DRSC/TRiP Functional Genomics Resources

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Protein Alignment GDF2 and scw

DIOPT Version :10

Sequence 1:NP_057288.1 Gene:GDF2 / 2658 HGNCID:4217 Length:429 Species:Homo sapiens
Sequence 2:NP_524863.3 Gene:scw / 46000 FlyBaseID:FBgn0005590 Length:400 Species:Drosophila melanogaster


Alignment Length:427 Identity:95/427 - (22%)
Similarity:160/427 - (37%) Gaps:127/427 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    63 KVDFLRSLNLSGVPSQDKTRVEP------PQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISIT 121
            :::.:..|:|...|   :.:.||      .::::::||..:.|:......:.....|::|.|.|:
  Fly    39 QMEMIDILDLGDRP---RRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLDDDILIS 100

Human   122 ATE----------------------DFPFQKHILLFNISIPRHEQITRAELRLY----------- 153
            ..:                      |.....||......:|....:.:|.||:|           
  Fly   101 NEDRQEIASCNSILTFSSRLKPEQLDNELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRAN 165

Human   154 --VSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVR 216
              ||....:|...|..     |.:|...:...|              ..||....::..::.|:.
  Fly   166 FTVSVYRKLDNRQDFS-----YRILGSVNTTSS--------------QRGWLEFNLTDTLRYWLH 211

Human   217 SDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNL--PFFVVFSNDHSSGTKETRLELREMISHE 279
            :...:.:|:|.:::...:.......:..|..||..  ||.|.:.|......|..:|..:..:   
  Fly   212 NKGLQRRNELRISIGDSQLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDL--- 273

Human   280 QESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGS----------------HCQ 328
                                                 .||.||.||                .|:
  Fly   274 -------------------------------------EKRRAGGGSPPPPPPPPVDLYRPPQSCE 301

Human   329 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACC 393
            :.:..|:|:::...:|:||||::|||.|.|||.|||...:..|.|||||||:|||.| .:.|.||
  Fly   302 RLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP-HLPKPCC 365

Human   394 VPTKLSPISVL-YKDDMGVPTLKYHYEGMSVA-ECGC 428
            |||.|..|::| |.::..:...||.   .:|| ||||
  Fly   366 VPTVLGAITILRYLNEDIIDLTKYQ---KAVAKECGC 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GDF2NP_057288.1 TGFb_propeptide 70..217 CDD:480997 30/187 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 283..308 0/24 (0%)
TGF_beta_BMP9 325..429 CDD:381670 49/122 (40%)
Interaction with ENG. /evidence=ECO:0000269|PubMed:28564608 402..416 2/14 (14%)
scwNP_524863.3 TGFb_propeptide 39..254 CDD:480997 38/236 (16%)
TGF_beta_BMP5_like 299..400 CDD:381639 48/105 (46%)

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