Protein Alignment GFAP and Gfap

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: XP_030101431.1
• Gene: Gfap / 14580
• MGIID: 95697
• Length: 470
• Species: Mus musculus
• Alignment Length: 472
• Identity: 422/472 - (89%)
• Similarity: 445/472 - (94%)
• Gaps: 3/472 - (0%)

Human     1 MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKET 65
            |||||||| |||||.|  |.:|.||.|.|:||...|.||:||.||||.|||||||||||||||||
Mouse     1 MERRRITS-ARRSYAS--ETVVRGLGPSRQLGTMPRFSLSRMTPPLPARVDFSLAGALNAGFKET 62

Human    66 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    63 RASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQL 127

Human   131 TANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEE 195
            |||||||||||||.||||.|:||||||||||||||||||||||||||||||||:|||||:|||||
Mouse   128 TANSARLEVERDNFAQDLGTLRQKLQDETNLRLEAENNLAAYRQEADEATLARVDLERKVESLEE 192

Human   196 EIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSK 260
            ||:|||||:|||||||:||||:||||||:|||||||||||:||||||||:|:|||.|.|||||||
Mouse   193 EIQFLRKIYEEEVRELREQLAQQQVHVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSK 257

Human   261 FADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQ 325
            ||||||||:|||||||||||||||||||||:||||||||||||||||||||||||||.||:||||
Mouse   258 FADLTDAASRNAELLRQAKHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQ 322

Human   326 EALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIR 390
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   323 EALARLEEEGQSLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIR 387

Human   391 GGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSLDTKSVSEGHLKRNIVVKTVEM 455
            ||||||:||..||||.||.|||:|:|||||||.||..||.|||||||||||||||||||||||||
Mouse   388 GGKSTKEGEGQKVTRPLKRLTIQVVPIQAHQIENGALPAAETSLDTKSVSEGHLKRNIVVKTVEM 452

Human   456 RDGEVIKESKQEHKDVM 472
            |||||||:||||||||:
Mouse   453 RDGEVIKDSKQEHKDVV 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	44/61 (72%)
		Filament	68..376	CDD:459643	287/307 (93%)
Gfap	XP_030101431.1	Filament_head	4..63	CDD:461414	44/61 (72%)
		Filament	65..373	CDD:459643	287/307 (93%)