DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MDGA1 and igcm-1

DIOPT Version :9

Sequence 1:	XP_006715119.1	Gene:	MDGA1 / 266727	HGNCID:	19267	Length:	973	Species:	Homo sapiens
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	888	Identity:	177/888 - (19%)
Similarity:	294/888 - (33%)	Gaps:	261/888 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    44 SERVYTIREG-DTLMLQCLVT----GHPRPQVRWTKTAG------SASDKF-----------QET 86
            |...|.::|| :.:::.|:|.    ...:.::.|.:...      :.:||.           .::
Worm    32 SSEPYFLQEGNEGIVIPCVVKPEYFDRQKYEINWARYNNGQLRMITKNDKLLAKKHSRFILENDS 96

Human    87 SVFNETLRIERIARTQ-GGRYYCKAENGVGVPAIKSIRVDVQYL-----------DEPMLTVHQT 139
            :..|.:|||..:.:.. .|.|:|   |.:|..     ..||||.           .:|:::...:
Worm    97 ATGNYSLRITEVEKNSVEGTYHC---NVIGTD-----DSDVQYSALATVVVLVPPGDPIISTTPS 153

Human   140 VSDVRGNFYQEKTVFLRCTVNSNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETK-VLKLKN 203
            .|.:.|:|...|.|    :|..:|...|.|...:||::.|.     |:...:..|.|: :|..:.
Worm   154 ESVIEGDFMTAKCV----SVGGSPQPTFTWTLPNDTIASSA-----IFTTQFRDGATESLLHFRV 209

Human   204 LRPQDYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLV---VNPGENVTVQCLLT 265
            ....|..|..|.|:.|.:.|...|.:.....|....|.:.::..|.|.   |..||.|.:.|...
Worm   210 TSSDDGKSVQCDVTNRAMLGGETKQVKSSQLNVLYKPVVFVTPTENLTHLSVEEGELVNLTCNSA 274

Human   266 GGDPLPQLQWSH--------------------------------GPGPL---------------- 282
            ...|....:|.|                                |.|..
Worm   275 SNPPAHSYEWKHIASGERYQGKIWPIRVDSSMSGDFECRSTNELGEGTAVLKMVVQHIPRINVPE 339

Human   283 -----------------------------PLGALAQGGTLSIPSVQARDSGYYNCTATN------ 312
                                         |.|....|..|:|.|:....||.|.|.|||
Worm   340 SISPNEMEDIDILCEVSAVPEVIDIKWVGPNGFKQNGSRLTITSISKAQSGNYTCMATNFLTVYG 404

Human   313 NVGNPAKKTVNLLVRSMKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKP 377
            :.|:..:......:..:|....|  ..::...:|:.:|:.:||.|..:.......:|.|   ..|
Worm   405 HSGSQQRMGTGTTIVDVKRKPGQ--AQIVSARQNVDVGETIKLMCQAEDAGNPSASYTW---ASP 464

Human   378 ARMSKRLLVTRNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTI 442
            :  |..:.......|     .|.|:.:...||.|.|.|.|      ..||. |..|.  ||..|:
Worm   465 S--SGGIFGLEGHTE-----KSFEVRNAQLSDNGVYSCKA------YNDLG-EGKIG--TVMITV 513

Human   443 SVPKGR---AVVTVREGSPAE----LQCEVRGKPRPPVLW-------------SRVDKEAALLPS 487
             :.|.|   .:.|.|..:..|    |:||.:|.|.|.:.|             |....|:..||.
Worm   514 -IEKARISSPLATERIFTSGEQGKILECEAQGYPSPVIKWLKDGRPVKQSIYASSATSESKCLPE 577

Human   488 GLPLEE-----TPDGKLRLERVSRDMSGTYRCQTARYNGFN-----------VRPREAQVQLNVQ 536
            ....:.     |..|.|:...     .|.:.|  ...||.:           ||.....|.||.:
Worm   578 DFCTQTVASTLTLAGPLKWSD-----KGNFTC--VADNGSDKTDKDSSSWTIVRVLHKPVFLNRK 635

Human   537 FPPEVEPSSQDVRQALGRPVLLRCSL-LRGSPQRIASAVWRFKGQLLPPPPVVPAAAE------- 593
            | ||...::.|:    |...::||.: .|..|:    ..|.|:...:         :|
Worm   636 F-PEKSLAAADI----GSQAIIRCKVSARPEPE----FHWMFRDSEI---------SENERHSFH 682

Human   594 ------APDHAE--LRLDAVTRDSSGSYECSVSNDVGSAACLFQVSAKAYSPEFYFDTPNPTRSH 650
                  .||..|  |::::|.....|.|.|..:|..|....:.:: .|...|..      |....
Worm   683 TVGITGKPDEYEQLLQIESVQESDYGEYVCRATNGNGGDHVVIEL-RKTSPPAL------PLDLQ 740

Human   651 KLS-KNYSYVLQWTQREPDAVDPVLNYRLSIRQLN------QHNAVVKAIPVRRVEKGQLLE--- 705
            ||| .:.|.:|.|..:.....|.  .|.|..|:::      ..||.|..:.:..|::.|.::
Worm   741 KLSATSNSVLLGWVPQFDGGADQ--TYVLETRKIDPFTGEIDGNAPVSKLNINAVQQDQEIDGTL 803

Human   706 -----YILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYTEPI 743
                 :..|.|....:|.:|:...:..|..:....:|..||.:
Worm   804 VSKNIFNFTGLTPLSTYNLRIQAVSEKGESEFTPVLIASTEDV 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MDGA1	XP_006715119.1	IG_like	46..126	CDD:214653	17/102 (17%)
		IGc2	52..115	CDD:197706	15/85 (18%)
		IG_like	152..217	CDD:214653	15/65 (23%)
		Ig	153..217	CDD:143165	15/64 (23%)
		IG_like	248..326	CDD:214653	26/163 (16%)
		IGc2	254..315	CDD:197706	22/143 (15%)
		IGc2	350..418	CDD:197706	16/67 (24%)
		IG_like	450..535	CDD:214653	25/117 (21%)
		IGc2	455..515	CDD:197706	16/81 (20%)
		Ig	541..622	CDD:299845	18/96 (19%)
		IG_like	543..631	CDD:214653	19/103 (18%)
		MAM	753..917	CDD:279023
		MAM	753..916	CDD:99706
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	11/73 (15%)
		Ig	146..226	CDD:299845	21/88 (24%)
		Ig_3	245..316	CDD:290638	11/70 (16%)
		IG_like	258..329	CDD:214653	10/70 (14%)
		IG_like	338..398	CDD:214653	11/59 (19%)
		IGc2	347..398	CDD:197706	11/50 (22%)
		Ig_2	429..513	CDD:290606	24/102 (24%)
		IG_like	437..513	CDD:214653	23/94 (24%)
		Ig	537..615	CDD:143165	18/84 (21%)
		IG_like	644..728	CDD:214653	19/101 (19%)
		IGc2	646..719	CDD:197706	17/89 (19%)
		FN3	733..843	CDD:238020	23/117 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910