DRSC/TRiP Functional Genomics Resources

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Protein Alignment OPN1MW and npr-35

DIOPT Version :9

Sequence 1:NP_000504.1 Gene:OPN1MW / 2652 HGNCID:4206 Length:364 Species:Homo sapiens
Sequence 2:NP_001023088.1 Gene:npr-35 / 183681 WormBaseID:WBGene00016842 Length:381 Species:Caenorhabditis elegans


Alignment Length:301 Identity:63/301 - (20%)
Similarity:130/301 - (43%) Gaps:32/301 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    50 RWVYHLTSVWMI---FVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISV 111
            |..|.||.::.:   .|....|..|..|:.|....|.|....::::::||:|||....|....::
 Worm    23 RHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLPTTL 87

Human   112 VNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFG-NVRFDAKLAIVGIAF 175
            :|.::..::.|...|.|..:..:......:::|..::.:|::.:|.... |..:|.:..      
 Worm    88 INSIFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYT------ 146

Human   176 SWIWAAVWTAPPIFG---WSRY----WPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLS 233
            .::..|||....|||   |..|    |..|   |.|..:.:..:...:. ::.|.::...|.|..
 Worm   147 KYVIFAVWLVAAIFGIPNWYNYDLIVWQEG---SYGYRLCTSQTDQKLY-FLFVNLLLAFIVPFG 207

Human   234 IIVLCYLQVWLAI---RAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGP----YAFFACFA 291
            :|...|.::::.:   |::|...:..|  .:.:..|..|::.:::.|..||.|    :.:|..||
 Worm   208 LISGLYTRIFITVSTHRSLAVDARARE--DRVKLRVATMMLTVIIVFACCWLPLYCIFTYFFFFA 270

Human   292 AANPGYPFHPLMAALPAF--FAKSATIYNPVIYVFMNRQFR 330
            ...........|...|.|  .:..::..||:||:..:.::|
 Worm   271 DQRSDLFQITSMLIRPIFQWMSLLSSSLNPIIYIAYSHKYR 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPN1MWNP_000504.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for 11-cis-retinal regeneration. /evidence=ECO:0000269|PubMed:30948514 17..43
7tm_4 61..>178 CDD:304433 22/120 (18%)
7tm_1 71..322 CDD:278431 54/267 (20%)
npr-35NP_001023088.1 7tm_GPCRs 30..314 CDD:391938 59/294 (20%)
TM helix 1 31..57 CDD:341315 5/25 (20%)
TM helix 2 64..90 CDD:341315 6/25 (24%)
TM helix 3 102..132 CDD:341315 4/29 (14%)
TM helix 4 146..164 CDD:341315 6/23 (26%)
TM helix 5 190..215 CDD:341315 5/25 (20%)
TM helix 6 236..267 CDD:341315 6/30 (20%)
TM helix 7 282..307 CDD:341315 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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