Protein Alignment AMFR and sip3

DIOPT Version :9

• Sequence 1: NP_001310441.1
• Gene: AMFR / 267
• HGNCID: 463
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_001263152.1
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 684
• Identity: 156/684 - (22%)
• Similarity: 256/684 - (37%)
• Gaps: 213/684 - (31%)

Human    76 YLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFW--------NFIFY---- 128
            |:...:..:.|:......::.:..||:..|..|.||.:|.:||.::||        .|..:
  Fly    33 YITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETCLAFTVFRDDF 97

Human   129 --KFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPMSSHGRVLSLLV 191
              :|:.:|.|                  |:||.....|.::|.:::..||......|.||.|||
  Fly    98 NPRFVALFTV------------------LLFLKSFHWLAEERVDFMERSPVLGWLFHIRVGSLL- 143

Human   192 AMLLSCCGLAAVCSITGYTHGMHT------------LAFMAAESLLVTVRTAHVILRYVIHLWDL 244
                      .|..|..|...:|.            |.|....::|:|| .|...::||:|..::
  Fly   144 ----------TVLGILDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTV-IASTAIKYVLHAAEM 197

Human   245 NHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRI 309
            ..:..||.|..::.||:.|:.|..:.|       .:||..|...:.:|.:|: .|.:|..: |..
  Fly   198 RTDTPWENKAVFLLYTELVIGLIKVVL-------YILFVVIMAKIYALPMFV-FRPMFFTI-RNF 253

Human   310 RRHKNYL----RVVGNMEARFAVATPEELAVNNDDCAICWDSM-QAARKLPCGHLFHNSCLRSWL 369
            |:..|.:    |.:.||...:..||||||..:::.|.||.:.| ..::||||||:||.:|||||.
  Fly   254 RKALNDVIMSRRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWF 318

Human   370 EQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGDDSSMRVT 434
            ::..:|||||  |||.....|.........||   .||||.|.|             ..::..|.
  Fly   319 QRQQTCPTCR--LNILRTPTVNSTAMPRQGDE---AVAAAAGNP-------------IPAAAGVQ 365

Human   435 APEDVPVGQEVEVVDSD---------------TDAPDLWSRIASWLPSFSVEVMHTTNILG---- 480
            ....||......|||.:               .:..||:.. ||.||:      ...|:.|
  Fly   366 PAGGVPPPAPTAVVDGNQARADVNVAGGQALPPNFADLFGD-ASGLPN------GLPNLAGLQIP 423

Human   481 -------------------------------ITQASNSQLNAMAHQIQEMFPQVPYHLVLQDLQL 514
                                           :|..::.:|.||....::       |:| |.|:|
  Fly   424 PPPVMPMISPFMIPPHFGYLTPLPPPPIPQDLTNFTDEELRAMEGLQRD-------HIV-QRLKL 480

Human   515 TRSVEITTDNI---------LEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSA------ 564
            .:::.:..|:.         |..|:|:...|..:     |:|...:  ||..:...|||
  Fly   481 LQNINLMLDSAGIMMSQYQSLSARLQLTAVTPAT-----AVNGSAD--SSVYDMPSTSATAMAQL 538

Human   565 QTERV-PLDLSPRLEETLDFGEVEVE---------------------PSEVEDFEARGSRFSKSA 607
            :|.:| |...:.....|:...:|.:|                     |:...|||...|...:
  Fly   539 ETHQVTPTAAASSASPTMPAEKVTIEDLGADADEDDIPSTATEAVSIPNSDADFEENSSELGE-- 601

Human   608 DERQRMLVQRKDELLQQARKRFLNKSSEDDAASE 641
                          |::.|.:||.:.::..|.:|
  Fly   602 --------------LRKRRLKFLEERNKSAATNE 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMFR	NP_001310441.1	None
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	104/388 (27%)
		zf-RING_2	287..328	CDD:290367	20/40 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1478
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770