Protein Alignment LATS2 and lats2

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_001116779.2
• Gene: lats2 / 567674
• ZFINID: ZDB-GENE-050119-6
• Length: 1140
• Species: Danio rerio
• Alignment Length: 1199
• Identity: 717/1199 - (59%)
• Similarity: 823/1199 - (68%)
• Gaps: 168/1199 - (14%)

Human     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPN---SDTSLDAKVLGSKDATRQQQ 62
            |||||||||.|.||:|||||:|:||||||:|...|.|..|.:   .....|:|   .||...:||
Zfish     1 MRPKTFPATPYVGNTRQRLQDIKEGLKQPAKLVSQALHGGSSRGEGGRGGDSK---GKDQAARQQ 62

Human    63 QMRATPKFGPYQKALREIRYSLLPFANESGTSAAA----EVNRQMLQELVNAGCDQEMAGRALKQ 123
            |:|...||..||.||||||.||.|:||:||..:::    ||:|||||:|||||||||||.|||||
Zfish    63 QLRPPQKFNNYQSALREIRKSLRPYANDSGPGSSSGHPGEVSRQMLQDLVNAGCDQEMAVRALKQ 127

Human   124 TGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGD-SFASYHQLS 187
            ||||:|||||||||||.||||..||||||||||||||..||..:..|.:.||:|| :...|||:.
Zfish   128 TGSRNIEAALEYISKMSYLDPHTEQIVRVIKQTSPGKSGMPNLMDHRTAMEGSGDGALPPYHQMG 192

Human   188 GTPYEGPSFGADGPTALEEMPR------PYVDYLFPGVGP------------------------- 221
            ...|||.|:||:|     ||.|      |.::|:.|...|
Zfish   193 APLYEGASYGAEG-----EMARAYMGGPPVMNYMPPPANPSQGATMGNPMGRPASMGAYSTNMAP 252

Human   222 --------HGPGHQHQHPPKGYGASVEAAGAHF-----PLQ---------GAHYG-RPHLLVPGE 263
                    :.||...|   |||.:.::.|...:     |:|         ||||. |.|::   |
Zfish   253 QNNTGNPMYTPGPAQQ---KGYPSGIDQAMMGYSVSGPPMQIQSQPSGGPGAHYDYRSHMM---E 311

Human   264 PLGYGVQRSPSFQSKTPP-ETGGYASLPTKGQGGPPGAGLAFPPPAAGLYV-PHPHHKQAGPVAH 326
            ...|||:||.|||:|.|. .|..|.::|:|...|....|.     |..||: ||.|.:||.|.:|
Zfish   312 NSSYGVKRSASFQNKMPQLTTENYVNMPSKAAMGQNAGGY-----APNLYLPPHSHPRQASPTSH 371

Human   327 QLHVL--------GSRSQVFASDSPPQSLLTPSRNSLNVDLYELSSTSVQQWPAATLARRDSLQK 383
            |:|::        |:....|:  ..||.||||||.|||:||||      ..||.|
Zfish   372 QVHMMQRPPGVAPGAMGGEFS--DVPQGLLTPSRASLNLDLYE------HHWPGA---------- 418

Human   384 PGLEAPPRAHV---AFRPDCPVPSRTNSFNSHQ---------PRPGPPGKAEPSLPAPNTVTAVT 436
            .|.|..|.|..   .||.:..|||||||||:||         |.....||.|.||..|||:||||
Zfish   419 QGPEGTPPARQPQGPFRGEVRVPSRTNSFNNHQKVTVRQTLPPTASVAGKPESSLGPPNTITAVT 483

Human   437 AAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAPAAE-GLDAKEEHALALGGAG 500
            :..|..||||:||:||||:|||||.||.|:.|.:|....:....|... .|:..:||
Zfish   484 SPPIQPPVKSIRVMRPEPKTAVGPCHPGWLSAQSPEAQDSLGYIPDENFTLEPSQEH-------- 540

Human   501 AFPLDVEYGGPDRRCPPPPYPKHLLLR-SKSEQYDLDSLC-AGME---------QSLRAGPNEPE 554
                         |||||||||.||:. |..|...|:.:. :|::         ||...|..|..
Zfish   541 -------------RCPPPPYPKTLLVSGSGPEPASLEPVAMSGLQDVSATGRTIQSSSVGKQEES 592

Human   555 GGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTY 619
            ......|..||:|..||||||||||||||||:|||||||||||||||:||||:||||||||:|||
Zfish   593 IFKDKVKMGKGEKAVKDKKQIQTSPVPVRKNARDEEKRESRIKSYSPFAFKFYMEQHVENVMKTY 657

Human   620 QQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEV 684
            |||:|||:||||||:||||.|||||||||:|||||||||||:|||||||||||||||||||||||
Zfish   658 QQKLNRRMQLEQEMSKAGLSEAEQEQMRKMLYQKESNYNRLRRAKMDKSMFVKIKTLGIGAFGEV 722

Human   685 CLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDY 749
            ||..||||.||||||||||||||||||||||||||||||||||||||:|||||||:|:|||||||
Zfish   723 CLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVRLYYSFQDRDNLYFVMDY 787

Human   750 IPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL 814
            |||||||||||||.||||.|||||:||||||||||||||||||||||||||||||||||||||||
Zfish   788 IPGGDMMSLLIRMGVFPEVLARFYVAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGL 852

Human   815 CTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTP 879
            ||||||||||||||||:|:|||||||||.|||||||||||||.||||||.:||||||||||||||
Zfish   853 CTGFRWTHNSKYYQKGNHIRQDSMEPSDFWDDVSNCRCGDRLMTLEQRATRQHQRCLAHSLVGTP 917

Human   880 NYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSP 944
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.:|.||||||
Zfish   918 NYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLQVPPQVKLSP 982

Human   945 EARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDE 1009
            ||.|:|.:|||||:.|||.|||.::|||||||.:||||::|.|||||.|.|:|||||||||||:|
Zfish   983 EAVDIIGQLCCSAEERLGGNGAGEIKAHPFFSEVDFSSNLRTQPAPYRPKIAHPMDTSNFDPVEE 1047

Human  1010 E---SPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKP----------S 1061
            |   ..|:|:.: ||:.||||.||:.||||||||||||||||||||.|||.|||          .
Zfish  1048 EGGPGAWSDSGD-STRTWDTLCSPHGKHPEHAFYEFTFRRFFDDNGCPFRYPKPLEATQSLSSSD 1111

Human  1062 GAEASQAESSDLESSDLVDQTEGCQPVYV 1090
            ||.:.:.|..:.|:.:..:|.|||:||||
Zfish  1112 GAGSLKPELEEEEAHEEEEQGEGCEPVYV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	36/39 (92%)
		PHA03247	<143..521	CDD:223021	165/455 (36%)
		MobB_LATS2	587..669	CDD:439272	72/81 (89%)
		STKc_LATS2	668..1048	CDD:173715	330/382 (86%)
lats2	NP_001116779.2	UBA_LATS2	105..145	CDD:270581	36/39 (92%)
		PHA03247	<206..565	CDD:223021	140/408 (34%)
		MobB_LATS2	625..707	CDD:439272	72/81 (89%)
		Protein Kinases, catalytic domain	706..1088	CDD:473864	330/382 (86%)