DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW and frpr-11

DIOPT Version :9

Sequence 1:	NP_000504.1	Gene:	OPN1MW / 2652	HGNCID:	4206	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001343679.1	Gene:	frpr-11 / 187065	WormBaseID:	WBGene00019444	Length:	370	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	69/352 - (19%)
Similarity:	140/352 - (39%)	Gaps:	66/352 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    53 YHLTSVW---MIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIA-------- 106
            |.:..|:   |:.:::..:|.|.:.:....:....::.:.::|::|:..||...:.|
Worm    31 YDMVEVFAMIMLPLILIGIFGNIISIYVYSRHHMNKNTIGFLLLSLSTIDLIVLITAMPSFGTYK 95

Human   107 -------STISVVNQVYGYFVLGHPMCVLEGYTVSLCG-ITGLWSLAIISWERWMVVCKPF---- 159
                   ..|..|:.::..|      |::..|.:...| :.|.:.:.:||.|||..||:|.
Worm    96 FPFFPGYHEIGSVHTIFSAF------CLIYFYPLMCMGKMMGQYIIVLISVERWFAVCRPLQVQI 154

Human   160 -----GNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSY 219
                 ..:|  |...|:.|:.      ::.||..|.:......|: ...|....|.:.:.....|
Worm   155 WCTQKNTIR--AMTCIIAISI------LFNAPRFFEFKANLITGV-IGFGLAHISKNEWYFYLYY 210

Human   220 MIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPY 284
            .|..::...:.|.|||.:..:||...:|...:::|...:.|:.:.:.|.|::||:..:..|
Worm   211 GIRAIIFDALIPFSIIAVTNIQVIQQLRKSNEERKLMTTQQQKDNKTTTMLLVMIFMYAIC---- 271

Human   285 AFFAC--------FAAANPGYPF------HPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQ 335
             .|.|        |:.....:.|      |.:...|..|::.| |.:   ||:..:.::||.:..
Worm   272 -HFLCTSVKFINLFSHNYVQFQFVIFKIIHHISNVLLVFYSAS-TFF---IYLIFSEKYRNVLST 331

Human   336 LFGKKVDDGSELSSASKTEVSSVSSVS 362
            ....:..|...:||..:....:..|.|
Worm   332 CVTCRNTDELTVSSRGRQNTKTTRSNS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW	NP_000504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269\|PubMed:30948514	17..43
		7tm_4	61..>178	CDD:304433	26/141 (18%)
		7tm_1	71..322	CDD:278431	56/289 (19%)
frpr-11	NP_001343679.1	7tmA_FMRFamide_R-like	36..329	CDD:320109	63/316 (20%)
		TM helix 1	37..61	CDD:320109	3/23 (13%)
		TM helix 2	70..92	CDD:320109	5/21 (24%)
		TM helix 3	118..140	CDD:320109	4/21 (19%)
		TM helix 4	163..179	CDD:320109	5/23 (22%)
		TM helix 5	208..231	CDD:320109	6/22 (27%)
		TM helix 6	255..280	CDD:320109	7/29 (24%)
		TM helix 7	297..322	CDD:320109	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910