DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CNNM4 and SPCC4B3.03c

DIOPT Version :9

Sequence 1:	XP_005263971.1	Gene:	CNNM4 / 26504	HGNCID:	105	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_588087.1	Gene:	SPCC4B3.03c / 2538837	PomBaseID:	SPCC4B3.03c	Length:	679	Species:	Schizosaccharomyces pombe

Alignment Length:	605	Identity:	177/605 - (29%)
Similarity:	288/605 - (47%)	Gaps:	101/605 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   136 TKFLRRSESMKLYALCTRAQPDGPWLKWTDKDSLLFMVEEPGRFLPLWLHILLITVLLVLSGIFS 200
            |.|:........|.|....|.||..:.........|:..|.......|:.:::..||::|.|:|:
pombe    16 TVFILLQSYAVAYPLRAFRQNDGIGIAMNPSQDGGFVSAEKDSDFEYWMKLIISAVLILLGGVFA 80

Human   201 GLNLGLMALDPMELRIVQNCGTEKERRYARKIEPIRRKG-NYLLCSLLLGNVLVNTSLTILLDNL 264
            ||.:|||..|.:.|::::..|...||.:|||:..:.|:| :::|.:||||||:||.:|.|:.|::
pombe    81 GLTIGLMGCDDLHLQVLEQSGDASERVHARKVLKLLRRGKHWVLVTLLLGNVIVNETLPIVFDSI 145

Human   265 IGSGLMAVASSTIGIVIFGEILPQALCSRHGLAVGANTILLTKFFMLLTFPLSFPISKLLDFFLG 329
            ||.|..||..||..||||||::|||.|.|:||::||....:..|.|.|.:|:::|.:.:||..||
pombe   146 IGGGWPAVLISTAMIVIFGEVIPQATCVRYGLSIGAKLEPIVLFMMYLLWPIAYPTALILDACLG 210

Human   330 QEIRTVYNREKLMEMLKVTEPYNDLVKEELN-----MIQGALELRTKTVEDIMTQLQDCFMIRSD 389
            :...|:|.:..|..::.:   :.||..::||     :|...|:||.|..|.|||.::|.|.:..|
pombe   211 ESQSTMYKKSGLKTLVTL---HRDLGIDKLNQDEVTIITAVLDLREKHAESIMTPIEDVFTLPMD 272

Human   390 AILDFNTMSEIMESGYTRIPVFEDE-QSNIVDILYVKDLAFVDPDDCTPLKTITRFYNHPVHFVF 453
            .|||.:.:.||:.:||:||||.:.. ..:.:.:|..|.|...||||..|   :.:|....:...:
pombe   273 RILDEDLIGEIICAGYSRIPVHKPGFPHDFIGMLLTKTLIGYDPDDKWP---VGKFALATLPQTW 334

Human   454 HDTKLDAMLEEFKKGKSHLAIVQKVNNEGEGDPFYEVLGLVTLEDVIEEIIKSEILDESDMYTD- 517
            .:|....:|...::||||:.::    :...|:| :..:|::||||:|||:|..||:||:|:|.|
pombe   335 PNTSCLDLLNYCQEGKSHMILI----SNSPGEP-HGAIGVITLEDIIEELIGEEIIDETDVYIDV 394

Human   518 NRSRKRVSEKNKRDFSAFKDADNELKVKISPQLLLAAHR--------------FLATEVSQFSPS 568
            ::...||.|.|        |..|.:..:.....:.|.|:              .|..:.|..:|.
pombe   395 HKGLPRVGENN--------DFWNRMLHRSHLSTMAALHKSQRSHDLAANEHAPILNPKNSALNPR 451

Human   569 LISEKILLRLLKYPDVIQELKFDEHNKYYARHYLYTRNKP--ADYFILILQGKVEVEA------- 624
            |::...:  .:|.|.:||.          :..|......|  :|....|.:...|::|
pombe   452 LVTNDRV--KVKSPSLIQS----------STGYGSMSQSPSRSDLPSKISRVNAELQAHGSQRSS 504

Human   625 ---GKENMKFETGAFSYYGTMALTSVPSVPSVQVGCPPGKRNSLLCWLTDRSPAHPTPLSRSASL 686
               .|||.               :||...||                    |.||..| |.....
pombe   505 IDVSKENK---------------SSVADGPS--------------------SQAHNGP-STQPPE 533

Human   687 SYPDRTDVSTAATLAGSSNQ 706
            :.|:.||.|::.|...:.||
pombe   534 ALPNGTDPSSSKTTENNGNQ 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNNM4	XP_005263971.1	DUF21	196..358	CDD:279876	65/162 (40%)
		CBS	373..500	CDD:223591	40/127 (31%)
		CBS_pair_CorC_HlyC_assoc	382..502	CDD:239963	37/120 (31%)
SPCC4B3.03c	NP_588087.1	DUF21	64..241	CDD:279876	70/179 (39%)
SPCC4B3.03c	NP_588087.1	CBS_pair	265..373	CDD:301603	33/115 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	134	1.000	Domainoid score	I1448
eggNOG	1	0.900	-	-		E1_COG1253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I1004
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000343
OrthoInspector	1	1.000	-	-		otm53402
orthoMCL	1	0.900	-	-		OOG6_100176
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1902
SonicParanoid	1	1.000	-	-		X235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790