Protein Alignment GFAP and ina

DIOPT Version :10

• Sequence 1: NP_001350775.1
• Gene: GFAP / 2670
• HGNCID: 4235
• Length: 472
• Species: Homo sapiens
• Sequence 2: XP_004915909.1
• Gene: ina / 100101732
• XenbaseID: XB-GENE-492716
• Length: 491
• Species: Xenopus tropicalis
• Alignment Length: 488
• Identity: 214/488 - (43%)
• Similarity: 303/488 - (62%)
• Gaps: 59/488 - (12%)

Human    14 YVSSGEMMVGGLAP---GRRLG----------PGTRL-SLARM-PPPLPT--------------R 49
            |:||....:.|..|   ..|||          .|.|. ||:|. .|..|:              .
 Frog     8 YLSSSYRKIFGDPPRASSARLGVSSSSRATATSGYRSHSLSRSNVPSAPSYRRASRGAGYLAGDN 72

Human    50 VDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAK--EPTKL 112
            :|.:...|:|..:|..|.:|:.::..||||||.:||||..||||||.|..||..||.:  ||::|
 Frog    73 LDLTQTSAVNNEYKIIRTNEKEQLQGLNDRFAMFIEKVHNLEQQNKVLETELTALRQRQSEPSRL 137

Human   113 ADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEAD 177
            .::||.|::|||.:|::|.|..|::.:|||||..||..::.|.:||..:|.|.|..|.:::::.|
 Frog   138 GELYQQEIKELRAQLEELNAEKAQIIIERDNLEDDLQKLKGKYEDEIRMREETEYALKSHKKDVD 202

Human   178 EATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQY 242
            :|||||||||:|:|||.:||.||||:|:|||.||...|...||.||::::|||||:||||||:||
 Frog   203 DATLARLDLEKKVESLLDEISFLRKVHDEEVTELMAMLQASQVSVEMELSKPDLTSALKEIRSQY 267

Human   243 EAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLE 307
            |::|:.|:..|:|||:||||:||:.|:|:.||:|..:.|.|||||||||.|.::|||||||||||
 Frog   268 ESLAAKNLQSADEWYKSKFANLTEQASRSTELIRANREEINDYRRQLQSKTIEIESLRGTNESLE 332

Human   308 RQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEG 372
            ||::|.|:||:.|.|..|:.:.:||.|.::.|.||||||:|||||||||:|||||||.|||||||
 Frog   333 RQLQEMEDRHMAETAGLQDTINQLENELRNTKGEMARHLREYQDLLNVKMALDIEIAAYRKLLEG 397

Human   373 EENRIT---IPVQTFSNLQIRGGKSTKDGENHKVTRYLKSLTIRVIPIQAHQIVNGTPPARETSL 434
            ||.|.:   |.:..|:       .:.....::: :|...|.|.:|.|                ::
 Frog   398 EETRFSTAGISMMPFN-------PNPPPSYSYQ-SRVHSSSTSKVTP----------------AV 438

Human   435 DTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQE 467
            |::...|......:|.|: ..|.||..:|..:|
 Frog   439 DSRKKEETDGVSKVVSKS-STRIGETYEEIIEE 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GFAP	NP_001350775.1	Filament_head	4..66	CDD:461414	19/80 (24%)
		Filament	68..376	CDD:459643	177/309 (57%)
ina	XP_004915909.1	Filament_head	8..90	CDD:461414	19/81 (23%)
		Filament	91..401	CDD:459643	177/309 (57%)