Protein Alignment ADGRF1 and mthl4

DIOPT Version :9

• Sequence 1: NP_722582.2
• Gene: ADGRF1 / 266977
• HGNCID: 18990
• Length: 910
• Species: Homo sapiens
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 113/543 - (20%)
• Similarity: 200/543 - (36%)
• Gaps: 141/543 - (25%)

Human   410 NISTLVPPTALPLNFSRKFIDWKGIPVNKSQLK-----RGYSYQIK-----MCPQ---------- 454
            |.|.|.....:|.:.:.:: |:| :..:.|:.|     ||.:..::     .|||
  Fly    39 NGSYLYEGLLIPAHLTAEY-DYK-LLADDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCY 101

Human   455 --------NTSIPIRGRVLIGSDQFQRSLPETIISMASLT---------LGNILPVSKNGNAQVN 502
                    |...|.....|......:|...|.:|..:.|.         |.:.||    ||.
  Fly   102 GDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELP----GNE--- 159

Human   503 GPVISTVIQNYSINEVFLFFSKIESNLSQPHCVFWDFSHLQWNDAGCHLVNETQDIVTCQCTHLT 567
                .|:.:|.|:   ...:.|:|.: .:.:||    .||.:.|.
  Fly   160 ----FTLFENGSL---LRHWDKVELS-KREYCV----QHLSFKDD-------------------- 192

Human   568 SFSILMSP-FVPSTIFPVVKWITYVGLGISIGSLILCLIIEALFWKQIKKSQTSHTRRICMVNIA 631
              ||.::| |.|.:......|.| |.:.||    ::|:|:....:..::|.:..|.:  |.:...
  Fly   193 --SIRIAPHFCPLSSEHSRTWKT-VAIVIS----LICIILTISVYLYVEKLRNLHGK--CFICYL 248

Human   632 LSL------LIADVWFIVGATVDTTVNPSGVCTAAVFFTHFFYLSLFFWMLMLGILLAYRIILV- 689
            .||      |:.:||          ...||.|..|.|..:|..::.|||:.::||.|..:..|.
  Fly   249 ASLFLGYFFLVLNVW----------KYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLAS 303

Human   690 --FHHMAQHLMMAVGFCLGYGCPLIISVITIAVTQPSNTYK---RKDV---CWLNWSNGSKPLLA 746
              .|.:.............:|.|||::.||....|.....|   |..|   ||: ::.....::.
  Fly   304 NCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWI-YTGDMTVMIY 367

Human   747 FVVPALAIVAVNFVVVLLVLTKLWRPTVGERLS------------RDDKATIIRVGKSLLILTPL 799
            |..|.|.::|.|  :::.||:.::...:.:.:.            .|.:...|     .|.|..|
  Fly   368 FYGPMLLLIAFN--IIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAI-----FLRLFIL 425

Human   800 LGLTWGFGIGTIVDSQNLAWH---VIFALLNAFQGFFILCFGILLDSKLRQLLFNKLSAL----- 856
            :||:|.|.|.:.:.::..||.   ::....|..||..|....||..|.|:.::......|
  Fly   426 MGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHH 490

Human   857 SSWKQTEKQNSSDLSAKPKFSKP 879
            :|..:..:.||:..:.:...:.|
  Fly   491 NSRSKAARYNSTHTACEGSIADP 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRF1	NP_722582.2	SEA	154..>215	CDD:279699
		GPS	532..572	CDD:280071	6/39 (15%)
		7tm_4	582..834	CDD:304433	63/281 (22%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	38/204 (19%)
		7tm_4	213..>385	CDD:304433	45/191 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8337
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760