Protein Alignment LATS2 and Lats2

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_001100737.1
• Gene: Lats2 / 305922
• RGDID: 1305906
• Length: 1042
• Species: Rattus norvegicus
• Alignment Length: 1095
• Identity: 904/1095 - (82%)
• Similarity: 943/1095 - (86%)
• Gaps: 58/1095 - (5%)

Human     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDT-SLDAKVLGSKDATRQQQQM 64
            |||||||||||||||||||||||||||||:|||.|||..|||||| ||||||||:|||:| ||||
  Rat     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPAKSSTQGLLVGPNSDTSSLDAKVLGNKDASR-QQQM 64

Human    65 RATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSI 129
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    65 RATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSI 129

Human   130 EAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGP 194
            |||||||||||||||||||||||||||||||||:||.|||||||||||::|.|:|||.|..||||
  Rat   130 EAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLVPTAVTRRPSFEGTGEAFPSHHQLGGANYEGP 194

Human   195 SFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLL 259
            :       |||||||.|:|:||||...|| ...||||||||..:|: ||.|||  ||||||.|||
  Rat   195 A-------ALEEMPRQYLDFLFPGASVHG-APAHQHPPKGYSTAVD-AGTHFP--GAHYGRAHLL 248

Human   260 VPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAG-- 322
              .|..||||||||||||||||:|  |:|| .|.||||| |.|.| |..||||.. .|||.|.
  Rat   249 --SEQPGYGVQRSPSFQSKTPPDT--YSSL-AKAQGGPP-ASLTF-PAHAGLYTT-SHHKPAAAV 305

Human   323 PVAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELSSTSVQQWPAATLARRDSLQKPGLE 387
            |.||.|||||:|...|..||..|::|.|||||||.|||||.|.  ..||||.|||||||||..||
  Rat   306 PGAHPLHVLGTRGPTFTGDSSTQAVLAPSRNSLNNDLYELGSP--VPWPAAPLARRDSLQKQSLE 368

Human   388 APPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRP 452
            | .|.|||||..   |||||||:|.||        ||||||||||||||||||||||||||||||
  Rat   369 A-SRPHVAFRAG---PSRTNSFSSPQP--------EPSLPAPNTVTAVTAAHILHPVKSVRVLRP 421

Human   453 EPQTAVGPSHPAWVPAPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPP 517
            |||||||||||||||||.       ||| |||||::||      |.||..|||:::||.:|||||
  Rat   422 EPQTAVGPSHPAWVPAPT-------APA-AAEGLESKE------GSAGPPPLDMDFGGSERRCPP 472

Human   518 PPYPKHLLLRSKSEQYD--LDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPV 580
            |||||||||.||||||.  ||.||.|:|||||.| .|.:..||..|.|||||.|:||||||||||
  Rat   473 PPYPKHLLLPSKSEQYSAGLDRLCTGVEQSLRGG-TEQDRNDKGHKGAKGDKAGRDKKQIQTSPV 536

Human   581 PVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQ 645
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||.||||
  Rat   537 PVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCETEQEQ 601

Human   646 MRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRN 710
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   602 MRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRN 666

Human   711 QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIA 775
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   667 QVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIA 731

Human   776 ELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEP 840
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|:|||||||
  Rat   732 ELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEP 796

Human   841 SDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVIL 905
            .||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   797 GDLWDDVSNCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVIL 861

Human   906 FEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLK 970
            ||||||||||||||||||||||||||||||||.|||||.|||||||||||:||.||||:||||||
  Rat   862 FEMLVGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLITKLCCAADCRLGRDGADDLK 926

Human   971 AHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHP 1035
            ||||||.||||.|||||||||||||||||||||||||||||||::||..|.||||||.|||:|||
  Rat   927 AHPFFSTIDFSRDIRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPNSKHP 991

Human  1036 EHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV 1090
            ||||||||||||||||||||||||||    ..|||:|...::|....||||||||
  Rat   992 EHAFYEFTFRRFFDDNGYPFRCPKPS----EPAESADPGDAELGGAVEGCQPVYV 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	39/39 (100%)
		PHA03247	<143..521	CDD:223021	251/379 (66%)
		MobB_LATS2	587..669	CDD:439272	79/81 (98%)
		STKc_LATS2	668..1048	CDD:173715	361/379 (95%)
Lats2	NP_001100737.1	UBA_LATS2	101..141	CDD:270581	39/39 (100%)
		PHA03247	<143..490	CDD:223021	264/393 (67%)
		MobB_LATS2	543..625	CDD:439272	79/81 (98%)
		Protein Kinases, catalytic domain	624..1004	CDD:473864	361/379 (95%)