Protein Alignment LATS2 and CBK1

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_014238.3
• Gene: CBK1 / 855561
• SGDID: S000005105
• Length: 756
• Species: Saccharomyces cerevisiae
• Alignment Length: 735
• Identity: 249/735 - (33%)
• Similarity: 378/735 - (51%)
• Gaps: 118/735 - (16%)

Human   407 NSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPA- 470
            |..|.:|..|.||             .|..:::.:....|.:.|:...|...|.....:...||
Yeast    37 NEMNPYQQIPRPP-------------AAGFSSNYMKEQGSHQSLQEHLQRETGNLGSGFTDVPAL 88

Human   471 --PAPAPAP------------APAPAAEGLDAKEEHALAL-------GGA-------GAFPLDVE 507
              || .|.|            .|.|:..||.....::.::       |.|       |.:.::.|
Yeast    89 NYPA-TPPPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLSPGQYSIESE 152

Human   508 YG-GPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGME--QSLRAGPNEPEGGDKSRK--SAKGDK 567
            |. ..:......|:.:...|||..      |..:|:.  :|.:....|.|.....::  .|:...
Yeast   153 YNQNLNGSSSSSPFHQPQTLRSNG------SYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQN 211

Human   568 GGKDKKQIQTSPVPVRKN-------SRDEEKRESRIKSYSPY----------------------- 602
            ..:.::|:|......::.       .:.:::::.:.:|.||.
Yeast   212 SRQQQQQLQYQQQQQQQQQQQHMQIQQQQQQQQQQQQSQSPVQSGFNNGTISNYMYFERRPDLLT 276

Human   603 --------AFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNR 659
                    |.|..:|...::.:|...::..||::||.|:......|..:.:....|.:|||.:.|
Yeast   277 KGTQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNWSEERKSRQLSSLGKKESQFLR 341

Human   660 LKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAE 724
            |:|.::....|..:|.:|.||||||.|..|.||..:||||||.|.::..::|:||||||||:||.
Yeast   342 LRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAG 406

Human   725 ADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF 789
            :|:.|||.|||||||...||.:|:::||||:|::|||.::|.|.:.|||:||..||||::||:||
Yeast   407 SDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGF 471

Human   790 IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDS-----MEPSDL---WDD 846
            |||||||||||||:.|||||:||||.|||..||:|.||:|  .::||.     .:|...   ..|
Yeast   472 IHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKK--LLQQDEATNGISKPGTYNANTTD 534

Human   847 VSNCR---CGDRLK-TLEQRAR----KQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGV 903
            .:|.|   ..|.:. |:..|.:    ::.:|.:|:|.||||:|||||:.|.:||.|.|||||:|.
Yeast   535 TANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGA 599

Human   904 ILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRN-GAD 967
            |::|.|:|.|||.:.||.||..|::|:|.||..|..:.:|.||.|||.:|...||.||||: |||
Yeast   600 IMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGAD 664

Human   968 DLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVD--EESPWNDASEGSTKAWDTLTSP 1030
            ::|:||||..:|::: ||:..|||:|.:|...|| .|.|.|  |..|.:.|...:.|..:.:|..
Yeast   665 EIKSHPFFRGVDWNT-IRQVEAPYIPKLSSITDT-RFFPTDELENVPDSPAMAQAAKQREQMTKQ 727

Human  1031 NNKHP---EHAFYEFTFRRF 1047
            ....|   :..|..:|:.||
Yeast   728 GGSAPVKEDLPFIGYTYSRF 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..521	CDD:223021	27/143 (19%)
		MobB_LATS2	587..669	CDD:439272	20/112 (18%)
		STKc_LATS2	668..1048	CDD:173715	191/402 (48%)
CBK1	NP_014238.3	MobB_CBK1	269..341	CDD:439268	14/71 (20%)
		STKc_NDR_like_fungal	350..748	CDD:270778	191/402 (48%)