DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW and frpr-16

DIOPT Version :9

Sequence 1:	NP_000504.1	Gene:	OPN1MW / 2652	HGNCID:	4206	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_495204.1	Gene:	frpr-16 / 187838	WormBaseID:	WBGene00020023	Length:	340	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	75/381 - (19%)
Similarity:	141/381 - (37%)	Gaps:	122/381 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    50 RWVYHLTSVWM----IFVVIASVFTNGLVL-AATMKFKKLRHPLNWILVNLAVADLAETVIASTI 109
            |:.::....||    ||:.:...|.:.||. .|.|:    :..:..:|:.|::.|:...::.:.|
Worm     3 RYEFYELKSWMYLPVIFIGLLGNFASFLVYRTAPMR----KSTVGTLLLILSLIDILLLILITPI 63

Human   110 SVVN---------QVYGYFV--------LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCK 157
            .|:.         |.|.:.:        ..:|:|::    ...|   .|:.:.:|:.|||:.||:
Worm    64 FVLVFLPLWQDQWQKYSFHMSFFAYSTRYVYPLCMM----TKSC---SLYLMVLITIERWIAVCR 121

Human   158 PFGNVRFDAKLAI-------VGIAFSWIWAAVWTAPPIFGW-------SRYWPHGLKTSCGPDVF 208
            |     ..||:..       .|| |..|::.|:..|..|.:       |..|....:......:|
Worm   122 P-----LQAKVLCTNRNTMKAGI-FIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMF 180

Human   209 SGSSYPGVQSYMIVLMVTC-CITPLSIIVLCYLQVWLAIRAVAKQQKESEST-----QKAEKEVT 267
                      |.|:|.|.. ...|..|:.:....|   |||:  |:.:...|     ::.:::.|
Worm   181 ----------YFIILSVIFDYFLPFLIMTIANYHV---IRAL--QESDEVITGLAVQKRKDQKTT 230

Human   268 RMVVVMVLAFCFC------------------------WGPYAFFACFAAANPGYPFHPLMAALPA 308
            .|::|:.:.|.||                        |..:|.|..|.                .
Worm   231 VMLLVVTIFFAFCHLFSMFLKVAESIFGGFLTQTSFYWEVFAEFTIFL----------------I 279

Human   309 FFAKSATIYNPVIYVFMNRQFRNCILQLF--GKKVDDGSELSSASKTEVSSVSSVS 362
            .|..|:|.:   ||...:.:||.....:.  .:::||   :..::...|:|..:||
Worm   280 IFHTSSTFF---IYYGFSEKFRTIFHDIIRCRQRLDD---VKCSTYLPVNSSGAVS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW	NP_000504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269\|PubMed:30948514	17..43
		7tm_4	61..>178	CDD:304433	30/141 (21%)
		7tm_1	71..322	CDD:278431	59/312 (19%)
frpr-16	NP_495204.1	7tmA_FMRFamide_R-like	13..301	CDD:320109	67/338 (20%)
		TM helix 1	13..34	CDD:320109	6/20 (30%)
		TM helix 2	48..70	CDD:320109	4/21 (19%)
		TM helix 3	91..113	CDD:320109	5/28 (18%)
		TM helix 4	136..152	CDD:320109	5/16 (31%)
		TM helix 5	180..203	CDD:320109	7/32 (22%)
		TM helix 6	227..252	CDD:320109	6/24 (25%)
		TM helix 7	269..294	CDD:320109	8/43 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910