Protein Alignment AMFR and hrd1

DIOPT Version :9

• Sequence 1: NP_001310441.1
• Gene: AMFR / 267
• HGNCID: 463
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_596376.1
• Gene: hrd1 / 2539900
• PomBaseID: SPBC17D11.02c
• Length: 677
• Species: Schizosaccharomyces pombe
• Alignment Length: 547
• Identity: 118/547 - (21%)
• Similarity: 210/547 - (38%)
• Gaps: 155/547 - (28%)

Human    74 AQYLLSDS-LFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVL 137
            |..::|.| :.:.:.:|...|:...:|..::.::||.|:..|.:.|.::||       |.:..::
pombe    31 ATVMISQSPVHITIGLNVCLCLFFAIANALKTLLFGSLQTFELELLYEQFW-------ITLTEIM 88

Human   138 NVQTV--EEV-VMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPT-------TPMSSHGRVLSLLVA 192
            ...||  |.: :.:.:..:.|:|..:...:|..|.|.|....|       :.::....|||:|.|
pombe    89 LAITVFREAISISFFMLLSTLMFARVFHSICSFRTERLQIQLTDQRFHIFSRLTCAYFVLSILDA 153

Human   193 MLLSCCGLAAVCSITGYTHGMHT--LAFMAAESLL---VTVRTAHVILRYVIHLWDLNH-EGTWE 251
            .|:..|       .|....|..:  :.|:...|:|   :|:..:    :..|:|::..| :..|:
pombe   154 SLIYLC-------FTSEHLGDKSTRMLFVCEFSVLLLNLTIEAS----KLCIYLYEARHLDQVWD 207

Human   252 GKGTYVYYTDFVME-LTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNY 315
            .|.||::..:...: |.||:..|   :.|..|..:.:.:.|:   .|:...|:.:.||||.|..:
pombe   208 EKSTYLFRLEVCRDGLRLLAYSL---LFMYQFPYVSVPIYSI---RQMYTCFYSLFRRIREHARF 266

Human   316 LRVVGNMEARFAVATPEELAVNNDDCAICWDSM---------------------QAARKLPCGHL 359
            .:...:|.|.:..||.|:|..::..|.||.:.|                     ...::|||||:
pombe   267 RQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPLPRGLDMTPKRLPCGHI 331

Human   360 FHNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHF 424
            .|..|||:|||:..:||.||.|:
pombe   332 LHFHCLRNWLERQQTCPICRRSV------------------------------------------ 354

Human   425 DGDDSSMRVTAPEDVPVGQEVEVVDSDTDAPDLWSRIASWLPSFSVEVMHTTNILGITQASN--- 486
            .|:.||     |..:|....|......|..|:         |.   ....||.:.|||.:||
pombe   355 IGNQSS-----PTGIPASPNVRATQIATQVPN---------PQ---NTPTTTAVPGITNSSNQGD 402

Human   487 ---SQLNAM--------AHQIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFP-TQRS 539
               |..|.:        |...|::...:|..:.|:|                |...:|.| |:|.
pombe   403 PQASTFNGVPNANSSGFAAHTQDLSSVIPRRIALRD----------------GWTMLPIPGTRRI 451

Human   540 DSIRPALNSPVERPSSDQEEGETSAQT 566
            .:.  :.::....||:....|:.|..|
pombe   452 PTY--SQSTSTTNPSATPTTGDPSNST 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMFR	NP_001310441.1	None
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	118/547 (22%)
		zf-RING_2	291..351	CDD:290367	18/59 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810