DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MDGA1 and Sr-CIII

DIOPT Version :9

Sequence 1:	XP_006715119.1	Gene:	MDGA1 / 266727	HGNCID:	19267	Length:	973	Species:	Homo sapiens
Sequence 2:	NP_524747.1	Gene:	Sr-CIII / 44382	FlyBaseID:	FBgn0020376	Length:	320	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	46/194 - (23%)
Similarity:	78/194 - (40%)	Gaps:	41/194 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   747 NLSDNTCHFEDEKICGYTQDLTDNFDWTRQNA----LTQNPKRSPNTGPPTDISGTPEGYYMFIE 807
            ::.|::|.||.|.:||:.........|.|.:|    |.:...:..:|     .....||:::.::
  Fly   137 SVGDHSCDFEREDMCGWRASKAIPQPWKRISAAADFLKEKCLQQDHT-----FQSDVEGHFIRLQ 196

Human   808 T----SRPRELGDRARLVSPLY------NASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDT 862
            :    ||      ....:||:|      ..|..|   .|...|:|..:.:|.:.|:..:....|
  Fly   197 SQVHASR------TYHFISPIYPRNLTVGHSLWF---QFELFMFGSEVRNLTISVKPSSMAVED- 251

Human   863 HAW----------SLSGNKGNVWQQAHVPISP-SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGE 915
             .|          ::||::|..|:...:.|.. ...||::|..|......|||.||||...|.|
  Fly   252 -MWNSFRNICTKLTVSGDQGPNWKSQSISIDEMESDFQVVFTVVDPSSLHGDIGIDDVKFIKSE 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MDGA1	XP_006715119.1	IG_like	46..126	CDD:214653
		IGc2	52..115	CDD:197706
		IG_like	152..217	CDD:214653
		Ig	153..217	CDD:143165
		IG_like	248..326	CDD:214653
		IGc2	254..315	CDD:197706
		IGc2	350..418	CDD:197706
		IG_like	450..535	CDD:214653
		IGc2	455..515	CDD:197706
		Ig	541..622	CDD:299845
		IG_like	543..631	CDD:214653
		MAM	753..917	CDD:279023	45/188 (24%)
		MAM	753..916	CDD:99706	45/188 (24%)
Sr-CIII	NP_524747.1	CCP	27..>62	CDD:153056
		MAM	143..310	CDD:279023	43/182 (24%)
		MAM	143..310	CDD:99706	43/182 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910