DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HEYL and E(spl)m3-HLH

DIOPT Version :9

Sequence 1:	NP_055386.2	Gene:	HEYL / 26508	HGNCID:	4882	Length:	328	Species:	Homo sapiens
Sequence 2:	NP_524509.2	Gene:	E(spl)m3-HLH / 43156	FlyBaseID:	FBgn0002609	Length:	224	Species:	Drosophila melanogaster

Alignment Length:	166	Identity:	42/166 - (25%)
Similarity:	78/166 - (46%)	Gaps:	35/166 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    38 SSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEVLQMTVDHLKMLHA 100
            |...|.||..:.::|::||.|||..|.:|:.|:....:::|.  ::||||::|::||||::.|..
  Fly     6 SKTYQYRKVMKPLLERKRRARINKCLDDLKDLMVECLQQEGEHVTRLEKADILELTVDHMRKLKQ 70

Human   101 TGGTGF------------FDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHL 153
            .||...            ..:.|....||| |:.....::.:.|  |:  :.:.|.:..:::..|
  Fly    71 RGGLSLQGVVAGVGSPPTSTSTAHVESFRS-GYVHAADQITQVL--LQ--TQQTDEIGRKIMKFL 130

Human   154 NSYAAEMEPS----------------PTPTGPLAFP 173
            ::...|::..                |..:|.||||
  Fly   131 STRLIELQTQLLQQQQQQQQHQQQQIPQSSGRLAFP 166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57		6/18 (33%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		25/82 (30%)
		HLH	42..100	CDD:238036	23/59 (39%)
		ORANGE	115..162	CDD:128787	9/46 (20%)
		Atrophin-1	<136..311	CDD:331285	9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..308
E(spl)m3-HLH	NP_524509.2	HLH	11..70	CDD:238036	22/58 (38%)
E(spl)m3-HLH	NP_524509.2	ORANGE	96..136	CDD:128787	8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740