Protein Alignment LATS2 and for

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 135/502 - (26%)
• Similarity: 222/502 - (44%)
• Gaps: 119/502 - (23%)

Human   560 RKSAKGD-----KGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVE------ 613
            |:.|:||     ..||.:       |.:::....|||....:....     ||.|:.::
  Fly   667 RQGARGDTFFIISKGKVR-------VTIKQQDTQEEKFIRMLGKGD-----FFGEKALQGDDLRT 719

Human   614 -NVI--------------KTYQQKVNRRLQLEQEMAKAGLCEAEQ--EQMRKILYQKESNYNRLK 661
             |:|              :|:.|.::...:::......|..|..:  |:.|.|      |...|:
  Fly   720 ANIICESADGVSCLVIDRETFNQLISNLDEIKHRYDDEGAMERRKINEEFRDI------NLTDLR 778

Human   662 RAKMDKSMFVKIKTLGIGAFGEVCLA-CKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEA 725
                      .|.|||:|.||.|.|. ...|:...:|:|.::|..::...|..|:.:|::|:.||
  Fly   779 ----------VIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEA 833

Human   726 DNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFI 790
            :.:::|||:.:|:||..||.:|:...||::.::|.....|.:...|||.|.:..|.:.:|....|
  Fly   834 NCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNII 898

Human   791 HRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDR 855
            :||:||:|:|::..|::||.|||.         :|..|.|
  Fly   899 YRDLKPENLLLNERGYVKLVDFGF---------AKKLQTG------------------------- 929

Human   856 LKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTP 920
                    ||....|      |||.|:||||:|.:|:....|:||:||::||:|.|.|||....|
  Fly   930 --------RKTWTFC------GTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSDP 980

Human   921 TETQLKVINWENTLHIPAQVKLSPEARDLITKLC-CSADHRLG--RNGADDLKAHPFFSAIDF-- 980
            ..|...::...:.:..|..:  :..|.:||.||| .:...|||  |.|..:::.|.:|....:
  Fly   981 MRTYNIILKGIDAIEFPRNI--TRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWG 1043

Human   981 SSDIRKQPAPYVPTISHPMDTSNFD--PVDEESPWNDASEGSTKAWD 1025
            ..:...:| |..|.:...:||:|||  |.|.|.|..|...|    ||
  Fly  1044 LQNCTLEP-PIKPAVKSVVDTTNFDDYPPDPEGPPPDDVTG----WD 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..521	CDD:223021
		MobB_LATS2	587..669	CDD:439272	17/104 (16%)
		STKc_LATS2	668..1048	CDD:173715	111/366 (30%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999
		CAP_ED	638..754	CDD:237999	17/98 (17%)
		STKc_cGK	783..1043	CDD:270724	93/309 (30%)