..570	CDD:460003	8/34 (24%)