Protein Alignment OPN1MW and dop-2

DIOPT Version :9

• Sequence 1: NP_000504.1
• Gene: OPN1MW / 2652
• HGNCID: 4206
• Length: 364
• Species: Homo sapiens
• Sequence 2: NP_001256126.1
• Gene: dop-2 / 179347
• WormBaseID: WBGene00001053
• Length: 849
• Species: Caenorhabditis elegans
• Alignment Length: 265
• Identity: 58/265 - (21%)
• Similarity: 117/265 - (44%)
• Gaps: 46/265 - (17%)

Human    60 MIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVY---GYFVL 121
            :|.:.:.::..|.||:.:.::::.|:..:|::::.||||||...:|....:|  .||   |.:.|
 Worm    44 LIVIPLITLLGNLLVIISVLRYRALQSAINFLILGLAVADLLVAIIVMPYAV--YVYVTNGDWYL 106

Human   122 GHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKP--FGNVRFDAKLAIVGIAFSWIWAAVWT 184
            |:.||.:...:...|....:..||:||::|:..|..|  :.....:.|.....||..|:.:....
 Worm   107 GNLMCDIYMASDVCCSTASILLLAVISFDRYRAVSLPIQYSRQSQNVKRVWTLIAVIWLVSLTLA 171

Human   185 APPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIR-- 247
            :|.:||.:...|......|.   |..:.: .:.|.||..::.|     .:::..|:::.:|::
 Worm   172 SPMVFGVNVRPPDANPYECR---FYNAEF-SILSSMISFVIPC-----FLVLFVYIRIIIALKKR 227

Human   248 -AVAKQQKESES--------TQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLM 303
             ..||.::|..:        ....|::|.......::|     ||..              :.:|
 Worm   228 EKAAKMRREKNTIAHGLTMRPDTGEEQVDEEAAGRIVA-----GPVV--------------NVMM 273

Human   304 AALPA 308
            ||||:
 Worm   274 AALPS 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW	NP_000504.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269|PubMed:30948514	17..43
		7tm_4	61..>178	CDD:304433	32/121 (26%)
		7tm_1	71..322	CDD:278431	57/254 (22%)
dop-2	NP_001256126.1	7tmA_D2-like_dopamine_R	38..>233	CDD:320181	46/199 (23%)
		TM helix 1	40..64	CDD:320181	4/19 (21%)
		TM helix 2	73..95	CDD:320181	8/21 (38%)
		TM helix 3	112..134	CDD:320181	4/21 (19%)
		TM helix 4	158..174	CDD:320181	3/15 (20%)
		TM helix 5	195..218	CDD:320181	4/28 (14%)
		7tm_GPCRs	<745..828	CDD:421689
		TM helix 6	751..781	CDD:410628
		TM helix 7	796..821	CDD:410628

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910