DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ncdn and Neurochondrin

DIOPT Version :9

Sequence 1:	NP_036116.3	Gene:	Ncdn / 26562	MGIID:	1347351	Length:	729	Species:	Mus musculus
Sequence 2:	NP_649658.1	Gene:	Neurochondrin / 40796	FlyBaseID:	FBgn0037447	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	739	Identity:	206/739 - (27%)
Similarity:	347/739 - (46%)	Gaps:	103/739 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    43 LREAKNDSEQFAALLLVTKAVKAGDIDAKTRRRIFDAVGFTFPNRLLTTKEAPDGCPDHVLRALG 107
            |:..|:|:|:||||.:|||.||..|.:|..::.:|:|:||.|..:||.:|:.|:.||..|.:::.
  Fly    15 LKGTKSDTEKFAALFMVTKLVKGKDCNAAGKKLLFEAIGFPFLKKLLVSKDLPNDCPPLVYKSVA 79

Mouse   108 VALLACFCSDPELASHPQVLNKIPILSTFLTARGDPDDAARRSMIDDTYQCLTAVAGTPRGPRHL 172
            :::|.|||.:.|||:|..:::.||.|...:....|.|......::.:.|.||.::|....|.:.|
  Fly    80 LSILTCFCQEEELATHKDIIDAIPTLLEIVEQADDEDYEDNLIVVSEAYSCLKSIASHEPGQQAL 144

Mouse   173 IAGGTVSALCQAYLGHGYGFDQALALLVGLLAAAETQCWKEAEPDLLAVLRGLSEDFQRAEDASK 237
            :|.|.:..:.|.|....:..|:||.|:|.|:.......|.|......|:::.::.|.:..:...|
  Fly   145 LATGAIPKMSQIYSAQSFQTDEALHLIVLLVKQFGVVSWPEDPTAFHALIQRIALDMETDDTERK 209

Mouse   238 FELCQLLPLFLPPTTVPPECHRD--------------LQAGLARILGSKLSSWQRNPALKLAARL 288
            :|||::|      ..:...|.|:              |..|...||.:|:...||:|||.|.|..
  Fly   210 YELCRIL------ADILITCRREIVINSLEGQIWPESLFKGCGDILKAKIGPKQRDPALHLIATT 268

Mouse   289 AHACGSDWIPVGSSGSKFLALLVNLACVEVRLALEETGTEV---KEDVVTACYALMELGIQECTR 350
            .|..|..|..:....:.||.|| .|..:|||:.::|...|.   :.:::|.|::::|..| |...
  Fly   269 LHVLGIQWAFMDEQKTFFLQLL-QLGAIEVRMQMDEKKLETTFKQAELLTCCFSILEHCI-EYMA 331

Mouse   351 CEQSLLKEPQKVQLVSIMKEAIGAVIHYLLQVGPEKQKE-------PFVFASVRILGAWLAEETS 408
            .:|..|:..:|....:.:|.|...|:..|.:|..:|.:|       .||||.|::|.||||:||:
  Fly   332 TDQLDLEPKEKQTTYTALKGAFNQVLAVLTRVSQDKIRESSNPKDKKFVFAIVKVLSAWLAQETT 396

Mouse   409 SLRKEVCQLLPFLVRYAKTLYEEAEEASDISQQVANLAISPTTPGPSW---------PGDALRLL 464
            ::|..:.:||||:::.|...::|.:                     :|         |.|.||::
  Fly   397 AMRPAIYKLLPFMLKVANESFQELK---------------------TWRAGTREGEPPIDVLRIM 440

Mouse   465 LPGWCHLTVEDGPREILIKEGAPSLLCK----YF-LQQWE------------LTSPGHDTSVLPD 512
            ||..||..||:..|.:|.......:|.:    || :..|:            :..|  |....|:
  Fly   441 LPALCHFAVEEEARRVLFTHKQDEVLLESLEFYFSIAHWKRPPIPRAERLKRMNEP--DPVPTPE 503

Mouse   513 S------VEIGLQTCCHIFLNLVVTAPGLIKRDACFTSLMNTLMTSLPSLVQQQGRLLLAANVAT 571
            .      ....:...|:|.:|..|..|...:....|.:|:..::.:||.|......|::..|:|.
  Fly   504 QQAEMKVARSAIVALCNILMNFTVLEPKKAEDGPTFANLLKFVVENLPELKDTPDNLVIHGNLAV 568

Mouse   572 LGLLMARLLSTSPALQGTPASRGFFAAAILFLSQSHVARATPGSDQAVLALSPDYEGIWADLQEL 636
            ||||:.:..|...........| :..|.|.||..::  .....:|...|.:|..|:|.|:||.||
  Fly   569 LGLLLLKQQSKKVKQNDFSICR-YIQATIRFLWDAY--NIDESNDPTALVVSIAYKGYWSDLSEL 630

Mouse   637 WFLGMQAFTGCVPLLPWLAPAALRSRWPQELLQLLGSVSPNSVKPEMVAAYQGVLVELARAN--- 698
            ||||||...|.:||:|||:..||.|.|.:.:::.|..|...::...:.:||:..|.:|...|
  Fly   631 WFLGMQTMCGVLPLVPWLSEFALESGWAEGIVKTLKKVKIGTLPANVKSAYEDFLSQLVDVNGDV 695

Mouse   699 ----------RLCREAMRLQAGEE 712
                      |:||....:..|::
  Fly   696 QAVLKKADALRVCRNHRMMDLGKK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ncdn	NP_036116.3	Neurochondrin	30..637	CDD:336138	178/649 (27%)
Neurochondrin	NP_649658.1	Neurochondrin	2..631	CDD:283244	178/649 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835049
Domainoid	1	1.000	256	1.000	Domainoid score	I2023
eggNOG	1	0.900	-	-		E1_KOG2611
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8064
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2679
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49523
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007454
OrthoInspector	1	1.000	-	-		oto91940
orthoMCL	1	0.900	-	-		OOG6_106255
Panther	1	1.100	-	-	LDO	PTHR13109
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4680
SonicParanoid	1	1.000	-	-		X6328
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790