DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RGS17 and Axn

DIOPT Version :9

Sequence 1:	NP_036551.3	Gene:	RGS17 / 26575	HGNCID:	14088	Length:	210	Species:	Homo sapiens
Sequence 2:	NP_733336.1	Gene:	Axn / 43565	FlyBaseID:	FBgn0026597	Length:	745	Species:	Drosophila melanogaster

Alignment Length:	194	Identity:	41/194 - (21%)
Similarity:	90/194 - (46%)	Gaps:	34/194 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    43 VRNEERGENAG-RPTHTTKMESIQVLEECQNPTAE----EVLSWSQNFDKMMKAPAGRNLFREFL 102
            :|..:..|.:| ||....:...::.:.|....|::    ..|:|::..:.:::...|..||::::
  Fly     8 IRKHDDNECSGPRPPVPGEESRVKKMTEGVADTSKNSSPSYLNWARTLNHLLEDRDGVELFKKYV 72

Human   103 RTE---YSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLL 164
            ..|   |: ::|.|:.|||.||::.:.:.|::....||.    .|...::|:...:|..|.....
  Fly    73 EEEAPAYN-DHLNFYFACEGLKQQTDPEKIKQIIGAIYR----FLRKSQLSISDDLRAQIKAIKT 132

Human   165 DP----NPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVE-----------------STAGSS 207
            :|    :||:::..|..:...:..:.:|.||.|::|..:::                 .:||||
  Fly   133 NPEIPLSPHIFDPMQRHVEVTIRDNIYPTFLCSEMYILYIQQMSAQQERCTSSGATGSGSAGSS 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RGS17	NP_036551.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
RGS17	NP_036551.3	RGS	41..197	CDD:413378	36/165 (22%)
Axn	NP_733336.1	RGS	55..170	CDD:295367	28/119 (24%)
		Axin_b-cat_bind	494..543	CDD:285982
		DIX	665..739	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910