Protein Alignment LATS2 and wts-1

DIOPT Version :10

• Sequence 1: XP_054230417.1
• Gene: LATS2 / 26524
• HGNCID: 6515
• Length: 1090
• Species: Homo sapiens
• Sequence 2: NP_492699.1
• Gene: wts-1 / 172896
• WormBaseID: WBGene00007047
• Length: 908
• Species: Caenorhabditis elegans
• Alignment Length: 1134
• Identity: 350/1134 - (30%)
• Similarity: 491/1134 - (43%)
• Gaps: 326/1134 - (28%)

Human     1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMR 65
            |||.. |.||.:|.|    .:||.      :..|..:|.| ::::::||         ....::|
 Worm     1 MRPAA-PGTTPNGAS----SDIRH------QRGVAPIPFG-STNSAIDA---------HHNSEIR 44

Human    66 ATPKFGPYQKALREIRYSLLPFANESG------------TSAAAEVNRQML----QELVNAGCDQ 114
            .    |.::..|.|||.||..:.:|:|            |.:::.|:...:    .|::|.....
 Worm    45 V----GRHRAKLDEIRESLKAYEHEAGLLSSHVALGSLATPSSSSVSHSDITNDNAEVMNFSSSS 105

Human   115 EMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDS 179
            ..|........|.::..:..:.::.|                  |..:..||:.:|.....||.:
 Worm   106 SNAAATTTTVSSAAVSNSNSFRTEGG------------------GHKMRITPMPQRHLMMDTGAN 152

Human   180 ---FASYHQL--SGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASV 239
               |.|..::  :|.|  ..:..:...|..||           .:..|..|:::..|...|..:.
 Worm   153 ETVFRSGKEMIRNGNP--STTISSTPSTTTEE-----------SIRIHPAGYRYDMPTPAYHMNN 204

Human   240 EAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAF 304
            .|     |.....|.||
 Worm   205 NA-----PQYSPGYSRP------------------------------------------------ 216

Human   305 PPPAAGLYVPHPHHKQAGPVAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELSSTSVQQ 369
            ||||                                                   |:.|..:.:.
 Worm   217 PPPA---------------------------------------------------YDSSPVNTRM 230

Human   370 WPAATLARRDSLQ---KPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSL----- 426
            .|.||...|..|.   .|.::|||          |.|:..|...:..|.|.||.|:..|:
 Worm   231 TPVATDNYRTHLHMKVHPVVKAPP----------PNPTMLNHNKNMAPPPPPPAKSTISIETMSE 285

Human   427 --PAPN------------TVTAVTAAHILHP-VKSVRV---LRPEPQTAVGPSHPAWVPAP---- 469
              .|.|            |.::|.:.::..| ...|.|   ..|.....:||.:.|.|...
 Worm   286 ERKADNIQRLYHTSMDKKTASSVVSINVASPHTTKVNVGDSPLPSKSFIIGPRYTADVDRKNFVN 350

Human   470 -----APAPAPAPAPAPAAEGLDAKEEHALALGGAGAF-PLDVEYGGPDRRCPPPPYPKHLLLRS 528
                 .|.|...|:.:      ||..|....:    .| |.::|.....|..||||
 Worm   351 YKDELRPDPRLIPSTS------DANHEDFRPI----LFKPRNLEITMKSRAQPPPP--------- 396

Human   529 KSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRE 593
               ||                 |:|......|.|:..|:         |...|..||:|
 Worm   397 ---QY-----------------NQPSEPPPKRVSSPIDR---------TLLEPYIKNTR------ 426

Human   594 SRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYN 658
             |::...|...:|:||||||.:::.|:::..|..|||:||..|.|.:..:.:|..:|.||||.|.
 Worm   427 -RVQPCKPNMLRFYMEQHVERLLQQYKEREKRMKQLEKEMVSAQLPDIMRNKMLGLLQQKESKYT 490

Human   659 RLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILA 723
            ||:|.||.||.|..|..:|:||||:|.|..|.||..:||||:|.|.||:.:.|.|||||||||||
 Worm   491 RLRRQKMSKSHFTVISHIGVGAFGKVSLVRKNDTRKVYAMKSLEKADVIMKQQAAHVKAERDILA 555

Human   724 EADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMG 788
            |||:.|:|:|::||||...|||:|:|:||||||:|||:..:|.|.|||||||||..|||.||.:|
 Worm   556 EADSPWIVRLFFSFQDDACLYFIMEYVPGGDMMTLLIQKGIFEEDLARFYIAELACAIEYVHNVG 620

Human   789 FIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYY-QKGSHVRQD--SMEPSDLWDDVSNC 850
            |||||:||||||||..|||||||||||||.||||:.:|| .:..|.|.|  |:.|.....|.|
 Worm   621 FIHRDLKPDNILIDQHGHIKLTDFGLCTGLRWTHDRRYYGPENDHHRVDSFSLPPEVAAIDKS-- 683

Human   851 RCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPF 915
                 :|.|  ..|:|.:|..|||||||.||:||||:.:.|:.|.|||||.||||:||:.|:.||
 Worm   684 -----VKVL--NVRQQTRRITAHSLVGTGNYMAPEVIAKTGHNQSCDWWSTGVILYEMVFGRVPF 741

Human   916 LAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGAD------DLKAHPF 974
            ...||..||.::.||.|.|.......||.|...:|.:|.|.|..|||.:|.|      .:|.||:
 Worm   742 HDDTPGGTQHRIKNWRNFLDFTYCGNLSKECLMMIQQLICDASSRLGSHGKDVAERTAQVKNHPW 806

Human   975 FSAIDFSSDIRKQPAP--YVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNK---H 1034
            |..||: .::||..|.  |:|.::|..|||||:...:    ||.::          .||.:   :
 Worm   807 FRGIDW-VNLRKLRADYIYIPRVTHDEDTSNFETFQD----NDRAD----------KPNVRGLHN 856

Human  1035 PEHAFYEFTFRRFFDDNGYPFRCP--KPS 1061
            |  ||||||:|.|||.:.  ..||  :||
 Worm   857 P--AFYEFTYRHFFDTDS--VGCPSLRPS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LATS2	XP_054230417.1	UBA_LATS2	101..141	CDD:270581	4/43 (9%)
		PHA03247	<143..521	CDD:223021	72/418 (17%)
		MobB_LATS2	587..669	CDD:439272	32/81 (40%)
		STKc_LATS2	668..1048	CDD:173715	196/393 (50%)
wts-1	NP_492699.1	MobB_LATS	437..497	CDD:439269	26/59 (44%)
		STKc_LATS	500..868	CDD:270749	196/393 (50%)