DRSC/TRiP Functional Genomics Resources

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Protein Alignment OPN1MW and dop-6

DIOPT Version :9

Sequence 1:NP_000504.1 Gene:OPN1MW / 2652 HGNCID:4206 Length:364 Species:Homo sapiens
Sequence 2:NP_001359889.1 Gene:dop-6 / 180706 WormBaseID:WBGene00016037 Length:692 Species:Caenorhabditis elegans


Alignment Length:210 Identity:50/210 - (23%)
Similarity:93/210 - (44%) Gaps:27/210 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    47 IAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISV 111
            :.|.|.|.:.|:    |.:..:..|.:|:||....|.|:.|.|.:||:||:|||.........|:
 Worm    20 LQPEWAYLVLSI----VPLVCILGNLMVVAAVWTTKSLQTPTNHLLVSLAMADLIVGAFVMPFSI 80

Human   112 ---VNQVYGYFVLGHPMCVLEGYTV--SLCGITGLWSLAIISWERWMVVCKP--FGNVRFDAKLA 169
               ||:::.:.    |:.|...|.|  .....:.:..|.:||.:|.:...||  :..|: ..|..
 Worm    81 YLSVNRLHWHL----PLFVCYFYCVLDVAASTSSIIHLVLISIDRLVAATKPAEYKTVK-HRKRV 140

Human   170 IVGIAFSWIWAAVWTAPPIFGWSRYWPHGL--KTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPL 232
            .:.||.:||::...:.|...|::....:.|  :..||  :::       ..||:...:.....|.
 Worm   141 YLAIAITWIFSIALSLPLGTGFNTRTSYFLVIEHHCG--IYN-------PIYMLGSSIFAFYLPC 196

Human   233 SIIVLCYLQVWLAIR 247
            .|::..|..::..:|
 Worm   197 LIMIFTYGYIFYTLR 211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPN1MWNP_000504.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for 11-cis-retinal regeneration. /evidence=ECO:0000269|PubMed:30948514 17..43
7tm_4 61..>178 CDD:304433 33/123 (27%)
7tm_1 71..322 CDD:278431 45/186 (24%)
dop-6NP_001359889.1 7tmA_amine_R-like 24..>217 CDD:320098 49/206 (24%)
TM helix 1 25..49 CDD:320098 7/27 (26%)
TM helix 2 58..80 CDD:320098 8/21 (38%)
TM helix 3 97..119 CDD:320098 4/21 (19%)
TM helix 4 142..158 CDD:320098 4/15 (27%)
TM helix 5 181..204 CDD:320098 4/22 (18%)
7tm_GPCRs <464..542 CDD:391938
TM helix 6 466..496 CDD:341315
TM helix 7 513..535 CDD:341315
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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