Protein Alignment LATS2 and Lats2

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_056586.2
• Gene: Lats2 / 50523
• MGIID: 1354386
• Length: 1042
• Species: Mus musculus
• Alignment Length: 1095
• Identity: 898/1095 - (82%)
• Similarity: 939/1095 - (85%)
• Gaps: 58/1095 - (5%)

Human     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMR 65
            |||||||||||||||||||||||||||||||:|.|||..||||||||||||||||||:| |||||
Mouse     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKASTQGLLVGPNSDTSLDAKVLGSKDASR-QQQMR 64

Human    66 ATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIE 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    65 ATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIE 129

Human   131 AALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPS 195
            ||||||||||||||||||||||||||||||||.||||||||||||||::..|||||.|..||||:
Mouse   130 AALEYISKMGYLDPRNEQIVRVIKQTSPGKGLAPTPVTRRPSFEGTGEALPSYHQLGGANYEGPA 194

Human   196 FGADGPTALEEMPRPYVDYLFPGVGPHGPGHQ-HQHPPKGYGASVEAAGAHFPLQGAHYGRPHLL 259
                   |||||||.|:|:||||.|....|.| ||||||||..:||.: ||||  |.||||.|||
Mouse   195 -------ALEEMPRQYLDFLFPGAGAGTHGAQAHQHPPKGYSTAVEPS-AHFP--GTHYGRGHLL 249

Human   260 VPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAG-- 322
              .|..|||||||.|||:||||:  .|:|: .|.||||| |.|.| |..||||.. .|||.|.
Mouse   250 --SEQPGYGVQRSSSFQNKTPPD--AYSSM-AKAQGGPP-ASLTF-PAHAGLYTA-SHHKPAATP 306

Human   323 PVAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELSSTSVQQWPAATLARRDSLQKPGLE 387
            |.||.|||||:|...|..:|..|::|.|||||||.|||||.||  ..|.||.|||||||||.|||
Mouse   307 PGAHPLHVLGTRGPTFTGESSAQAVLAPSRNSLNADLYELGST--VPWSAAPLARRDSLQKQGLE 369

Human   388 APPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRP 452
            | .|.|||||..   ||||||||:.||        ||||||||||||||||||||||||||||||
Mouse   370 A-SRPHVAFRAG---PSRTNSFNNPQP--------EPSLPAPNTVTAVTAAHILHPVKSVRVLRP 422

Human   453 EPQTAVGPSHPAWVPAPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPP 517
            ||||||||||||||.||.         |||.|.|:.||      |.||..||||:|||.:|||||
Mouse   423 EPQTAVGPSHPAWVAAPT---------APATESLETKE------GSAGPHPLDVDYGGSERRCPP 472

Human   518 PPYPKHLLLRSKSEQY--DLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPV 580
            |||||||||.||||||  ||||||..::||||.| .|.:..|||.|.|||||.|:||||||||||
Mouse   473 PPYPKHLLLPSKSEQYSVDLDSLCTSVQQSLRGG-TEQDRSDKSHKGAKGDKAGRDKKQIQTSPV 536

Human   581 PVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQ 645
            |||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Mouse   537 PVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQ 601

Human   646 MRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRN 710
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
Mouse   602 MRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRN 666

Human   711 QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIA 775
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   667 QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIA 731

Human   776 ELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 840
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||||
Mouse   732 ELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEP 796

Human   841 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVIL 905
            .||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse   797 GDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVIL 861

Human   906 FEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLK 970
            ||||||||||||||||||||||||||:|||||.||:||.|||||||||||:||.||||:||||||
Mouse   862 FEMLVGQPPFLAPTPTETQLKVINWESTLHIPTQVRLSAEARDLITKLCCAADCRLGRDGADDLK 926

Human   971 AHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHP 1035
            |||||:.||||.|||||||||||||||||||||||||||||||::||..|.||||||.||::|||
Mouse   927 AHPFFNTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPSSKHP 991

Human  1036 EHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV 1090
            ||||||||||||||||||||||||||    ..|||:|...:||....||||||||
Mouse   992 EHAFYEFTFRRFFDDNGYPFRCPKPS----EPAESADPGDADLEGAAEGCQPVYV 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	39/39 (100%)
		PHA03247	<143..521	CDD:223021	246/380 (65%)
		MobB_LATS2	587..669	CDD:439272	80/81 (99%)
		STKc_LATS2	668..1048	CDD:173715	356/379 (94%)
Lats2	NP_056586.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..44		16/20 (80%)
		Interaction with ubiquitinated AMOTL2. /evidence=ECO:0000250|UniProtKB:Q9NRM7	100..140		39/39 (100%)
		UBA_LATS2	100..140	CDD:270581	39/39 (100%)
		PHA03247	<150..513	CDD:223021	263/410 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..282		31/51 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..399		16/31 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..481		28/44 (64%)
		PPxY motif	472..475		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..550		38/49 (78%)
		MobB_LATS2	543..625	CDD:439272	80/81 (99%)
		Protein Kinases, catalytic domain	624..1004	CDD:473864	356/379 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1014..1042		16/31 (52%)