Protein Alignment CNNM4 and MAM3

DIOPT Version :9

• Sequence 1: XP_005263971.1
• Gene: CNNM4 / 26504
• HGNCID: 105
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_014581.1
• Gene: MAM3 / 854094
• SGDID: S000005421
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 680
• Identity: 189/680 - (27%)
• Similarity: 318/680 - (46%)
• Gaps: 135/680 - (19%)

Human   185 HILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKI-EPIRRKGNYLLCSLLL 248
            :.::..:|::|.|:|:||.||||..|.:.|:::...|:..|::.|::: :.|.|..:::|.:|||
Yeast    64 YYIISIILVLLGGVFAGLTLGLMGQDEVYLKVISTSGSNSEKKLAKRVLDLISRGKHWVLVTLLL 128

Human   249 GNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLT 313
            .||:.|.:|.|:||..:|.|..||.||||.|||||||:||::|.::||.|||.........|.|.
Yeast   129 SNVITNETLPIVLDRCLGGGWQAVVSSTILIVIFGEIIPQSVCVKYGLQVGAFFCPFVLVLMYLM 193

Human   314 FPLSFPISKLLDFFLGQEIRTVYNRE--KLMEMLKVTEPYNDLVKEELNMIQGALELRTKTVEDI 376
            :|:::||:.|||:.||::..|:|.:.  |.:..|..|.....|.|:|:.:|...|:|:.|.||:|
Yeast   194 YPVAYPIATLLDYMLGEDHGTMYKKSGLKTLVTLHRTMGVERLTKDEVTIISAVLDLKAKRVEEI 258

Human   377 MTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVF-EDEQSNIVDILYVKDLAFVDPDDCTPLKT 440
            ||.:::.|.:.:|.|||..|:.:|..||::|||:| .:|.:|.:.:|.|:.|...|||||.|:.
Yeast   259 MTPIENVFTMSADTILDDKTVEKIFNSGFSRIPIFLPNEPNNFIGMLLVRVLISYDPDDCLPIS- 322

Human   441 ITRFYNHPVHF-------VFHDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLED 498
                     ||       ...:|....:|..|::||:|:.:|.|......|     .:|::||||
Yeast   323 ---------HFPLATLPETSPNTSCLNILNYFQEGKAHMCVVSKEPGSSHG-----AIGVLTLED 373

Human   499 VIEEIIKSEILDESDMYTDNRS---RKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR--FL 558
            ||||:|..||:||||::.|...   |::....:||..:::..           .|..::|:  ..
Yeast   374 VIEELIGEEIVDESDVFVDMHQHIMRQQPGPLSKRHITSYLH-----------HLYTSSHKEHKA 427

Human   559 ATEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVE 623
            |.:..:.|| |:|........::|.  |:|    :||.:.:    ..|...|....:|....:|
Yeast   428 ADQADESSP-LLSPSNSNHPSEHPQ--QDL----NNKSWKQ----KSNDGYDRSNAVLSPTPQV- 480

Human   624 AGKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPPGKRNSLLCWLTDRSPAH------------ 676
                         :.:||:       :||.....|.....|   ::|.:.||:
Yeast   481 -------------TEHGTI-------IPSNLASNPLNVNKS---FVTIKKPANVPKIITTHTPHS 522

Human   677 -----PTPLSRSASLS------YPDRTDVSTAATL----AGSSNQFGSSVLGQYISDFSV----- 721
                 |.|.|...|||      ..|..::|..|.|    :|...|..:|......|..|:
Yeast   523 SKEPSPAPHSNDKSLSAEEQQLLSDHAELSRQAVLHTQRSGQPTQVTTSTKTTRNSPDSISIPNS 587

Human   722 ---------RALVDLQYIKITRQQYQNGLLAS--RMENSPQFPIDGCTTHMENLAEKSELPVVDE 775
                     ...:...|     |..:||::.|  .::..|:..|.......|:.:|.....:..|
Yeast   588 GANHGNENQNVTISTSY-----QNTKNGIVESVITVKGVPKTIIGPAKDWDESKSEYGNENINQE 647

Human   776 TTTLLNER----------NSLLHKASHENA 795
            .:...::|          :|:.:|..:|||
Yeast   648 NSNRSDDRESSSSNASLFSSIKNKFKNENA 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_005263971.1	DUF21	196..358	CDD:279876	66/164 (40%)
		CBS	373..500	CDD:223591	45/134 (34%)
		CBS_pair_CorC_HlyC_assoc	382..502	CDD:239963	42/127 (33%)
MAM3	NP_014581.1	TlyC	35..>396	CDD:224173	130/346 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I1288
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm52724
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1902
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700