Protein Alignment AMFR and hrdl-1

DIOPT Version :9

• Sequence 1: NP_001310441.1
• Gene: AMFR / 267
• HGNCID: 463
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_492602.2
• Gene: hrdl-1 / 172833
• WormBaseID: WBGene00009164
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 673
• Identity: 152/673 - (22%)
• Similarity: 271/673 - (40%)
• Gaps: 160/673 - (23%)

Human     6 LERFPWPSLRTYTGLSGLALL---GTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSA-- 65
            |.|..:||:.:|..||.|..:   .|:.:.:|  ||||        |...::.|.....|.|:
 Worm    22 LSRSSFPSVDSYLALSVLVAIVASVTVFTTFR--SQPE--------LQKLIEEELRNNTRLSSAY 76

Human    66 -------GGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFW 123
                   .|.....:|.|:|||:..:||.:|:...:|.:..:||..:.|..|...|....:..|:
 Worm    77 GLNIEALSGHTFFQIAHYILSDTTLIWVAINSYFAILAVCTRLIIKLTFKELARQEENVARQAFF 141

Human   124 NFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFL-HLMVQLCKDRFEYLSFSPTTPMSSHGRVL 187
            .::....:::..|:..|....|:.|.:|.....|| ||....|: |.:::|     |....|...
 Worm   142 CYVLLTIVYLSVVIGPQKGHRVMPWMIWGGICAFLSHLQFITCQ-RLKHIS-----PSCDRGSQK 200

Human   188 SLLVAMLLSCCGLAAVCSITGYTHGM--HTLAFMAAESLLVTVRTAHVILRYV--IHLWDLN--- 245
            ...:::.|....:|....|:.:.|.:  .....:..:.||...|:.:::.|.:  ..::..|
 Worm   201 ISFLSLFLFFVSIAMTFLISRFQHHLTWQPAVLLYFDCLLAVFRSTYILFRCISSSRVFSFNPDS 265

Human   246 --HEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNI-----WLSMASLVIFMQLRYLFH 303
              |...|     ....|:||.||          |.||.|..:     .|::.|:.....::..::
 Worm   266 VRHFNYW-----LELITNFVCEL----------IQMLSFAQLLAFSPGLNLTSIFFLYHMKLTYN 315

Human   304 EVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDD-CAICWDSMQAARKLPCGHLFHNSCLRS 367
            .:..::.||:|:.::..::|..:    |.....|.|| |.:||:.:..:|:|||.|.||:.||..
 Worm   316 CMTEQLSRHRNHKKIFEHIERSY----PSVKCANGDDRCVVCWELLGTSRRLPCSHQFHDWCLMW 376

Human   368 WLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH-FFHFDGDDSSM 431
            ||.||:||||||.::. :..:::|:.           |......|.|.|..:. |.||
 Worm   377 WLAQDSSCPTCRCTIP-SPQDQIRQP-----------PEVGNSTRLRFNGGSFGFVHF------- 422

Human   432 RVTAPEDVPVGQEVEVVDSDTDAPDLWSRIASWLPSFSVEVMHTTN-ILG-ITQASNSQLNAMAH 494
                                              |:|::||..... ..| ..:.:..||..|..
 Worm   423 ----------------------------------PAFTLEVAANFGPFFGRAAEPTEEQLQTMLE 453

Human   495 QIQEMFPQVPYHLVLQDLQLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEE 559
            |::|||||:...:::.||:.:.|.:.|.:|||||||.:      :.|..|  ...::...||:.|
 Worm   454 QVREMFPQMSVDIIMTDLRQSGSAQSTIENILEGRIGM------NASFMP--GGVLDDELSDESE 510

Human   560 GETSAQTERVPLDLSPRLEETLDFGEVEVEPSEVEDFEARGSR------FSKSADERQRMLVQRK 618
            .|...:                       ||:|:......|.:      .|.|.||.......::
 Worm   511 NEIEYE-----------------------EPAEIVQEPDNGRQRTWTKLSSSSGDEDLSYYEIQR 552

Human   619 DELLQQARKRFLNKSSEDDAASE 641
            .::::..|:::|    |.|.|::
 Worm   553 AKMIETYRRKYL----ESDKAAD 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMFR	NP_001310441.1	None
hrdl-1	NP_492602.2	HRD1	<200..>407	CDD:227568	54/237 (23%)
		zf-RING_2	348..388	CDD:290367	21/39 (54%)
		CUE_AMFR	449..489	CDD:270604	16/39 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161472038
Domainoid	1	1.000	63	1.000	Domainoid score	I7431
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H888
Inparanoid	1	1.050	163	1.000	Inparanoid score	I3239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55068
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0006872
OrthoInspector	1	1.000	-	-		oto22436
orthoMCL	1	0.900	-	-		OOG6_105132
Panther	1	1.100	-	-	LDO	PTHR15067
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3836
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770