Protein Alignment CNNM4 and mam301

DIOPT Version :10

• Sequence 1: XP_047299867.1
• Gene: CNNM4 / 26504
• HGNCID: 105
• Length: 797
• Species: Homo sapiens
• Sequence 2: NP_588087.1
• Gene: mam301 / 2538837
• PomBaseID: SPCC4B3.03C
• Length: 679
• Species: Schizosaccharomyces pombe
• Alignment Length: 605
• Identity: 177/605 - (29%)
• Similarity: 288/605 - (47%)
• Gaps: 101/605 - (16%)

Human   136 TKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFS 200
            |.|:........|.|....|.||..:.........|:..|.......|:.:::..||::|.|:|:
pombe    16 TVFILLQSYAVAYPLRAFRQNDGIGIAMNPSQDGGFVSAEKDSDFEYWMKLIISAVLILLGGVFA 80

Human   201 GLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKG-NYLLCSLLLGNVLVNTSLTILLDNL 264
            ||.:|||..|.:.|::::..|...||.:|||:..:.|:| :::|.:||||||:||.:|.|:.|::
pombe    81 GLTIGLMGCDDLHLQVLEQSGDASERVHARKVLKLLRRGKHWVLVTLLLGNVIVNETLPIVFDSI 145

Human   265 IGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLG 329
            ||.|..||..||..||||||::|||.|.|:||::||....:..|.|.|.:|:::|.:.:||..||
pombe   146 IGGGWPAVLISTAMIVIFGEVIPQATCVRYGLSIGAKLEPIVLFMMYLLWPIAYPTALILDACLG 210

Human   330 QEIRTVYNREKLMEMLKVTEPYNDLVKEELN-----MIQGALELRTKTVEDIMTQLQDCFMIRSD 389
            :...|:|.:..|..::.:   :.||..::||     :|...|:||.|..|.|||.::|.|.:..|
pombe   211 ESQSTMYKKSGLKTLVTL---HRDLGIDKLNQDEVTIITAVLDLREKHAESIMTPIEDVFTLPMD 272

Human   390 AILDFNTMSEIMESGYTRIPVFEDE-QSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVF 453
            .|||.:.:.||:.:||:||||.:.. ..:.:.:|..|.|...||||..|   :.:|....:...:
pombe   273 RILDEDLIGEIICAGYSRIPVHKPGFPHDFIGMLLTKTLIGYDPDDKWP---VGKFALATLPQTW 334

Human   454 HDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTD- 517
            .:|....:|...::||||:.::    :...|:| :..:|::||||:|||:|..||:||:|:|.|
pombe   335 PNTSCLDLLNYCQEGKSHMILI----SNSPGEP-HGAIGVITLEDIIEELIGEEIIDETDVYIDV 394

Human   518 NRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR--------------FLATEVSQFSPS 568
            ::...||.|.|        |..|.:..:.....:.|.|:              .|..:.|..:|.
pombe   395 HKGLPRVGENN--------DFWNRMLHRSHLSTMAALHKSQRSHDLAANEHAPILNPKNSALNPR 451

Human   569 LISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKP--ADYFILILQGKVEVEA------- 624
            |::...:  .:|.|.:||.          :..|......|  :|....|.:...|::|
pombe   452 LVTNDRV--KVKSPSLIQS----------STGYGSMSQSPSRSDLPSKISRVNAELQAHGSQRSS 504

Human   625 ---GKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPPGKRNSLLCWLTDRSPAHPTPLSRSASL 686
               .|||.               :||...||                    |.||..| |.....
pombe   505 IDVSKENK---------------SSVADGPS--------------------SQAHNGP-STQPPE 533

Human   687 SYPDRTDVSTAATLAGSSNQ 706
            :.|:.||.|::.|...:.||
pombe   534 ALPNGTDPSSSKTTENNGNQ 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_047299867.1	TlyC	196..>513	CDD:440865	120/323 (37%)
mam301	NP_588087.1	TlyC	63..>373	CDD:440865	113/320 (35%)