DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDF1 and scw

DIOPT Version :9

Sequence 1:	NP_001374367.1	Gene:	GDF1 / 2657	HGNCID:	4214	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_001286088.1	Gene:	scw / 46000	FlyBaseID:	FBgn0005590	Length:	400	Species:	Drosophila melanogaster

Alignment Length:	137	Identity:	48/137 - (35%)
Similarity:	65/137 - (47%)	Gaps:	20/137 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   250 RPRRDAEPVLGGG---------------PGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQ 299
            |.:||.|....||               |..:|......|.|:|:..|.|||||:.|.|.:|.|.
  Fly   268 RFKRDLEKRRAGGGSPPPPPPPPVDLYRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGG 332

Human   300 CALPVALSGSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDM 364
            |..|:....:    |.|||:::.|||...|.... |||||..|..|::|.:.|.|.:.|.:|:..
  Fly   333 CNFPLGTKMN----ATNHAIVQTLMHLKQPHLPK-PCCVPTVLGAITILRYLNEDIIDLTKYQKA 392

Human   365 VVDECGC 371
            |..||||
  Fly   393 VAKECGC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDF1	NP_001374367.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..86
GDF1	NP_001374367.1	TGF_beta_GDF1_3_like	267..372	CDD:381642	41/105 (39%)
scw	NP_001286088.1	TGFb_propeptide	39..254	CDD:279078
scw	NP_001286088.1	TGFB	300..400	CDD:214556	41/105 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810