DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNNM4 and uex

DIOPT Version :9

Sequence 1:	XP_005263971.1	Gene:	CNNM4 / 26504	HGNCID:	105	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_001104390.2	Gene:	uex / 5740320	FlyBaseID:	FBgn0262124	Length:	834	Species:	Drosophila melanogaster

Alignment Length:	756	Identity:	329/756 - (43%)
Similarity:	451/756 - (59%)	Gaps:	77/756 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    46 IVGMRLASCNKSCGTNPDGIIFVSEGSTVNLRLYGYSLGNISSNLISFTEVDDAETLHKSTSCLE 110
            |||:||.  :::..|. :||..|........|::|..|.  .:..|:||.    |.......||:
  Fly    58 IVGIRLE--DETVETK-NGIPTVLVDKEQQFRVFGSGLE--ENTAITFTN----EKNDYGGPCLK 113

Human   111 LTKDLVVQQLVNVSRGNTSGVLVV-----LTKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLL 170
            ...||...  :.||....|.:..|     :.:|...:::.:.....::|....|.....:.|.|.
  Fly   114 PATDLFTP--IEVSSNGFSALYSVKFPSFINEFFICAKTAEKTTNHSKAATTTPLEHQGNSDFLK 176

Human   171 FMVEEPGRFLPLWLHILLITVLLVLSGIFSGLNLGLMALDPMELRIVQNCGTEKERRYARKIEPI 235
            ....||  .:|:||.|::|...|..|.:|||||||||::|..||:|::|.|||||::||.||.|:
  Fly   177 IKTFEP--LIPVWLAIIIIVTCLGFSALFSGLNLGLMSMDRTELKILRNTGTEKEKKYASKIAPV 239

Human   236 RRKGNYLLCSLLLGNVLVNTSLTILLDNLIGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGA 300
            |.:|||||||:||||||||::.|||||.|. |||.||..||:.||:||||.|||:|||||||:||
  Fly   240 RDQGNYLLCSILLGNVLVNSTFTILLDGLT-SGLFAVIFSTLAIVLFGEITPQAVCSRHGLAIGA 303

Human   301 NTILLTKFFMLLTFPLSFPISKLLDFFLGQEIRTVYNREKLMEMLKVTEPYNDLVKEELNMIQGA 365
            .|||:||..|.:|.|||:|:|::||..||:||..|||||:|.|:::||...|||.|.|:|:|.||
  Fly   304 KTILVTKTVMAITAPLSYPVSRILDKLLGEEIGNVYNRERLKELVRVTNDVNDLDKNEVNIISGA 368

Human   366 LELRTKTVEDIMTQLQDCFMIRSDAILDFNTMSEIMESGYTRIPVFEDEQSNIVDILYVKDLAFV 430
            ||||.|||.|:||.:.|.||:..||:|||.|:||||.|||:||||::.::.|||.:||:||||||
  Fly   369 LELRKKTVADVMTHINDAFMLSLDALLDFETVSEIMNSGYSRIPVYDGDRKNIVTLLYIKDLAFV 433

Human   431 DPDDCTPLKTITRFYNHPVHFVFHDTKLDAMLEEFKKGK-SHLAIVQKVNNEGEGDPFYEVLGLV 494
            |.||.|||||:..||.:||||||.|..||.|..:||:|. .|:|.|.:|||||:||||||.:|||
  Fly   434 DTDDNTPLKTLCEFYQNPVHFVFEDYTLDIMFNQFKEGTIGHIAFVHRVNNEGDGDPFYETVGLV 498

Human   495 TLEDVIEEIIKSEILDESDMYTDNRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHRFLA 559
            ||||||||:|::||:||:|::.|||::.|.:...|.|||||.:......|:|||||.||..::|:
  Fly   499 TLEDVIEELIQAEIVDETDVFVDNRTKTRRNRYKKADFSAFAERREVQTVRISPQLTLATFQYLS 563

Human   560 TEVSQFSPSLISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKPADYFILILQGKVEVEA 624
            |.|..|...:|||.||.|||. .||...:|....:|.....|::|:.|..|:|:|||:|:|||..
  Fly   564 TAVDAFKKDVISELILRRLLN-QDVFHNIKTKGKSKDDPSLYIFTQGKAVDFFVLILEGRVEVTI 627

Human   625 GKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPPGKRNSLLCWLTDRSPAHPTPLSRSASLSYP 689
            |||.:.||:|.|:|:||.||     ||:|.:..|
  Fly   628 GKEALMFESGPFTYFGTQAL-----VPNVVIDSP------------------------------- 656

Human   690 DRTDVSTAATLAGS--SNQFGSSVLGQYISDFSVRALVDLQYIKITRQQYQNGLLASRMENSPQ- 751
                     |..||  |....|.:...::.|:||||:.|:.||.|.|..|.....|:.:|.|.:
  Fly   657 ---------TQMGSLQSLNMDSKIRQSFVPDYSVRAISDVIYITIKRVLYLTAKKATLLEKSRKS 712

Human   752 --FPIDGCTTHMENLA------EKSELPVVDETTTLLNERN 784
              |..:.....:|.|.      ||......:::|..|:.|:
  Fly   713 GTFSSETFDDEVERLLHSITENEKPSCFAQNQSTRRLSNRS 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_005263971.1	DUF21	196..358	CDD:279876	103/161 (64%)
		CBS	373..500	CDD:223591	79/127 (62%)
		CBS_pair_CorC_HlyC_assoc	382..502	CDD:239963	77/120 (64%)
uex	NP_001104390.2	DUF21	188..361	CDD:279876	107/173 (62%)
		CBS_pair_CorC_HlyC_assoc	384..506	CDD:239963	77/121 (64%)
		CAP_ED	<604..>650	CDD:294041	25/50 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155084
Domainoid	1	1.000	218	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I1067
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1446644at2759
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm40918
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	1	1.100	-	-	LDO	PTHR12064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760